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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 15 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CAB3
  • cytoplasm
    		•
  • response to salt stress
  • coenzyme A biosynthetic process
    		•
  • phosphopantothenoylcysteine decarboxylase activity
  • purine nucleotide binding
    		•
    CHD1
  • transcription elongation factor complex
  • SLIK (SAGA-like) complex
  • mitochondrion
  • SAGA complex
    		•
  • chromatin remodeling
  • RNA elongation from RNA polymerase II promoter
    		•
  • ATPase activity
  • RNA polymerase II transcription elongation factor activity
    		•
    CKA1
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 activity
    		•
    CKA2
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 activity
    		•
    CKB1
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 regulator activity
    		•
    CKB2
  • protein kinase CK2 complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
    		•
  • protein kinase CK2 regulator activity
    		•
    ELF1
  • nucleus
    		•
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    HOT1
  • nuclear chromosome
    		•
  • hyperosmotic response
  • regulation of transcription from RNA polymerase II promoter
    		•
  • specific RNA polymerase II transcription factor activity
    		•
    MSC3
  • cellular_component
    		•
  • reciprocal meiotic recombination
    		•
  • molecular_function
    		•
    NRG1
  • nucleus
    		•
  • pseudohyphal growth
  • response to pH
  • invasive growth in response to glucose limitation
  • glucose metabolic process
  • biofilm formation
  • regulation of transcription from RNA polymerase II promoter
    		•
  • DNA binding
  • transcription repressor activity
    		•
    PGA2
  • nuclear envelope
  • endoplasmic reticulum
    		•
  • secretory pathway
  • mitochondrion organization
    		•
  • molecular_function
    		•
    REH1
  • cytoplasm
    		•
  • biological_process
  • budding cell bud growth
    		•
  • molecular_function
    		•
    RIM13
  • cellular_component
    		•
  • protein processing
    		•
  • cysteine-type endopeptidase activity
    		•
    VHS3
  • cellular_component
    		•
  • G1/S transition of mitotic cell cycle
  • coenzyme A biosynthetic process
  • cellular monovalent inorganic cation homeostasis
    		•
  • phosphopantothenoylcysteine decarboxylase activity
  • phosphoprotein phosphatase inhibitor activity
    		•
    YLR407W
  • cellular_component
    		•
  • biological_process
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein kinase CK2 complex 2.0922E-11 15 4 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    regulation of transcription from RNA polymerase I promoter 2.0922E-11 15 4 4 6292
    regulation of transcription from RNA polymerase III promoter 7.292E-10 15 7 4 6292
    flocculation via cell wall protein-carbohydrate interaction 4.3568E-9 15 10 4 6292
    flocculation 6.8369E-9 15 11 4 6292
    G1/S transition of mitotic cell cycle 7.3044E-8 15 50 5 6292
    G2/M transition of mitotic cell cycle 4.7981E-7 15 29 4 6292
    transcription from RNA polymerase I promoter 5.5285E-7 15 30 4 6292
    transcription from RNA polymerase III promoter 1.4725E-6 15 38 4 6292
    interphase of mitotic cell cycle 2.0866E-6 15 97 5 6292
    interphase 2.0866E-6 15 97 5 6292
    cellular chemical homeostasis 5.7417E-6 15 119 5 6292
    cellular ion homeostasis 5.7417E-6 15 119 5 6292
    cellular homeostasis 5.9833E-6 15 120 5 6292
    transcription, DNA-dependent 6.1419E-6 15 503 8 6292
    RNA biosynthetic process 6.6162E-6 15 508 8 6292
    chemical homeostasis 6.7564E-6 15 123 5 6292
    ion homeostasis 6.7564E-6 15 123 5 6292
    transcription 1.2326E-5 15 552 8 6292
    multi-organism process 1.4134E-5 15 143 5 6292
    protein amino acid phosphorylation 8.0486E-5 15 103 4 6292
    regulation of transcription, DNA-dependent 1.05E-4 15 358 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0815E-4 15 1566 11 6292
    coenzyme A biosynthetic process 1.1065E-4 15 7 2 6292
    coenzyme A metabolic process 1.1065E-4 15 7 2 6292
    nucleoside bisphosphate metabolic process 1.1065E-4 15 7 2 6292
    regulation of RNA metabolic process 1.1345E-4 15 363 6 6292
    cell cycle phase 1.3801E-4 15 376 6 6292
    regulation of transcription 1.5512E-4 15 384 6 6292
    mitotic cell cycle 2.2599E-4 15 255 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.3821E-4 15 415 6 6292
    regulation of nitrogen compound metabolic process 2.4139E-4 15 416 6 6292
    regulation of gene expression 3.4924E-4 15 445 6 6292
    cellular nitrogen compound metabolic process 3.5742E-4 15 1770 11 6292
    regulation of macromolecule biosynthetic process 3.9896E-4 15 456 6 6292
    nitrogen compound metabolic process 4.0047E-4 15 1791 11 6292
    regulation of cellular biosynthetic process 4.8117E-4 15 472 6 6292
    regulation of biosynthetic process 4.8672E-4 15 473 6 6292
    purine ribonucleoside metabolic process 5.4716E-4 15 15 2 6292
    regulation of macromolecule metabolic process 5.7625E-4 15 488 6 6292
    cell cycle process 5.8912E-4 15 490 6 6292
    purine nucleoside metabolic process 6.2447E-4 15 16 2 6292
    response to stress 6.3592E-4 15 497 6 6292
    RNA metabolic process 6.452E-4 15 954 8 6292
    phosphorylation 6.7614E-4 15 179 4 6292
    cellular biosynthetic process 7.5786E-4 15 1567 10 6292
    regulation of primary metabolic process 7.6188E-4 15 514 6 6292
    cell cycle 8.5332E-4 15 525 6 6292
    ribonucleoside metabolic process 8.862E-4 15 19 2 6292
    gene expression 8.9699E-4 15 1283 9 6292
    biosynthetic process 9.1567E-4 15 1602 10 6292
    regulation of cellular metabolic process 9.5318E-4 15 536 6 6292
    response to stimulus 1.025E-3 15 766 7 6292
    regulation of metabolic process 1.062E-3 15 547 6 6292
    regulation of biological quality 1.1039E-3 15 551 6 6292
    group transfer coenzyme metabolic process 1.5419E-3 15 25 2 6292
    nucleoside metabolic process 1.6681E-3 15 26 2 6292
    phosphorus metabolic process 1.6996E-3 15 229 4 6292
    phosphate metabolic process 1.6996E-3 15 229 4 6292
    nucleic acid metabolic process 1.8909E-3 15 1415 9 6292
    response to DNA damage stimulus 1.8996E-3 15 236 4 6292
    homeostatic process 1.9507E-3 15 408 5 6292
    response to abiotic stimulus 2.422E-3 15 117 3 6292
    cellular macromolecule biosynthetic process 2.8537E-3 15 1187 8 6292
    macromolecule biosynthetic process 2.8858E-3 15 1189 8 6292
    RNA elongation from RNA polymerase II promoter 3.7359E-3 15 39 2 6292
    cellular response to stress 4.0293E-3 15 290 4 6292
    RNA elongation 4.9503E-3 15 45 2 6292
    transcription from RNA polymerase II promoter 6.7464E-3 15 335 4 6292
    regulation of cellular process 7.3152E-3 15 796 6 6292
    coenzyme biosynthetic process 7.324E-3 15 55 2 6292
    primary metabolic process 7.8419E-3 15 2896 12 6292
    post-translational protein modification 8.4401E-3 15 357 4 6292
    regulation of biological process 8.6743E-3 15 824 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein kinase CK2 activity 5.3053E-6 15 2 2 6292
    protein kinase CK2 regulator activity 5.3053E-6 15 2 2 6292
    phosphopantothenoylcysteine decarboxylase activity 1.5894E-5 15 3 2 6292
    obsolete_molecular_function 1.651E-5 15 69 4 6292
    RNA polymerase II transcription elongation factor activity 4.0759E-4 15 13 2 6292
    transcription elongation regulator activity 8.862E-4 15 19 2 6292
    carboxy-lyase activity 9.8331E-4 15 20 2 6292
    carbon-carbon lyase activity 2.2205E-3 15 30 2 6292
    transcription regulator activity 7.0355E-3 15 339 4 6292
    phosphoprotein phosphatase inhibitor activity 7.136E-3 15 3 1 6292
    phosphatase inhibitor activity 7.136E-3 15 3 1 6292
    cysteine-type endopeptidase activity 9.5041E-3 15 4 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle