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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 510.190.40
Complex Size: 5 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC36
  • nucleus
  • cytoplasm
  • CCR4-NOT core complex
  • negative regulation of transcription from RNA polymerase II promoter
  • response to pheromone involved in conjugation with cellular fusion
  • nuclear-transcribed mRNA poly(A) tail shortening
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • 3'-5'-exoribonuclease activity
  • CDC39
  • nucleus
  • cytoplasm
  • CCR4-NOT core complex
  • negative regulation of transcription from RNA polymerase II promoter
  • response to pheromone involved in conjugation with cellular fusion
  • pseudohyphal growth
  • nuclear-transcribed mRNA poly(A) tail shortening
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • 3'-5'-exoribonuclease activity
  • MOT2
  • cytoplasm
  • CCR4-NOT core complex
  • conjugation with cellular fusion
  • telomere maintenance
  • nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • 3'-5'-exoribonuclease activity
  • transcription repressor activity
  • NOT3
  • cytoplasm
  • CCR4-NOT core complex
  • nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of transcription from RNA polymerase II promoter
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • 3'-5'-exoribonuclease activity
  • NOT5
  • cytoplasm
  • CCR4-NOT core complex
  • nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • 3'-5'-exoribonuclease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    CCR4-NOT core complex 6.8252E-16 5 8 5 6292
    CCR4-NOT complex 2.44E-14 5 14 5 6292
    transcription factor complex 1.5869E-10 5 71 5 6292
    nucleoplasm part 8.6048E-8 5 245 5 6292
    nucleoplasm 1.2538E-7 5 264 5 6292
    nuclear lumen 1.895E-6 5 453 5 6292
    organelle lumen 1.2528E-5 5 660 5 6292
    intracellular organelle lumen 1.2528E-5 5 660 5 6292
    membrane-enclosed lumen 1.6827E-5 5 700 5 6292
    nuclear part 1.6432E-4 5 1103 5 6292
    protein complex 1.913E-4 5 1137 5 6292
    macromolecular complex 1.1794E-3 5 1635 5 6292
    nucleus 3.5796E-3 5 2041 5 6292
    organelle part 6.2578E-3 5 2282 5 6292
    intracellular organelle part 6.2578E-3 5 2282 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear-transcribed mRNA poly(A) tail shortening 6.8252E-16 5 8 5 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 9.8393E-13 5 27 5 6292
    mRNA 3'-end processing 2.0709E-12 5 31 5 6292
    nuclear-transcribed mRNA catabolic process 6.1176E-12 5 38 5 6292
    RNA 3'-end processing 1.0368E-11 5 42 5 6292
    mRNA catabolic process 1.3697E-10 5 69 5 6292
    RNA catabolic process 2.93E-10 5 80 5 6292
    RNA elongation from RNA polymerase II promoter 6.2754E-9 5 39 4 6292
    mRNA processing 8.7955E-9 5 156 5 6292
    RNA elongation 1.1359E-8 5 45 4 6292
    mRNA metabolic process 4.2473E-8 5 213 5 6292
    protein ubiquitination 5.1484E-8 5 65 4 6292
    regulation of transcription from RNA polymerase II promoter 5.9875E-8 5 228 5 6292
    cellular macromolecule catabolic process 1.2779E-7 5 265 5 6292
    protein modification by small protein conjugation 1.6105E-7 5 86 4 6292
    macromolecule catabolic process 2.1559E-7 5 294 5 6292
    transcription from RNA polymerase II promoter 4.1586E-7 5 335 5 6292
    protein modification by small protein conjugation or removal 5.0423E-7 5 114 4 6292
    regulation of transcription, DNA-dependent 5.8074E-7 5 358 5 6292
    regulation of RNA metabolic process 6.2268E-7 5 363 5 6292
    RNA processing 7.8377E-7 5 380 5 6292
    regulation of transcription 8.2613E-7 5 384 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.2203E-6 5 415 5 6292
    cellular catabolic process 1.2203E-6 5 415 5 6292
    regulation of nitrogen compound metabolic process 1.2352E-6 5 416 5 6292
    regulation of gene expression 1.7328E-6 5 445 5 6292
    regulation of macromolecule biosynthetic process 1.9589E-6 5 456 5 6292
    regulation of cellular biosynthetic process 2.3293E-6 5 472 5 6292
    regulation of biosynthetic process 2.3542E-6 5 473 5 6292
    regulation of macromolecule metabolic process 2.7537E-6 5 488 5 6292
    catabolic process 2.9879E-6 5 496 5 6292
    transcription, DNA-dependent 3.2057E-6 5 503 5 6292
    RNA biosynthetic process 3.3689E-6 5 508 5 6292
    regulation of primary metabolic process 3.5735E-6 5 514 5 6292
    regulation of cellular metabolic process 4.4101E-6 5 536 5 6292
    regulation of metabolic process 4.8834E-6 5 547 5 6292
    transcription 5.1116E-6 5 552 5 6292
    regulation of cellular process 3.2051E-5 5 796 5 6292
    regulation of biological process 3.8116E-5 5 824 5 6292
    post-translational protein modification 4.8711E-5 5 357 4 6292
    conjugation with cellular fusion 7.4362E-5 5 125 3 6292
    conjugation 7.6158E-5 5 126 3 6292
    RNA metabolic process 7.942E-5 5 954 5 6292
    multi-organism process 1.1119E-4 5 143 3 6292
    protein modification process 1.8329E-4 5 499 4 6292
    cellular macromolecule biosynthetic process 2.3732E-4 5 1187 5 6292
    macromolecule biosynthetic process 2.3933E-4 5 1189 5 6292
    biological regulation 2.6452E-4 5 1213 5 6292
    macromolecule modification 3.0739E-4 5 569 4 6292
    gene expression 3.5034E-4 5 1283 5 6292
    sexual reproduction 4.7442E-4 5 233 3 6292
    nucleic acid metabolic process 5.7208E-4 5 1415 5 6292
    negative regulation of transcription from RNA polymerase II promoter 8.7794E-4 5 60 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.5045E-4 5 1566 5 6292
    cellular biosynthetic process 9.5349E-4 5 1567 5 6292
    biosynthetic process 1.065E-3 5 1602 5 6292
    reproduction 1.2977E-3 5 328 3 6292
    response to pheromone involved in conjugation with cellular fusion 1.4064E-3 5 76 2 6292
    cellular nitrogen compound metabolic process 1.7545E-3 5 1770 5 6292
    nitrogen compound metabolic process 1.8612E-3 5 1791 5 6292
    response to pheromone 2.2823E-3 5 97 2 6292
    cellular response to chemical stimulus 2.7709E-3 5 107 2 6292
    cellular protein metabolic process 3.6498E-3 5 1074 4 6292
    response to organic substance 4.5082E-3 5 137 2 6292
    protein metabolic process 4.528E-3 5 1136 4 6292
    negative regulation of transcription, DNA-dependent 5.8881E-3 5 157 2 6292
    negative regulation of RNA metabolic process 5.9617E-3 5 158 2 6292
    cellular macromolecule metabolic process 6.2991E-3 5 2285 5 6292
    negative regulation of transcription 6.4122E-3 5 164 2 6292
    negative regulation of gene expression 6.4122E-3 5 164 2 6292
    macromolecule metabolic process 7.2329E-3 5 2349 5 6292
    negative regulation of macromolecule biosynthetic process 7.2782E-3 5 175 2 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7.6888E-3 5 180 2 6292
    negative regulation of nitrogen compound metabolic process 7.6888E-3 5 180 2 6292
    negative regulation of biosynthetic process 8.4546E-3 5 189 2 6292
    negative regulation of cellular biosynthetic process 8.4546E-3 5 189 2 6292
    negative regulation of macromolecule metabolic process 8.7174E-3 5 192 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    3'-5'-exoribonuclease activity 4.1011E-13 5 23 5 6292
    exoribonuclease activity 8.0172E-13 5 26 5 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 8.0172E-13 5 26 5 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3.3913E-12 5 34 5 6292
    3'-5' exonuclease activity 3.9566E-12 5 35 5 6292
    exonuclease activity 1.6707E-11 5 46 5 6292
    ribonuclease activity 6.97E-9 5 149 5 6292
    ubiquitin-protein ligase activity 3.0068E-8 5 57 4 6292
    nuclease activity 3.0132E-8 5 199 5 6292
    small conjugating protein ligase activity 4.2436E-8 5 62 4 6292
    acid-amino acid ligase activity 7.3829E-8 5 71 4 6292
    ligase activity, forming carbon-nitrogen bonds 2.3103E-7 5 94 4 6292
    hydrolase activity, acting on ester bonds 4.547E-7 5 341 5 6292
    ligase activity 1.5239E-6 5 150 4 6292
    hydrolase activity 6.3032E-5 5 911 5 6292
    catalytic activity 4.6443E-3 5 2150 5 6292

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