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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 140.30.20
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ASE1
  • spindle midzone
  • spindle
  • nuclear microtubule
  • mitotic spindle elongation
  • microtubule bundle formation
  • mitotic anaphase B
  • mitotic spindle organization in nucleus
  • mitotic spindle stabilization
  • microtubule binding
  • ATG4
  • microtubule associated complex
  • autophagy
  • C-terminal protein lipidation
  • protein targeting to vacuole
  • cysteine-type endopeptidase activity
  • microtubule binding
  • ATG8
  • pre-autophagosomal structure
  • autophagic vacuole
  • microtubule associated complex
  • autophagy
  • C-terminal protein lipidation
  • protein targeting to vacuole
  • microtubule binding
  • BIK1
  • spindle microtubule
  • cell cortex
  • spindle pole body
  • spindle
  • condensed nuclear chromosome kinetochore
  • kinetochore
  • mitotic spindle elongation
  • mitotic anaphase B
  • mitotic spindle organization in nucleus
  • karyogamy involved in conjugation with cellular fusion
  • microtubule binding
  • BIM1
  • spindle pole body
  • kinetochore
  • cytoplasmic microtubule
  • mitotic cell cycle spindle assembly checkpoint
  • microtubule nucleation
  • mitotic sister chromatid cohesion
  • nuclear migration along microtubule
  • negative regulation of microtubule depolymerization
  • microtubule depolymerization
  • structural constituent of cytoskeleton
  • CBF5
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • rRNA pseudouridine synthesis
  • ribosome biogenesis
  • pseudouridylate synthase activity
  • CIN2
  • cellular_component
  • microtubule-based process
  • molecular_function
  • CIN4
  • cytoplasm
  • microtubule-based process
  • GTP binding
  • MHP1
  • microtubule
  • cellular cell wall organization
  • negative regulation of microtubule depolymerization
  • structural constituent of cytoskeleton
  • RBL2
  • cytoplasm
  • post-chaperonin tubulin folding pathway
  • microtubule cytoskeleton organization
  • tubulin binding
  • beta-tubulin binding
  • SPC98
  • inner plaque of spindle pole body
  • gamma-tubulin small complex, spindle pole body
  • outer plaque of spindle pole body
  • microtubule nucleation
  • mitotic spindle organization in nucleus
  • structural constituent of cytoskeleton
  • STU1
  • spindle pole body
  • microtubule nucleation
  • structural constituent of cytoskeleton
  • STU2
  • spindle microtubule
  • cell cortex
  • spindle pole body
  • condensed nuclear chromosome kinetochore
  • kinetochore
  • microtubule nucleation
  • mitotic spindle organization in nucleus
  • structural constituent of cytoskeleton
  • microtubule binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    microtubule cytoskeleton 1.4475E-13 14 106 9 6292
    cytoskeletal part 5.0602E-11 14 201 9 6292
    cytoskeleton 9.6882E-11 14 216 9 6292
    microtubule 4.019E-9 14 31 5 6292
    spindle 1.8532E-8 14 89 6 6292
    microtubule organizing center 1.6E-7 14 63 5 6292
    spindle pole body 1.6E-7 14 63 5 6292
    non-membrane-bounded organelle 2.2878E-7 14 959 11 6292
    intracellular non-membrane-bounded organelle 2.2878E-7 14 959 11 6292
    spindle pole 2.3587E-7 14 68 5 6292
    kinetochore 2.7851E-4 14 60 3 6292
    chromosome, centromeric region 3.8632E-4 14 67 3 6292
    spindle microtubule 6.135E-4 14 17 2 6292
    microtubule associated complex 6.8931E-4 14 18 2 6292
    protein complex 1.1859E-3 14 1137 8 6292
    intracellular organelle part 1.5376E-3 14 2282 11 6292
    organelle part 1.5376E-3 14 2282 11 6292
    macromolecular complex 2.8523E-3 14 1635 9 6292
    box H/ACA snoRNP complex 4.4455E-3 14 2 1 6292
    autophagic vacuole 4.4455E-3 14 2 1 6292
    condensed nuclear chromosome kinetochore 5.0935E-3 14 49 2 6292
    condensed chromosome kinetochore 5.0935E-3 14 49 2 6292
    condensed chromosome, centromeric region 6.383E-3 14 55 2 6292
    condensed nuclear chromosome, centromeric region 6.383E-3 14 55 2 6292
    gamma-tubulin complex 6.6614E-3 14 3 1 6292
    gamma-tubulin small complex 6.6614E-3 14 3 1 6292
    gamma-tubulin small complex, spindle pole body 6.6614E-3 14 3 1 6292
    inner plaque of spindle pole body 8.8726E-3 14 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    microtubule-based process 1.8281E-15 14 111 10 6292
    microtubule cytoskeleton organization 6.6316E-12 14 97 8 6292
    cytoskeleton organization 7.2676E-9 14 231 8 6292
    negative regulation of microtubule polymerization or depolymerization 8.7489E-8 14 5 3 6292
    regulation of microtubule depolymerization 8.7489E-8 14 5 3 6292
    negative regulation of microtubule depolymerization 8.7489E-8 14 5 3 6292
    microtubule nucleation 1.3261E-7 14 23 4 6292
    microtubule depolymerization 1.7475E-7 14 6 3 6292
    mitotic spindle organization in nucleus 2.2303E-7 14 26 4 6292
    negative regulation of protein complex disassembly 3.0541E-7 14 7 3 6292
    negative regulation of cytoskeleton organization 4.8801E-7 14 8 3 6292
    protein depolymerization 1.043E-6 14 10 3 6292
    regulation of protein complex disassembly 1.043E-6 14 10 3 6292
    mitotic spindle organization 2.8225E-6 14 48 4 6292
    spindle organization 3.0695E-6 14 49 4 6292
    regulation of microtubule polymerization or depolymerization 5.8562E-6 14 17 3 6292
    regulation of microtubule cytoskeleton organization 5.8562E-6 14 17 3 6292
    regulation of microtubule-based process 5.8562E-6 14 17 3 6292
    microtubule polymerization or depolymerization 7.0183E-6 14 18 3 6292
    regulation of cytoskeleton organization 9.7792E-6 14 20 3 6292
    negative regulation of cellular component organization 3.0977E-5 14 29 3 6292
    negative regulation of organelle organization 3.0977E-5 14 29 3 6292
    C-terminal protein lipidation 4.5804E-5 14 5 2 6292
    peptide or protein carboxyl-terminal blocking 6.8619E-5 14 6 2 6292
    mitotic anaphase B 6.8619E-5 14 6 2 6292
    cellular protein complex disassembly 7.6464E-5 14 39 3 6292
    protein complex disassembly 7.6464E-5 14 39 3 6292
    cellular macromolecular complex disassembly 8.2555E-5 14 40 3 6292
    macromolecular complex disassembly 8.2555E-5 14 40 3 6292
    anaphase 9.5944E-5 14 7 2 6292
    mitotic anaphase 9.5944E-5 14 7 2 6292
    cellular component disassembly 1.1008E-4 14 44 3 6292
    mitotic cell cycle 1.5578E-4 14 255 5 6292
    regulation of organelle organization 1.8177E-4 14 52 3 6292
    M phase 3.0414E-4 14 294 5 6292
    regulation of cellular component organization 5.3883E-4 14 75 3 6292
    mitotic spindle elongation 9.4251E-4 14 21 2 6292
    spindle elongation 9.4251E-4 14 21 2 6292
    cell cycle phase 9.4749E-4 14 376 5 6292
    organelle organization 1.1158E-3 14 1127 8 6292
    mitosis 1.3987E-3 14 104 3 6292
    nuclear division 1.4779E-3 14 106 3 6292
    organelle fission 1.7771E-3 14 113 3 6292
    microtubule bundle formation 2.225E-3 14 1 1 6292
    M phase of mitotic cell cycle 2.5404E-3 14 128 3 6292
    cell cycle process 3.109E-3 14 490 5 6292
    autophagy 3.7625E-3 14 42 2 6292
    cell cycle 4.2068E-3 14 525 5 6292
    regulation of spindle organization 4.4455E-3 14 2 1 6292
    regulation of mitotic spindle organization 4.4455E-3 14 2 1 6292
    spindle stabilization 4.4455E-3 14 2 1 6292
    mitotic spindle stabilization 4.4455E-3 14 2 1 6292
    lipoprotein metabolic process 5.7214E-3 14 52 2 6292
    lipoprotein biosynthetic process 5.7214E-3 14 52 2 6292
    protein amino acid lipidation 5.7214E-3 14 52 2 6292
    cellular process 7.2188E-3 14 4426 14 6292
    rRNA pseudouridine synthesis 8.8726E-3 14 4 1 6292
    post-chaperonin tubulin folding pathway 8.8726E-3 14 4 1 6292
    protein targeting to vacuole 9.9063E-3 14 69 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    tubulin binding 1.3333E-12 14 20 6 6292
    microtubule binding 6.1122E-12 14 10 5 6292
    cytoskeletal protein binding 1.4851E-9 14 59 6 6292
    structural constituent of cytoskeleton 6.6112E-8 14 53 5 6292
    structural molecule activity 5.8916E-4 14 339 5 6292
    protein binding 1.2532E-3 14 612 6 6292
    beta-tubulin binding 4.4455E-3 14 2 1 6292
    cysteine-type endopeptidase activity 8.8726E-3 14 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle