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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 4 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
SSL1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFB1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFB3
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFB4
  • holo TFIIH complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    holo TFIIH complex 3.2188E-12 4 10 4 6292
    nucleotide-excision repair factor 3 complex 3.3722E-9 4 7 3 6292
    DNA-directed RNA polymerase II, holoenzyme 5.6296E-9 4 56 4 6292
    transcription factor complex 1.4893E-8 4 71 4 6292
    nucleotide-excision repair complex 1.2793E-7 4 21 3 6292
    nucleoplasm part 2.2451E-6 4 245 4 6292
    nucleoplasm 3.0322E-6 4 264 4 6292
    nuclear lumen 2.6539E-5 4 453 4 6292
    organelle lumen 1.2008E-4 4 660 4 6292
    intracellular organelle lumen 1.2008E-4 4 660 4 6292
    membrane-enclosed lumen 1.5203E-4 4 700 4 6292
    nuclear part 9.4015E-4 4 1103 4 6292
    protein complex 1.0617E-3 4 1137 4 6292
    macromolecular complex 4.5471E-3 4 1635 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    regulation of transcription from RNA polymerase II promoter, mitotic 1.0729E-12 4 8 4 6292
    negative regulation of transcription from RNA polymerase II promoter, mitotic 1.0729E-12 4 8 4 6292
    regulation of transcription, mitotic 1.9313E-12 4 9 4 6292
    negative regulation of transcription, mitotic 1.9313E-12 4 9 4 6292
    nucleotide-excision repair, DNA duplex unwinding 1.9272E-9 4 6 3 6292
    transcription initiation from RNA polymerase II promoter 2.7339E-9 4 47 4 6292
    transcription initiation 6.503E-9 4 58 4 6292
    negative regulation of transcription from RNA polymerase II promoter 7.4742E-9 4 60 4 6292
    DNA geometric change 1.0967E-7 4 20 3 6292
    DNA duplex unwinding 1.0967E-7 4 20 3 6292
    protein complex biogenesis 3.5452E-7 4 155 4 6292
    protein complex assembly 3.5452E-7 4 155 4 6292
    negative regulation of transcription, DNA-dependent 3.7337E-7 4 157 4 6292
    negative regulation of RNA metabolic process 3.8306E-7 4 158 4 6292
    negative regulation of gene expression 4.4528E-7 4 164 4 6292
    negative regulation of transcription 4.4528E-7 4 164 4 6292
    negative regulation of macromolecule biosynthetic process 5.7866E-7 4 175 4 6292
    negative regulation of nitrogen compound metabolic process 6.483E-7 4 180 4 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6.483E-7 4 180 4 6292
    negative regulation of biosynthetic process 7.8928E-7 4 189 4 6292
    negative regulation of cellular biosynthetic process 7.8928E-7 4 189 4 6292
    nucleotide-excision repair 8.0979E-7 4 38 3 6292
    negative regulation of macromolecule metabolic process 8.4103E-7 4 192 4 6292
    negative regulation of cellular metabolic process 1.1839E-6 4 209 4 6292
    negative regulation of metabolic process 1.2069E-6 4 210 4 6292
    regulation of transcription from RNA polymerase II promoter 1.6808E-6 4 228 4 6292
    negative regulation of cellular process 2.4353E-6 4 250 4 6292
    negative regulation of biological process 2.555E-6 4 253 4 6292
    DNA conformation change 2.9548E-6 4 58 3 6292
    macromolecular complex assembly 3.8974E-6 4 281 4 6292
    transcription from RNA polymerase II promoter 7.9001E-6 4 335 4 6292
    macromolecular complex subunit organization 1.02E-5 4 357 4 6292
    regulation of transcription, DNA-dependent 1.0315E-5 4 358 4 6292
    regulation of RNA metabolic process 1.0906E-5 4 363 4 6292
    regulation of transcription 1.367E-5 4 384 4 6292
    cellular component assembly 1.3814E-5 4 385 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.867E-5 4 415 4 6292
    regulation of nitrogen compound metabolic process 1.8852E-5 4 416 4 6292
    regulation of gene expression 2.4707E-5 4 445 4 6292
    regulation of macromolecule biosynthetic process 2.7251E-5 4 456 4 6292
    regulation of cellular biosynthetic process 3.1296E-5 4 472 4 6292
    regulation of biosynthetic process 3.1563E-5 4 473 4 6292
    regulation of macromolecule metabolic process 3.5776E-5 4 488 4 6292
    transcription, DNA-dependent 4.0396E-5 4 503 4 6292
    RNA biosynthetic process 4.2031E-5 4 508 4 6292
    regulation of primary metabolic process 4.4059E-5 4 514 4 6292
    regulation of cellular metabolic process 5.2125E-5 4 536 4 6292
    regulation of metabolic process 5.655E-5 4 547 4 6292
    transcription 5.8652E-5 4 552 4 6292
    DNA repair 1.0942E-4 4 192 3 6292
    cellular component biogenesis 1.4687E-4 4 694 4 6292
    response to DNA damage stimulus 2.027E-4 4 236 3 6292
    regulation of cellular process 2.5447E-4 4 796 4 6292
    regulation of biological process 2.9228E-4 4 824 4 6292
    cellular response to stress 3.7451E-4 4 290 3 6292
    RNA metabolic process 5.2568E-4 4 954 4 6292
    cellular response to stimulus 8.288E-4 4 379 3 6292
    cellular macromolecule biosynthetic process 1.2614E-3 4 1187 4 6292
    macromolecule biosynthetic process 1.27E-3 4 1189 4 6292
    biological regulation 1.3758E-3 4 1213 4 6292
    gene expression 1.7224E-3 4 1283 4 6292
    response to stress 1.8449E-3 4 497 3 6292
    nucleic acid metabolic process 2.5494E-3 4 1415 4 6292
    DNA metabolic process 2.9778E-3 4 585 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.8261E-3 4 1566 4 6292
    cellular biosynthetic process 3.8359E-3 4 1567 4 6292
    cellular component organization 3.9851E-3 4 1582 4 6292
    biosynthetic process 4.1907E-3 4 1602 4 6292
    cellular nitrogen compound metabolic process 6.2471E-3 4 1770 4 6292
    response to stimulus 6.5381E-3 4 766 3 6292
    nitrogen compound metabolic process 6.5492E-3 4 1791 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    general RNA polymerase II transcription factor activity 9.7387E-9 4 64 4 6292
    RNA polymerase II transcription factor activity 1.741E-7 4 130 4 6292
    transcription regulator activity 8.286E-6 4 339 4 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle