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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Glc7. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 24 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CFT1
  • mRNA cleavage and polyadenylation specificity factor complex
  • mitochondrion
  • mRNA cleavage factor complex
  • termination of RNA polymerase II transcription
  • mRNA polyadenylation
  • mRNA cleavage
  • RNA binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • mitochondrion organization
  • molecular_function
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • FIN1
  • nucleus
  • spindle pole body
  • spindle
  • intermediate filament
  • astral microtubule
  • mitotic sister chromatid segregation
  • intermediate filament-based process
  • mitotic spindle stabilization
  • structural constituent of cytoskeleton
  • microtubule binding
  • FIP1
  • mRNA cleavage and polyadenylation specificity factor complex
  • mRNA polyadenylation
  • mRNA cleavage
  • RNA binding
  • protein binding
  • FPR3
  • nucleolus
  • meiotic recombination checkpoint
  • peptidyl-prolyl cis-trans isomerase activity
  • FPR4
  • nucleus
  • chromatin
  • chromatin silencing at rDNA
  • negative regulation of histone H3-K36 methylation
  • ribosome biogenesis
  • histone peptidyl-prolyl isomerization
  • positive regulation of transcription from RNA polymerase II promoter
  • nucleosome assembly
  • peptidyl-prolyl cis-trans isomerase activity
  • histone binding
  • GLC7
  • protein phosphatase type 1 complex
  • mRNA cleavage and polyadenylation specificity factor complex
  • cellular bud neck
  • spindle pole body
  • nuclear outer membrane
  • nucleolus
  • mating projection base
  • mitotic cell cycle spindle assembly checkpoint
  • cell morphogenesis during vegetative growth
  • protein amino acid dephosphorylation
  • chromosome segregation
  • cell budding
  • cellular ion homeostasis
  • meiosis
  • regulation of carbohydrate metabolic process
  • ascospore formation
  • response to heat
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • glycogen metabolic process
  • termination of RNA polymerase II transcription, poly(A)-independent
  • histone dephosphorylation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • RNA binding
  • metal ion binding
  • hydrolase activity
  • GLC8
  • nucleus
  • cytoplasm
  • glycogen biosynthetic process
  • chromosome segregation
  • enzyme activator activity
  • GPH1
  • cytoplasm
  • glycogen catabolic process
  • glycogen phosphorylase activity
  • HER1
  • cytoplasm
  • mitochondrion
  • ribosome
  • biological_process
  • molecular_function
  • KEL1
  • cellular bud tip
  • cytoplasm
  • cellular bud neck
  • mating projection tip
  • regulation of cell shape
  • negative regulation of exit from mitosis
  • cell morphogenesis
  • cytogamy
  • plasma membrane fusion
  • molecular_function
  • MHP1
  • microtubule
  • cellular cell wall organization
  • negative regulation of microtubule depolymerization
  • structural constituent of cytoskeleton
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • REG1
  • protein phosphatase type 1 complex
  • cytoplasm
  • negative regulation of transcription from RNA polymerase II promoter
  • regulation of carbohydrate metabolic process
  • glycogen metabolic process
  • vacuolar protein catabolic process
  • protein phosphatase type 1 regulator activity
  • RRP17
  • cytoplasm
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • SCD5
  • peripheral to membrane of membrane fraction
  • actin cortical patch
  • cortical actin cytoskeleton organization
  • actin filament organization
  • endocytosis
  • protein secretion
  • protein binding
  • SDS22
  • nucleus
  • cytoplasm
  • protein targeting
  • chromosome segregation
  • protein phosphatase type 1 regulator activity
  • enzyme regulator activity
  • SEN1
  • nucleus
  • nuclear outer membrane
  • snRNA processing
  • tRNA processing
  • snoRNA processing
  • transcription termination
  • termination of RNA polymerase II transcription
  • DNA-dependent ATPase activity
  • RNA helicase activity
  • RNA-dependent ATPase activity
  • RNA polymerase II transcription termination factor activity
  • 5'-3' DNA helicase activity
  • SPB1
  • nucleus
  • nucleolus
  • rRNA methylation
  • processing of 27S pre-rRNA
  • rRNA (uridine-2'-O-)-methyltransferase activity
  • rRNA (guanine) methyltransferase activity
  • SUI2
  • multi-eIF complex
  • cytoplasm
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • SUI3
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    non-membrane-bounded organelle 1.4599E-6 24 959 14 6292
    intracellular non-membrane-bounded organelle 1.4599E-6 24 959 14 6292
    nucleolus 9.1897E-6 24 211 7 6292
    mRNA cleavage and polyadenylation specificity factor complex 2.1535E-5 24 15 3 6292
    nuclear lumen 2.3642E-5 24 453 9 6292
    eukaryotic translation initiation factor 2 complex 4.1739E-5 24 3 2 6292
    mRNA cleavage factor complex 5.3284E-5 24 20 3 6292
    protein phosphatase type 1 complex 2.8946E-4 24 7 2 6292
    multi-eIF complex 3.8504E-4 24 8 2 6292
    organelle lumen 4.4544E-4 24 660 9 6292
    intracellular organelle lumen 4.4544E-4 24 660 9 6292
    membrane-enclosed lumen 6.9113E-4 24 700 9 6292
    protein serine/threonine phosphatase complex 1.8314E-3 24 17 2 6292
    intracellular part 2.9448E-3 24 4938 24 6292
    intracellular 3.5241E-3 24 4975 24 6292
    astral microtubule 3.8144E-3 24 1 1 6292
    aster 3.8144E-3 24 1 1 6292
    nuclear part 4.7945E-3 24 1103 10 6292
    protein complex 6.0045E-3 24 1137 10 6292
    microtubule 6.0611E-3 24 31 2 6292
    cytoskeletal part 6.5009E-3 24 201 4 6292
    microtubule cytoskeleton 7.2724E-3 24 106 3 6292
    intermediate filament 7.6148E-3 24 2 1 6292
    intermediate filament cytoskeleton 7.6148E-3 24 2 1 6292
    nucleus 7.8336E-3 24 2041 14 6292
    cytoskeleton 8.3612E-3 24 216 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein complex disassembly 2.7373E-7 24 39 5 6292
    cellular protein complex disassembly 2.7373E-7 24 39 5 6292
    cellular macromolecular complex disassembly 3.1205E-7 24 40 5 6292
    macromolecular complex disassembly 3.1205E-7 24 40 5 6292
    cellular component disassembly 5.0984E-7 24 44 5 6292
    negative regulation of organelle organization 3.6295E-6 24 29 4 6292
    negative regulation of cellular component organization 3.6295E-6 24 29 4 6292
    glycogen metabolic process 5.4534E-6 24 32 4 6292
    energy reserve metabolic process 5.4534E-6 24 32 4 6292
    regulation of cellular component organization 7.4913E-6 24 75 5 6292
    cellular glucan metabolic process 1.8198E-5 24 43 4 6292
    glucan metabolic process 1.8198E-5 24 43 4 6292
    negative regulation of cellular process 2.7843E-5 24 250 7 6292
    negative regulation of biological process 3.0079E-5 24 253 7 6292
    regulation of organelle organization 3.9015E-5 24 52 4 6292
    termination of RNA polymerase II transcription 4.5405E-5 24 19 3 6292
    cellular polysaccharide metabolic process 4.8775E-5 24 55 4 6292
    transcription termination 6.201E-5 24 21 3 6292
    polysaccharide metabolic process 6.8854E-5 24 60 4 6292
    negative regulation of microtubule polymerization or depolymerization 1.3848E-4 24 5 2 6292
    regulation of microtubule depolymerization 1.3848E-4 24 5 2 6292
    negative regulation of microtubule depolymerization 1.3848E-4 24 5 2 6292
    microtubule depolymerization 2.0724E-4 24 6 2 6292
    ribosome biogenesis 2.1938E-4 24 346 7 6292
    regulation of cell cycle process 2.2266E-4 24 81 4 6292
    negative regulation of cell cycle process 2.2497E-4 24 32 3 6292
    negative regulation of protein complex disassembly 2.8946E-4 24 7 2 6292
    cellular macromolecular complex subunit organization 3.3027E-4 24 259 6 6292
    ribonucleoprotein complex biogenesis 3.5474E-4 24 374 7 6292
    negative regulation of cytoskeleton organization 3.8504E-4 24 8 2 6292
    translational initiation 5.0782E-4 24 42 3 6292
    regulation of protein complex disassembly 6.1594E-4 24 10 2 6292
    protein depolymerization 6.1594E-4 24 10 2 6292
    glucose metabolic process 6.9319E-4 24 109 4 6292
    hexose metabolic process 1.125E-3 24 124 4 6292
    gene expression 1.1446E-3 24 1283 12 6292
    chromosome segregation 1.2663E-3 24 128 4 6292
    regulation of cell cycle 1.3801E-3 24 131 4 6292
    monosaccharide metabolic process 1.5429E-3 24 135 4 6292
    macromolecular complex subunit organization 1.7982E-3 24 357 6 6292
    ribosomal large subunit biogenesis 1.8241E-3 24 65 3 6292
    regulation of microtubule polymerization or depolymerization 1.8314E-3 24 17 2 6292
    regulation of microtubule cytoskeleton organization 1.8314E-3 24 17 2 6292
    regulation of microtubule-based process 1.8314E-3 24 17 2 6292
    microtubule polymerization or depolymerization 2.0555E-3 24 18 2 6292
    energy derivation by oxidation of organic compounds 2.2185E-3 24 149 4 6292
    mRNA polyadenylation 2.292E-3 24 19 2 6292
    regulation of mitotic cell cycle 2.3513E-3 24 71 3 6292
    cellular process 2.3626E-3 24 4426 23 6292
    RNA processing 2.4738E-3 24 380 6 6292
    regulation of cytoskeleton organization 2.5408E-3 24 20 2 6292
    negative regulation of histone H3-K36 methylation 3.8144E-3 24 1 1 6292
    regulation of histone H3-K36 methylation 3.8144E-3 24 1 1 6292
    protein peptidyl-prolyl isomerization 3.8144E-3 24 1 1 6292
    histone peptidyl-prolyl isomerization 3.8144E-3 24 1 1 6292
    histone H3-K36 methylation 3.8144E-3 24 1 1 6292
    regulation of histone methylation 3.8144E-3 24 1 1 6292
    negative regulation of histone methylation 3.8144E-3 24 1 1 6292
    negative regulation of histone modification 3.8144E-3 24 1 1 6292
    regulation of histone modification 3.8144E-3 24 1 1 6292
    intermediate filament-based process 3.8144E-3 24 1 1 6292
    mRNA cleavage 3.9653E-3 24 25 2 6292
    RNA polyadenylation 4.2858E-3 24 26 2 6292
    generation of precursor metabolites and energy 5.8423E-3 24 195 4 6292
    mRNA 3'-end processing 6.0611E-3 24 31 2 6292
    RNA metabolic process 6.2133E-3 24 954 9 6292
    regulation of spindle organization 7.6148E-3 24 2 1 6292
    regulation of mitotic spindle organization 7.6148E-3 24 2 1 6292
    histone lysine methylation 7.6148E-3 24 2 1 6292
    meiotic prophase I 7.6148E-3 24 2 1 6292
    histone dephosphorylation 7.6148E-3 24 2 1 6292
    regulation of cell shape 7.6148E-3 24 2 1 6292
    meiotic cell cycle checkpoint 7.6148E-3 24 2 1 6292
    spindle stabilization 7.6148E-3 24 2 1 6292
    mitotic spindle stabilization 7.6148E-3 24 2 1 6292
    prophase 7.6148E-3 24 2 1 6292
    regulation of chromosome organization 7.6148E-3 24 2 1 6292
    meiotic recombination checkpoint 7.6148E-3 24 2 1 6292
    transcription from RNA polymerase II promoter 7.6304E-3 24 335 5 6292
    regulation of carbohydrate metabolic process 8.1171E-3 24 36 2 6292
    ncRNA processing 8.2273E-3 24 215 4 6292
    alcohol metabolic process 8.911E-3 24 220 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein phosphatase type 1 regulator activity 8.9917E-4 24 12 2 6292
    cis-trans isomerase activity 1.234E-3 24 14 2 6292
    peptidyl-prolyl cis-trans isomerase activity 1.234E-3 24 14 2 6292
    protein phosphatase regulator activity 3.3597E-3 24 23 2 6292
    phosphatase regulator activity 3.3597E-3 24 23 2 6292
    glycogen phosphorylase activity 3.8144E-3 24 1 1 6292
    phosphorylase activity 3.8144E-3 24 1 1 6292
    RNA polymerase II transcription termination factor activity 3.8144E-3 24 1 1 6292
    translation initiation factor activity 4.6179E-3 24 27 2 6292
    transcription termination factor activity 7.6148E-3 24 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle