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Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: eukaryotic translation initiation factor 3 complex
Acc: GO:0005852
Aspect: Cellular Component
Desc: A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Synonyms:
  • eIF-3
  • eIF3
Proteins in PDR annotated with:
   This term: 86 [Search]
   Term or descendants: 86 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005852 - eukaryotic translation initiation factor 3 complex (interactive image map)
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