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Protein Overview: LOS1

General Information:
Name(s) found: LOS1 / YKL205W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1100 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    nuclear matrix [IDALink to PubMed article]
    Biological Process: tRNA export from nucleus [IMPLink to PubMed article]
    tRNA splicing, via endonucleolytic cleavage and ligation [IMPLink to PubMed article]
    Molecular Function: tRNA binding [TASLink to PubMed article]
    Ran GTPase binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLERIQQLVN AVNDPRSDVA TKRQAIELLN GIKSSENALE IFISLVINEN SNDLLKFYGL  60
   61 STLIELMTEG VNANPNGLNL VKFEITKWLK FQVLGNKQTK LPDFLMNKIS EVLTTLFMLM 120
  121 YSDCNGNQWN SFFDDLMSLF QVDSAISNTS PSTDGNILLG LEFFNKLCLM INSEIADQSF 180
  181 IRSKESQLKN NNIKDWMRDN DIMKLSNVWF QCLKLDEQIV SQCPGLINST LDCIGSFISW 240
  241 IDINLIIDAN NYYLQLIYKF LNLKETKISC YNCILAIISK KMKPMDKLAF LNMINLTNEL 300
  301 TYYHQAISMN PQIITFDNLE VWESLTKLIT SFGIEFTIII EQVNDDQKLD TLYKQSVISN 360
  361 VDSILLEKII PILLEFMNNE FDSITAKTFP FWSNYLAFLK KYKASSPNFV PLHKDFLDNF 420
  421 QQICFKRMKF SDDEVTQDDF EEFNETVRFK LKNFQEIIVV IDPSLFLNNI SQEISANLMN 480
  481 CKNESWQIFE LTIYQIFNLS ECTKNNYFGL NKNEIMTSQP SLTLVRFLNE LLMMKDFLLA 540
  541 IDNEQIQILF MELIVKNYNF IFSTSANTAN ATDDDEKYLL ILNIFMSSFA MFNKRENVRL 600
  601 RSWYLFTRFL KLTRINLKKI LFANKNLVNE ITNKISPLLH IKVTSINAQG TDDNDTIFDN 660
  661 QLYIFEGIGF IITLNNSSQE LTAATANTPI DYDILDQILT PLFTQLEGCI TQGASPVVIL 720
  721 ECHHILMAIG TLARGLHIGL VPENQVNNMV VNKKLINDSL IHKFSNIAEV ILVTFSFFNK 780
  781 FENIRDASRF TFARLIPILS NKILPFINKL IELILSSTDL KSWEMIDFLG FLSQLIHMFH 840
  841 TDTDCYQLFN QLLTPLINKV HSIIEEIDEQ HDQQSSSNKP IDTAVTATSV NKNIVVTDSY 900
  901 RDKILLKKAY CTFLQSFTNN SVTSILLSDI NRAILPVILN DLVTYTPQEI QETSMMKVSL 960
  961 NVLCNFIKCF GNGTCLDNDD INKDPNLKID GLNEYFIMKC VPIIFEIPFN PIYKFNIKEG1020
 1021 NFKTMAYDLA RLLRELFIVS SNPTTNENEC VKYLTQIYLP QIQLPQELTI QLVNMLTTMG1080
 1081 QKQFEKWFVD NFISVLKQGQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LOS1 SEN15 SEN2 SEN34 SEN54 STP1 STP2 STP3 STP4 TPT1 TRL1
    View Details Ho Y, et al. (2002) ATP4 FAA4 FET3 GCD1 GCD11 GCD2 GCD6 GCD7 GCN1 GCN3 LOS1 MET18 NMD5 POL5 PRO3 RVB1 SCW4 SEC7 SUI3 TMA19 UBA1 UBC6 UTP20 VAC8 VMA8 YPT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LOS1 PNC1 2 Unpublished Fields Lab Data
    View Screen LOS1 NIF3 2 Unpublished Fields Lab Data
    View Screen LOS1 RPC25 2 Uetz P, et al. (2000)
    View Screen LOS1 WTM2 2 Unpublished Fields Lab Data
    View Screen LOS1 SOR2 2 Unpublished Fields Lab Data
    View Screen LOS1 HMO1 2 Unpublished Fields Lab Data
    View Screen LOS1 DNM1 2 Unpublished Fields Lab Data
    View Screen LOS1 DYN2 2 Unpublished Fields Lab Data
    View Screen LOS1 SRL2 2 Unpublished Fields Lab Data
    View Screen LOS1 ERG10 2 Unpublished Fields Lab Data
    View Screen LOS1 LAP3 2 Unpublished Fields Lab Data
    View Screen LOS1 TDH1 2 Unpublished Fields Lab Data
    View Screen LOS1 DIG1 2 Unpublished Fields Lab Data
    View Screen LOS1 EDC3 2 Unpublished Fields Lab Data
    View Screen LOS1 YJL114W 2 Unpublished Fields Lab Data
    View Screen LOS1 PRO3 2 Unpublished Fields Lab Data
    View Screen LOS1 TDH2 2 Unpublished Fields Lab Data
    View Screen LOS1 ATG16 2 Unpublished Fields Lab Data
    View Screen LOS1 HSP10 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LOS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..434] MSA 11.053947 View MSA. No confident structure predictions are available.
    2 View Details [435..516] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [517..1100] MSA 1.014975 View MSA. No confident structure predictions are available.
    4 View Details [1013..1100] MSA 1.031986 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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