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Protein Overview: PNC1

General Information:
Name(s) found: PNC1 / YGL037C [SGD]
Description(s) found:
Found 37 descriptions.
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  • Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 216 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    peroxisome [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: chromatin silencing at rDNA [IMPLink to PubMed article]
    replicative cell aging [IEPLink to PubMed article][IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    nicotinate nucleotide salvage [ISSLink to PubMed article]
    Molecular Function: nicotinamidase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTLIVVDMQ NDFISPLGSL TVPKGEELIN PISDLMQDAD RDWHRIVVTR DWHPSRHISF  60
   61 AKNHKDKEPY STYTYHSPRP GDDSTQEGIL WPVHCVKNTW GSQLVDQIMD QVVTKHIKIV 120
  121 DKGFLTDREY YSAFHDIWNF HKTDMNKYLE KHHTDEVYIV GVALEYCVKA TAISAAELGY 180
  181 KTTVLLDYTR PISDDPEVIN KVKEELKAHN INVVDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GPD1 PNC1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LOS1 PNC1 2 Unpublished Fields Lab Data
    View Screen NUP1 PNC1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PNC1 and PEX3 Huh WK, et al. (2003)
    View Data PNC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] PSI-BLAST 312.9897 Pyrazinamidase/nicotinamidase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle