Protein Overview: w-PA

General Information:
Name(s) found:	w-PA / FBpp0070468 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7290367\|gb\|AAF45826.1\| white [Drosophila melanogaster] [NCBI NR] gi\|6691813\|emb\|CAB65847.1\| EG:BACN33B1.1 [Drosophila melanogaster] [NCBI NR] gi\|17136592\|ref\|NP_476787.1\| white [Drosophila melanogaster] [NCBI NR] The gene white is referred to in FlyBase by the symbol Dmel\w (CG2759, FBgn0003996). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2684632..2690499. It has the cytological map location 3B6. Based on sequence similarity, it is predicted to have molecular function</span>: ATPase activity, coupled to transmembrane movement of substances. There is experimental evidence that it is involved in the biological process</span>: cellular biogenic amine biosynthetic process; memory; compound eye pigmentation; cGMP transport; ommochrome biosynthetic process. 1729 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; peripheral nervous system; external compound sense organ; nervous system; Malpighian tubule; compound cell cluster organ; Malpighian tubule segment; larval excretory system; adult; adult cuticle; integumentary plate. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG2759-PA translation from_gene[CG2759 w FBgn0003996] seq_release:3 mol_weight=75717 cds_boundaries:(X:2,547,504..2,553,080[-]) aa_length:687 transcript_info:[CG2759-RA seq_release:3] gene_info:[gene symbol:w FBgn0003996 gene_boundaries:(X:2,547,371.. [hmr_yeast5_DM3-1_pombe.fasta] (AE003425) w gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG2759-PA [Drosophila melanogaster]gi\|17136592\|ref\|NP_476787.1\| CG2759-PA [Drosophila melanogaster]gi\|6691813\|emb\|CAB65847.1\| EG:BACN33B1.1 [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] CG2759-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=X:complement(2684762..2685376,2685447..2685578,2685782..2686097,2686159..2686813,2686888..2687161,2690270..2690341); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,G [fly-100309-contam.fasta] white CG2759-PA [Drosophila melanogaster] [nr-271106-contam.fasta] EG:BACN33B1.1 [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=X:complement(2684762..2685376,2685447..2685578,2685782..2686097,2686159..2686813,2686888..2687161,2690270..2690341); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,GB_protein:AAF45826.1,REFSEQ:NP_476787,GB_protein:AAF45826; MD5=4ad27343281e3a6e4b956c96efdd0ef5; length=687; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:complement(2684762..2685376,2685447..2685578,2685782..2686097,2686159..2686813,2686888..2687161,2690270..2690341); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,GB_protein:AAF45826.1,REFSEQ:NP_476787,GB_protein:AAF45826; MD5=4ad27343281e3a6e4b956c96efdd0ef5; length=687; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=X:complement(2684762..2685376,2685447..2685578,2685782..2686097,2686159..2686813,2686888..2687161,2690270..2690341); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,GB_protein:AAF45826.1,REFSEQ:NP_476787,GB_protein:AAF45826,FlyMine:FBpp0070468,modMine:FBpp0070468; MD5=4ad27343281e3a6e4b956c96efdd0ef5; length=687; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:complement(join(2796237..2796308,2792855..2793128,2792126..2792780,2791749..2792064,2791414..2791545,2790729..2791343)); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,GB_protein:AAF45826.1,REFSEQ:NP_476787,GB_protein:AAF45826,FlyMine:FBpp0070468,modMine:FBpp0070468; MD5=4ad27343281e3a6e4b956c96efdd0ef5; length=687; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:complement(join(2796237..2796308,2792855..2793128,2792126..2792780,2791749..2792064,2791414..2791545,2790729..2791343)); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,GB_protein:AAF45826.1,REFSEQ:NP_476787,GB_protein:AAF45826,FlyMine:FBpp0070468,modMine:FBpp0070468; MD5=4ad27343281e3a6e4b956c96efdd0ef5; length=687; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0070468 type=protein; loc=X:complement(join(2796237..2796308,2792855..2793128,2792126..2792780,2791749..2792064,2791414..2791545,2790729..2791343)); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,GB_protein:AAF45826.1,REFSEQ:NP_476787,GB_protein:AAF45826,FlyMine:FBpp0070468,modMine:FBpp0070468; MD5=4ad27343281e3a6e4b956c96efdd0ef5; length=687; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:complement(join(2796237..2796308,2792855..2793128,2792126..2792780,2791749..2792064,2791414..2791545,2790729..2791343)); ID=FBpp0070468; name=w-PA; parent=FBgn0003996,FBtr0070490; dbxref=FlyBase:FBpp0070468,FlyBase_Annotation_IDs:CG2759-PA,GB_protein:AAF45826.1,REFSEQ:NP_476787,GB_protein:AAF45826,UniProt/Swiss-Prot:P10090,FlyMine:FBpp0070468,modMine:FBpp0070468; MD5=4ad27343281e3a6e4b956c96efdd0ef5; length=687; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	687 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQEDQELLI RGGSKHPSAE HLNNGDSGAA SQSCINQGFG QAKNYGTLRP PSPPEDSGSG  60
   61 SGQLAENLTY AWHNMDIFGA VNQPGSGWRQ LVNRTRGLFC NERHIPAPRK HLLKNVCGVA 120
  121 YPGELLAVMG SSGAGKTTLL NALAFRSPQG IQVSPSGMRL LNGQPVDAKE MQARCAYVQQ 180
  181 DDLFIGSLTA REHLIFQAMV RMPRHLTYRQ RVARVDQVIQ ELSLSKCQHT IIGVPGRVKG 240
  241 LSGGERKRLA FASEALTDPP LLICDEPTSG LDSFTAHSVV QVLKKLSQKG KTVILTIHQP 300
  301 SSELFELFDK ILLMAEGRVA FLGTPSEAVD FFSYVGAQCP TNYNPADFYV QVLAVVPGRE 360
  361 IESRDRIAKI CDNFAISKVA RDMEQLLATK NLEKPLEQPE NGYTYKATWF MQFRAVLWRS 420
  421 WLSVLKEPLL VKVRLIQTTM VAILIGLIFL GQQLTQVGVM NINGAIFLFL TNMTFQNVFA 480
  481 TINVFTSELP VFMREARSRL YRCDTYFLGK TIAELPLFLT VPLVFTAIAY PMIGLRAGVL 540
  541 HFFNCLALVT LVANVSTSFG YLISCASSST SMALSVGPPV IIPFLLFGGF FLNSGSVPVY 600
  601 LKWLSYLSWF RYANEGLLIN QWADVEPGEI SCTSSNTTCP SSGKVILETL NFSAADLPLD 660
  661 YVGLAILIVS FRVLAYLALR LRARRKE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..96]	PSI-BLAST	55.522879	No description for 2hydA was found.
2	View Details	[97..452]	PSI-BLAST	68.69897	Crystal structure of E. coli MalK in the nucleotide-free form
3	View Details	[453..687]	Pfam	26.721246	No description for PF01061.15 was found. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity	6.58863529263644	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	6.58067278719409	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	6.57974651657836	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	6.57922174989907	bayes_pls_golite062009
primary active transmembrane transporter activity	6.57807080367604	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.48406410175216	bayes_pls_golite062009
active transmembrane transporter activity	6.48154954364331	bayes_pls_golite062009
pyrophosphatase activity	6.40467109535527	bayes_pls_golite062009
ATPase activity, coupled	6.40151534181487	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.38373914253885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.38247436082206	bayes_pls_golite062009
ATPase activity	6.30019941712404	bayes_pls_golite062009
hydrolase activity	5.13885856289543	bayes_pls_golite062009
heme transporter activity	4.82479229680991	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	4.71935767060308	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	4.35344629015015	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	4.18204040663138	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	4.18204040663138	bayes_pls_golite062009
ribonucleotide binding	3.79710854336074	bayes_pls_golite062009
purine ribonucleotide binding	3.7956093726294	bayes_pls_golite062009
ATP binding	3.78352939926331	bayes_pls_golite062009
purine nucleotide binding	3.74676466237472	bayes_pls_golite062009
adenyl ribonucleotide binding	3.73153142187361	bayes_pls_golite062009
nucleotide binding	3.71970404557651	bayes_pls_golite062009
adenyl nucleotide binding	3.66815111788068	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.19399273923292	bayes_pls_golite062009
anion transmembrane transporter activity	3.13913638619234	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.9271291809464	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.88795687640992	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
cholesterol transporter activity	2.72457626066894	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.63419811368692	bayes_pls_golite062009
sterol transporter activity	2.48406559423479	bayes_pls_golite062009
cofactor transporter activity	2.41442360192472	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
transcription regulator activity	2.32253394491642	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
eye pigment precursor transporter activity	2.19742277986318	bayes_pls_golite062009
molybdenum ion binding	2.14174749204485	bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity	2.02835630285647	bayes_pls_golite062009
DNA binding	1.998202240501	bayes_pls_golite062009
transporter activity	1.9862037182943	bayes_pls_golite062009
lipopolysaccharide transmembrane transporter activity	1.92426772294655	bayes_pls_golite062009
lipopolysaccharide-transporting ATPase activity	1.92426772294655	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
polysaccharide transmembrane transporter activity	1.87680514870933	bayes_pls_golite062009
phosphate transmembrane transporter activity	1.85306856438851	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
organic anion transmembrane transporter activity	1.76999970080179	bayes_pls_golite062009
nucleic acid binding	1.75861394475305	bayes_pls_golite062009
potassium channel activity	1.68725597823541	bayes_pls_golite062009
binding	1.64221234725269	bayes_pls_golite062009
transcription factor activity	1.62603723026304	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
phosphonate transmembrane transporter activity	1.40269234722336	bayes_pls_golite062009
peptide-transporting ATPase activity	1.37783759788533	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
sterol-transporting ATPase activity	1.30536878174919	bayes_pls_golite062009
glycoprotein transporter activity	1.30536878174919	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
peptide transporter activity	1.19353064661766	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	1.1220946941463	bayes_pls_golite062009
lipid transporter activity	1.10957173853622	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
sulfur amino acid transmembrane transporter activity	0.993585129677597	bayes_pls_golite062009
signal transducer activity	0.952448314982579	bayes_pls_golite062009
molecular transducer activity	0.952448314982579	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
motor activity	0.87979065815418	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
phospholipid transporter activity	0.755445322666929	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
transition metal ion binding	0.565091767161677	bayes_pls_golite062009
protein transporter activity	0.498432226280822	bayes_pls_golite062009
L-aspartate transmembrane transporter activity	0.483217496906356	bayes_pls_golite062009
apolipoprotein receptor activity	0.310540417068989	bayes_pls_golite062009
syntaxin-13 binding	0.310540417068989	bayes_pls_golite062009
apolipoprotein A-I binding	0.310540417068989	bayes_pls_golite062009
apolipoprotein A-I receptor activity	0.310540417068989	bayes_pls_golite062009
kinase activity	0.300431561463583	bayes_pls_golite062009
methionine transmembrane transporter activity	0.285898373513525	bayes_pls_golite062009
D-methionine transmembrane transporter activity	0.285898373513525	bayes_pls_golite062009
receptor activity	0.277332279568238	bayes_pls_golite062009
transmembrane receptor activity	0.243026482777117	bayes_pls_golite062009
neutral amino acid transmembrane transporter activity	0.227570438294493	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.219473333671469	bayes_pls_golite062009
protein kinase activity	0.194459978373898	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0689844878028699	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
transcription activator activity	0.0291047953833683	bayes_pls_golite062009

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Protein Overview: w-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: