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Protein Overview: Hmt-1-PA

General Information:
Name(s) found: Hmt-1-PA / FBpp0082642 [FlyBase]
Description(s) found:
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  • gi|7300071|gb|AAF55241.1| CG4225 [Drosophila melanogaster] [NCBI NR]
  • gi|21357907|ref|NP_650503.1| CG4225 [Drosophila melanogaster] [NCBI NR]
  • gi|19527665|gb|AAL89947.1| SD08058p [Drosophila melanogaster] [NCBI NR]
  • gi|189909196|gb|ACE60575.1| heavy metal tolerance factor 1 [Drosophila melanogaster] [NCBI NR]
  • The gene Heavy metal tolerance factor 1 is referred to in FlyBase by the symbol Dmel\Hmt-1 (CG4225, FBgn0038376). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11679590..11683194. It has the cytological map location 89A6. Based on sequence similarity, it is predicted to have molecular function</span>: ATPase activity, coupled to transmembrane movement of substances; transporter activity; heme transporter activity. There is experimental evidence that it is involved in the biological process</span>: response to cadmium ion. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG4225-PA translation from_gene[CG4225 CG4225 FBgn0038376] seq_release:3 mol_weight=97887 cds_boundaries:(3R:11,679,839..11,682,677[-]) aa_length:866 transcript_info:[CG4225-RA seq_release:3] gene_info:[gene symbol:CG4225 FBgn0038376 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VF20) CG4225 protein (SD08058p) [DrosMelano7227.FASTAC.txt]
  • (AE003710) CG4225 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG4225-PA [Drosophila melanogaster]gi|19527665|gb|AAL89947.1| SD08058p [Drosophila melanogaster]gi|21357907|ref|NP_650503.1| CG4225-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(11679818..11681187,11681251..11681655,11681719..11682044,11682105..11682304,11682360..11682659); ID=FBpp0082642; name=CG4225-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB [fly-100309-contam.fasta]
  • SD08058p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG4225-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(11679818..11681187,11681251..11681655,11681719..11682044,11682105..11682304,11682360..11682659); ID=FBpp0082642; name=CG4225-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB_protein:AAF55241.1,REFSEQ:NP_650503,GB_protein:AAF55241; MD5=c78b2c8a17bcd2f10b6da092cfe33f98; length=866; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(11679818..11681187,11681251..11681655,11681719..11682044,11682105..11682304,11682360..11682659); ID=FBpp0082642; name=Hmt-1-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB_protein:AAF55241.1,REFSEQ:NP_650503,GB_protein:AAF55241; MD5=c78b2c8a17bcd2f10b6da092cfe33f98; length=866; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Heavy metal tolerance factor 1 OS=Drosophila melanogaster GN=Hmt-1 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(11679818..11681187,11681251..11681655,11681719..11682044,11682105..11682304,11682360..11682659); ID=FBpp0082642; name=Hmt-1-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB_protein:AAF55241.1,REFSEQ:NP_650503,GB_protein:AAF55241,FlyMine:FBpp0082642,modMine:FBpp0082642; MD5=c78b2c8a17bcd2f10b6da092cfe33f98; length=866; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Heavy metal tolerance factor 1 OS=Drosophila melanogaster GN=Hmt-1 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:complement(join(15856638..15856937,15856383..15856582,15855997..15856322,15855529..15855933,15854096..15855465)); ID=FBpp0082642; name=Hmt-1-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB_protein:AAF55241.1,REFSEQ:NP_650503,GB_protein:AAF55241,FlyMine:FBpp0082642,modMine:FBpp0082642; MD5=c78b2c8a17bcd2f10b6da092cfe33f98; length=866; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(15856638..15856937,15856383..15856582,15855997..15856322,15855529..15855933,15854096..15855465)); ID=FBpp0082642; name=Hmt-1-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB_protein:AAF55241.1,REFSEQ:NP_650503,GB_protein:AAF55241,FlyMine:FBpp0082642,modMine:FBpp0082642; MD5=c78b2c8a17bcd2f10b6da092cfe33f98; length=866; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082642 type=protein; loc=3R:complement(join(15856638..15856937,15856383..15856582,15855997..15856322,15855529..15855933,15854096..15855465)); ID=FBpp0082642; name=Hmt-1-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB_protein:AAF55241.1,REFSEQ:NP_650503,GB_protein:AAF55241,FlyMine:FBpp0082642,modMine:FBpp0082642; MD5=c78b2c8a17bcd2f10b6da092cfe33f98; length=866; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(15856638..15856937,15856383..15856582,15855997..15856322,15855529..15855933,15854096..15855465)); ID=FBpp0082642; name=Hmt-1-PA; parent=FBgn0038376,FBtr0083188; dbxref=FlyBase:FBpp0082642,FlyBase_Annotation_IDs:CG4225-PA,GB_protein:AAF55241.1,REFSEQ:NP_650503,GB_protein:AAF55241,UniProt/TrEMBL:Q9VF20,FlyMine:FBpp0082642,modMine:FBpp0082642; MD5=c78b2c8a17bcd2f10b6da092cfe33f98; length=866; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 866 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDA]
    ATP-binding cassette (ABC) transporter complex [ISS]
    mitochondrial inner membrane [ISS]
    Biological Process: [NOT]cadmium ion transmembrane transport [IGI]
    response to cadmium ion [IGI]
    heme transport [ISS]
    Molecular Function: ATP binding [IEA]
    ATPase activity, coupled to transmembrane movement of substances [ISS]
    heme transporter activity [ISS]
    [NOT]cadmium ion transmembrane transporter activity [IGI]
    transporter activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYCPPNVTL SEVWTQHGIS HCFMDTVGPA VYGGFLLLFG SIQLLMYRKY ATRITDPTQI  60
   61 SKSRLFAMQL FLLLLLPVLA LLRFLMNARI YPDSAVYGYM IFSTCVVCFS YPFSICLILK 120
  121 ERYYQLPSMP TRGHGLVLLL FWTLAFINES LAFINLRHED WWFHLKTNKD QIEMGLFVTR 180
  181 FLCSLLIFVL GLKAPGIMAP YNPHQRLDND TANESQGNVQ TGSAFRNGWR KLRTVFPYLW 240
  241 PKKNIALQIA VIVCIILLLA GRVIKLFLPI YRKKLVDSLT IAPIVFRWDF VLIYVALSFL 300
  301 QGGGTGSMGL FNNLRTFLWI RVQQYTTREI EIELFRHLHQ LSLRWHLQRK TGEVLRVMDR 360
  361 GTDSINNLLN YIVFSIAPTI LDLLVAVAYF VYAFNWWFGL IVFLTMFLYI ASTIAITEWR 420
  421 TKYQRRMNLA DNEQRARSVD SLLNFETVKY YGAEHYEVDC YREAILKYQK EEFLSMLTLN 480
  481 MLNTAQNIIL CLGLLAGSLL CVYLVVHHQT LTVGDFVLFS TYLMELYMPL NWFGTYYRAI 540
  541 QKNFVDMENM FDLLKEEEEI VDAPGCSPLL TAGGGIEFSN VTFGYSPEKI VLRNVSFTVP 600
  601 AGKTVAIVGP SGAGKSTIMR LLFRFYDVQT GAILIDGQNI KLVQQQSLRK AIGVVPQDTV 660
  661 LFNNTIFYNI EYAKLGASDE AVYEAARAAD IHERILGFPE KYETKVGERG LRLSGGEKQR 720
  721 VAIARTLLKA PIIVLLDEAT SALDTHTERN IQAALARVCA NRTTIIVAHR LSTIIHADEI 780
  781 LVLQQGSIAE RGRHEELVLR EDGIYADMWQ QQLKNLDAEQ SGGSDNGDAS AESGSEKRRA 840
  841 GGAGGPSGTG TGGAHFRAGH AHGGAR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] deduced N/A No confident structure predictions are available.
    2 View Details [227..800] PSI-BLAST 149.0 No description for 2hydA was found.
    3 View Details [801..866] PSI-BLAST 62.0 Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • lipid transporter activity
    		•  7.47642599298853 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • heme transporter activity
    		•  4.82479229680991 bayes_pls_golite062009
  • peptide transporter activity
    		•  4.7442815698413 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  4.71935767060308 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  4.63590351019108 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • cofactor transporter activity
    		•  4.34709589308604 bayes_pls_golite062009
  • oligopeptide-transporting ATPase activity
    		•  4.09365342567844 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • phosphate transmembrane-transporting ATPase activity
    		•  3.20894563245332 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.19399273923292 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  3.16975154423199 bayes_pls_golite062009
  • hydrolase activity
    		•  3.14498892233323 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.13913638619234 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • ATP binding
    		•  3.01346604299372 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.00745742755195 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.96271391116269 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.9271291809464 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.91131545957759 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  2.88795687640992 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.70262534541085 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.70178191749524 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.6583477492092 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.63419811368692 bayes_pls_golite062009
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
  • sterol transporter activity
    		•  2.48473697371886 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  2.15147988861177 bayes_pls_golite062009
  • oligopeptide transporter activity
    		•  2.05580564974083 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • organic anion transmembrane transporter activity
    		•  1.76999970080179 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • binding
    		•  1.64266915208623 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • phosphonate transmembrane transporter activity
    		•  1.40269234722336 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • molybdate ion transmembrane transporter activity
    		•  1.28313088935613 bayes_pls_golite062009
  • molybdate transmembrane-transporting ATPase activity
    		•  1.28313088935613 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • potassium channel activity
    		•  1.20877745413881 bayes_pls_golite062009
  • sulfate transmembrane-transporting ATPase activity
    		•  1.1220946941463 bayes_pls_golite062009
  • dipeptide transporter activity
    		•  1.01130176523309 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.94708387424268 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.93133090558732 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.91827876091109 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  0.798934081014025 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • helicase activity
    		•  0.73689027003638 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.72833102894594 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.72833102894594 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  0.644421039250979 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.640772201693186 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.63468044350616 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.62832939629645 bayes_pls_golite062009
  • GTP binding
    		•  0.621689261700018 bayes_pls_golite062009
  • vitamin transporter activity
    		•  0.477646469354653 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • catalytic activity
    		•  0.368034275052766 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  0.219473333671469 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.20866768220789 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.144904409289829 bayes_pls_golite062009
  • sulfate transmembrane transporter activity
    		•  0.104477131120205 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • signal transducer activity
    		•  0.070999348597689 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.070999348597689 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.050232896280066 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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