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Protein Overview: CG8908-PB

General Information:
Name(s) found: CG8908-PB / FBpp0085587 [FlyBase]
Description(s) found:
Found 12 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG8908 (CG8908, FBgn0034493). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16152437..16158290. It has the cytological map location 56F11. Based on sequence similarity, it is predicted to have molecular function</span>: ATPase activity, coupled to transmembrane movement of substances; transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transport. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1665 amino acids

    Gene Ontology:
    Cellular Component: ATP-binding cassette (ABC) transporter complex [ISS]
    Biological Process: transport [ISS]
    Molecular Function: ATP binding [IEA]
    ATPase activity, coupled to transmembrane movement of substances [ISS]
    transporter activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGESPVKT QSSICLLWLV ICKTARFQFS NTLTSVIIIV GPIVVFLVYA ATALFREPQE  60
   61 ETSVKYPPVN ITTKVPYIYY SPENLVLAAV IEDVVHDLKA VGSKAFASAS ELNKALIGKD 120
  121 TYGYVGIEFD DSFSDINELP INVTVGLRFP LHLRKNPKMV WDNTSILKHS KMDVDYYQVE 180
  181 GFLVVQAKLS EALIRAKNEA VVLPEVILQH YPDVAEVDRL DNRVALGGVL FLPVTISAAY 240
  241 LAQMIVMERR DHLRDMLELM GVRAWIYWLS WFLVAFLLLS IPTVFMVLLL KWRYFSLSDS 300
  301 SLVLFFLLVY NLEVLTSAFM ISSFFSDTVG VQVAIVIVHL IGCLPWRLLL MGYVPTLPRT 360
  361 IFVCLFLNSS LAMGLQQFIK SENLRLGLHW TYLFERTDWD EFVHLGPILL FMLFGCLLRI 420
  421 LVLAYMEQLR SYQNRKWYFP VQPSFWCRWN RRPRSDDFDV EGQETGIRGH PLIVRARNIE 480
  481 KVFNEWIAVK DLNLNFYQDE ITVFLGHNDS GKSTILMLLA GFLRPSAGEI TINGYDLATN 540
  541 QRKARQSMCI CPQPNVLFEK VNARWHLQFY CRLKGLNRQE ASAETDKYLE IGRLQDFANT 600
  601 KVKNLPSGIK RMLMLCCNLC GNSKILLLDE PGTSMDPAMR SNMWDLLRRE RKGRCIIMAT 660
  661 HNMNEAEVVA DQIVVLCDAQ VIGYGTTGFL TQIAGTGSSY LLICTKMDTC IVAEVTNFLQ 720
  721 IRFPDIKLHN EFSIYVTYEL PTKYVQQYAA LFLELEEALG ELNLAEISVC APTLGSVFLQ 780
  781 MGEEMRQSWN RISSFDLLSS PSPMLSLLNL LPTFEVREDD GRVKCCNQWR AIVEKKRLFT 840
  841 LRHQKFYCMI IATPIIICLL IISFSIFIFL VDHHLSELLV TDLSIYPKAV FVIDSPAEGN 900
  901 RFERHYMANV IGQGGTVRST SGTPIDDYLL AEMESDQVKV QHTFLAGATF DSNANSIIAW 960
  961 SNNKLKHGSA LSMGLVYAAI GQELAKLDIR IVNKPYQDTV QQAVRGLIYA STIEFAVLVF1020
 1021 HYLVLGTAIF AVLPIVERRS KVQHQQFSSG MSRSTYWLSH LSWDYCFYIA MILPLIVVAG1080
 1081 ITIGSVLPVI VQLLAFGFSA ISFTYLLCLM SNDFGKMFSI ILYINMIGNY GFIVFLFGYC1140
 1141 KETLFPGVLA LFIHPKSPQT RYAVIESVLL VHPHYSLCCG MYEAIRMSTF SLKQLPYLIF1200
 1201 SGAAYLTIVV FAWVPRRLNY VFKLCLDQLC SSFMLTDYQL LFRSIRNEKI YPSYKDEDKE1260
 1261 VDKMRRRLAY LTTAHYAFFP LILKNLSKRY GSFVAVRSLT LDLNPFECVG LLGRNGSGKS1320
 1321 SIFRMIVGME SITVGSIHIK GYSLKTRPKD ASRHVGFCPR ELMLLSFMTG KDALRFCCLI1380
 1381 NGIRREYIKS LVASLAECFE LVPHMNKRIS TYSNGTKRKL MIAMGTLAPS LMCLDEPTAG1440
 1441 VDMHAKYEIW SILDGIRQGG RSILLTTHNL EECEFLCTNV GIMDHGSLLC YGSLSRLKHR1500
 1501 FNMGIFVKVK MGTRAEMDDE RDNWMQITMM PPNDSEMGST VGARRMMLAH LLRHHNPPVE1560
 1561 PVKKSRTSRA QPDTTNSELN MRKDYEALLQ ELEEVFKKDH PYSTVSEKYS YRGMITFCIP1620
 1621 RGQIKWSAIF EYMENLKDEM QILYYSVSHT TFQDVFMKFV RKQNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] MSA 1.181989 View MSA. No confident structure predictions are available.
    2 View Details [139..261] deduced N/A No confident structure predictions are available.
    3 View Details [262..707] PSI-BLAST 52.0 No description for 2hydA was found.
    4 View Details [708..880] PSI-BLAST 82.69897 Crystal structure of E. coli MalK in the nucleotide-free form
    5 View Details [881..966] deduced N/A No confident structure predictions are available.
    6 View Details [967..1276] deduced N/A No confident structure predictions are available.
    7 View Details [1277..1512] PSI-BLAST 60.0 Crystal structure of ABC transporter ATP-binding protein (TM0544) from Thermotoga maritima at 2.10 A resolution
    8 View Details [1513..1581] FFAS03 2.76 Crystal structure of ABC transporter ATP-binding protein (TM0544) from Thermotoga maritima at 2.10 A resolution
    9 View Details [1582..1665] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • lipopolysaccharide transmembrane transporter activity
    		•  5.90177503313326 bayes_pls_golite062009
  • lipopolysaccharide-transporting ATPase activity
    		•  5.90177503313326 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • polysaccharide transmembrane transporter activity
    		•  5.26442752745523 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • heme transporter activity
    		•  4.82479229680991 bayes_pls_golite062009
  • peptide transporter activity
    		•  4.7442815698413 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  4.71935767060308 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  4.63590351019108 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  4.35344629015015 bayes_pls_golite062009
  • oligopeptide-transporting ATPase activity
    		•  4.09365342567844 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • ATP binding
    		•  3.62300973398915 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  3.56796420118589 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  3.50845581803587 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • phosphate transmembrane-transporting ATPase activity
    		•  3.20894563245332 bayes_pls_golite062009
  • hydrolase activity
    		•  3.14498892233323 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  3.14373643903738 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.13913638619234 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • ribonucleotide binding
    		•  3.09294049852753 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  3.09132855853944 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • purine nucleotide binding
    		•  3.03820055021242 bayes_pls_golite062009
  • nucleotide binding
    		•  3.0109684031543 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.00745742755195 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.9271291809464 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  2.88795687640992 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.63419811368692 bayes_pls_golite062009
  • cofactor transporter activity
    		•  2.41442360192472 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • oligopeptide transporter activity
    		•  2.05580564974083 bayes_pls_golite062009
  • molybdate ion transmembrane transporter activity
    		•  2.04724145339382 bayes_pls_golite062009
  • molybdate transmembrane-transporting ATPase activity
    		•  2.04724145339382 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • lipid transporter activity
    		•  1.74534601529986 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • sugar transmembrane transporter activity
    		•  1.57734504779864 bayes_pls_golite062009
  • binding
    		•  1.40652776383476 bayes_pls_golite062009
  • carbohydrate-transporting ATPase activity
    		•  1.37859980472197 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • carbohydrate-importing ATPase activity
    		•  1.27327946933978 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • carbohydrate transmembrane transporter activity
    		•  1.21226071573355 bayes_pls_golite062009
  • potassium channel activity
    		•  1.20877745413881 bayes_pls_golite062009
  • sulfate transmembrane-transporting ATPase activity
    		•  1.1220946941463 bayes_pls_golite062009
  • dipeptide transporter activity
    		•  1.01130176523309 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • signal transducer activity
    		•  0.952448314982579 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.952448314982579 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.50574216781413 bayes_pls_golite062009
  • protein transporter activity
    		•  0.498432226280822 bayes_pls_golite062009
  • L-aspartate transmembrane transporter activity
    		•  0.483217496906356 bayes_pls_golite062009
  • kinase activity
    		•  0.465336251595641 bayes_pls_golite062009
  • catalytic activity
    		•  0.368034275052766 bayes_pls_golite062009
  • glucoside transmembrane transporter activity
    		•  0.31429820040527 bayes_pls_golite062009
  • maltose transmembrane transporter activity
    		•  0.309333293394255 bayes_pls_golite062009
  • alpha-glucoside transmembrane transporter activity
    		•  0.309333293394255 bayes_pls_golite062009
  • disaccharide transmembrane transporter activity
    		•  0.309333293394255 bayes_pls_golite062009
  • oligosaccharide transmembrane transporter activity
    		•  0.304521826432814 bayes_pls_golite062009
  • oligosaccharide-transporting ATPase activity
    		•  0.304521826432814 bayes_pls_golite062009
  • maltose-transporting ATPase activity
    		•  0.304521826432814 bayes_pls_golite062009
  • receptor activity
    		•  0.277332279568238 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.243026482777117 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  0.219473333671469 bayes_pls_golite062009
  • protein kinase activity
    		•  0.194459978373898 bayes_pls_golite062009
  • protein binding
    		•  0.193768631623192 bayes_pls_golite062009
  • vitamin transporter activity
    		•  0.162731691286377 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
    4
    Term Confidence Notes
  • transporter activity
    		•  1.9862037182943 bayes_pls_golite062009
  • binding
    		•  1.20758936215663 bayes_pls_golite062009
  • molybdenum ion binding
    		•  0.67834986270228 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.377407674495807 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle