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Protein Overview: FUM1

General Information:
Name(s) found: FUM1 / YPL262W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 488 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: tricarboxylic acid cycle [TASLink to PubMed article]
    fumarate metabolic process [TASLink to PubMed article]
    Molecular Function: fumarate hydratase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRFTNCSCK TFVKSSYKLN IRRMNSSFRT ETDAFGEIHV PADKYWGAQT QRSFQNFKIG  60
   61 GARERMPLPL VHAFGVLKKS AAIVNESLGG LDPKISKAIQ QAADEVASGK LDDHFPLVVF 120
  121 QTGSGTQSNM NANEVISNRA IEILGGKIGS KQVHPNNHCN QSQSSNDTFP TVMHIAASLQ 180
  181 IQNELIPELT NLKNALEAKS KEFDHIVKIG RTHLQDATPL TLGQEFSGYV QQVENGIQRV 240
  241 AHSLKTLSFL AQGGTAVGTG LNTKPGFDVK IAEQISKETG LKFQTAPNKF EALAAHDAIV 300
  301 ECSGALNTLA CSLFKIAQDI RYLGSGPRCG YHELMLPENE PGSSIMPGKV NPTQNEALTQ 360
  361 VCVQVMGNNA AITFAGSQGQ FELNVFKPVM IANLLNSIRL ITDAAYSFRV HCVEGIKANE 420
  421 PRIHELLTKS LMLVTALNPK IGYDAASKVA KNAHKKGITL KESALELGVL TEKEFDEWVV 480
  481 PEHMLGPK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Ho Y, et al. (2002) ACS2 ARC1 CAR2 CPR1 DLD3 DUG1 ERG10 FUM1 ILV3 PRO1 RAD1 RAD10 RHO1 RNR2 SAH1 TDA1 TFP1 TIF1, TIF2 VPS33 WTM1
    View Details Qiu et al. (2008) ACO1 CIT1 CIT3 FUM1 ICL2 NDE1 NDI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD9 FUM1 1 Unpublished Fields Lab Data
    View Screen TAM41 FUM1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FUM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193]
    [232..314]
    [358..407]    		 PSI-BLAST 11000.0 Fumarase
    2 View Details [194..231]
    [315..357]
    [408..428]    		 PSI-BLAST 11000.0 Fumarase
    3 View Details [429..488] PSI-BLAST 11000.0 Fumarase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fumarate hydratase activity
    		•  4.22589182982073 bayes_pls_golite062009
  • catalytic activity
    		•  2.51282259572665 bayes_pls_golite062009
  • lyase activity
    		•  2.31268471569846 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  2.2046475419807 bayes_pls_golite062009
  • histidine ammonia-lyase activity
    		•  0.948129236753279 bayes_pls_golite062009
  • amidine-lyase activity
    		•  0.901614580251298 bayes_pls_golite062009
  • binding
    		•  0.854855116369286 bayes_pls_golite062009
  • argininosuccinate lyase activity
    		•  0.617974375213548 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.491229595527877 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle