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View Structure Prediction Details

Protein: FUM1
Organism: Saccharomyces cerevisiae
Length: 488 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUM1.

Description E-value Query
Range		 Subject
Range
FUMH_YEAST - Fumarate hydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUM1 P...
FUM1 - Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distri...
gi|151942540 - gi|151942540|gb|EDN60886.1| fumarase [Saccharomyces cerevisiae YJM789]
gi|190407704 - gi|190407704|gb|EDV10969.1| fumarase [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..488] [1..488]
gi|31580769 - gi|31580769|gb|AAP51177.1| fumarase [Ascaris suum]
 0.0 [22..488] [1..467]
gi|19528365 - gi|19528365|gb|AAL90297.1| LD46083p [Drosophila melanogaster]
 0.0 [20..488] [26..495]
fum-1 - fumarase status:Confirmed UniProt:O17214 protein_id:AAB70982.1
 0.0 [15..488] [32..501]
FUMH_DANRE - Fumarate hydratase, mitochondrial OS=Danio rerio GN=fh PE=2 SV=1
 0.0 [16..488] [37..509]
FUM2_ARATH - Fumarate hydratase 2, chloroplastic OS=Arabidopsis thaliana GN=FUM2 PE=2 SV=1
 0.0 [5..487] [16..497]

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Predicted Domain #1
Region A:
Residues: [1-193] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRFTNCSCK TFVKSSYKLN IRRMNSSFRT ETDAFGEIHV PADKYWGAQT QRSFQNFKIG  60
   61 GARERMPLPL VHAFGVLKKS AAIVNESLGG LDPKISKAIQ QAADEVASGK LDDHFPLVVF 120
  121 QTGSGTQSNM NANEVISNRA IEILGGKIGS KQVHPNNHCN QSQSSNDTFP TVMHIAASLQ 180
  181 IQNELIPELT NLK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [232-314] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVENGIQRVA HSLKTLSFLA QGGTAVGTGL NTKPGFDVKI AEQISKETGL KFQTAPNKFE  60
   61 ALAAHDAIVE CSGALNTLAC SLF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [358-407] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTQVCVQVMG NNAAITFAGS QGQFELNVFK PVMIANLLNS IRLITDAAYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1yfm__
Description: Fumarase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
fumarate hydratase activity 4.22589182982073 bayes_pls_golite062009
catalytic activity 2.51282259572665 bayes_pls_golite062009
lyase activity 2.31268471569846 bayes_pls_golite062009
carbon-nitrogen lyase activity 2.2046475419807 bayes_pls_golite062009
histidine ammonia-lyase activity 0.948129236753279 bayes_pls_golite062009
amidine-lyase activity 0.901614580251298 bayes_pls_golite062009
binding 0.854855116369286 bayes_pls_golite062009
argininosuccinate lyase activity 0.617974375213548 bayes_pls_golite062009
ammonia-lyase activity 0.491229595527877 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [194-231] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NALEAKSKEF DHIVKIGRTH LQDATPLTLG QEFSGYVQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [315-357] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIAQDIRYLG SGPRCGYHEL MLPENEPGSS IMPGKVNPTQ NEA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [408-428] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRVHCVEGIK ANEPRIHELL T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1yfm__
Description: Fumarase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [429-488] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSLMLVTALN PKIGYDAASK VAKNAHKKGI TLKESALELG VLTEKEFDEW VVPEHMLGPK  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1yfm__
Description: Fumarase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle