Protein Overview: RDS2

General Information:
Name(s) found:	RDS2 / YPL133C [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Zinc cluster transcriptional activator involved in conferring resistance to ketoconazole [SGD]
Organism:	Saccharomyces cerevisiae
Length:	446 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	response to xenobiotic stimulus [IMP]
Molecular Function:	transcription factor activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANSGVKRA SKAFKTCLFC KRSHVVCDKQ RPCSRCVKRD IAHLCREDDI AVPNEMPSQH  60
   61 ESSPNDNNIQ GKYANKAHTG IPSDYQNEPV NKSGSTYGEE LSPKLDSSLV NDTTSLLLPQ 120
  121 QPVFVSENVG SEFSSLNEFL SMLENPLLTQ TSLSSSSASN VHLENGSQTT QSPLEYQNDN 180
  181 RRDEIGVARQ ENRSPTIMSG SSNSISKGDK QDQEKEESRI LANANENSAP TPKEQFFLTA 240
  241 ADPSTEMTPE HRLKLVINAK LEAGLLKPYN YAKGYARLQD YMDKYMNQSS KQRILKPLST 300
  301 IRPAFRTIAR SLKDVDLVLV EESFERMLLS YDRVFTSMSM PACLCRRTGE IYRANKEFAS 360
  361 LVDCTVDDLR DGKLAIYELM TEESAVNFWE KYGSIAFDKG QKAVLTSCSL RTKDGIRKRP 420
  421 CCFSFTIRRD RYNIPICIVG NFIPLS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPP382	RDS2	2	Hazbun TR, et al. (2003)
View Screen	ERT1	RDS2	2	Unpublished Fields Lab Data
View Screen	PSE1	RDS2	2	Uetz P, et al. (2000)
View Screen	GBP2	RDS2	1	Unpublished Fields Lab Data
View Screen	MPC54	RDS2	1	Unpublished Fields Lab Data
View Screen	YPT31	RDS2	1	Unpublished Fields Lab Data
View Screen	RGD2	RDS2	1	Unpublished Fields Lab Data
View Screen	PAU12	RDS2	1	Unpublished Fields Lab Data
View Screen	IRE1	RDS2	1	Unpublished Fields Lab Data
View Screen	YCK1	RDS2	1	Unpublished Fields Lab Data
View Screen	YJU2	RDS2	1	Unpublished Fields Lab Data
View Screen	RPT1	RDS2	1	Unpublished Fields Lab Data
View Screen	TPK3	RDS2	1	Unpublished Fields Lab Data
View Screen	PEX1	RDS2	1	Unpublished Fields Lab Data
View Screen	LOS1	RDS2	1	Unpublished Fields Lab Data
View Screen	YPT6	RDS2	1	Unpublished Fields Lab Data
View Screen	NSE5	RDS2	1	Hazbun TR, et al. (2003)
View Screen	TEM1	RDS2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RDS2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..55]	PSI-BLAST	30.457575	Hap1 (Cyp1)
2	View Details	[56..197]	MSA	3.276997	View MSA. Confident ab initio structure predictions are available.
3	View Details	[198..446]	deduced	N/A	No confident structure predictions are available.
4	View Details	[269..446]	FFAS03	1.77	Photoactive yellow protein, PYP

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transcription regulator activity	4.03513015433673	bayes_pls_golite062009
DNA binding	3.83205668382335	bayes_pls_golite062009
nucleic acid binding	3.67300498747674	bayes_pls_golite062009
binding	2.91929847152301	bayes_pls_golite062009
transcription factor activity	2.68631095170929	bayes_pls_golite062009
sequence-specific DNA binding	2.68175655600795	bayes_pls_golite062009
transcription activator activity	1.89281746291341	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.69668907232116	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63882951698535	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
transcription regulator activity	3.7467368529492	bayes_pls_golite062009
DNA binding	3.40921169912637	bayes_pls_golite062009
nucleic acid binding	3.24167117005747	bayes_pls_golite062009
binding	3.0194696248926	bayes_pls_golite062009
transcription activator activity	2.83653821066646	bayes_pls_golite062009
transcription factor activity	2.82130392807705	bayes_pls_golite062009
protein binding	2.65718874796652	bayes_pls_golite062009
sequence-specific DNA binding	2.35155212316148	bayes_pls_golite062009
transcription factor binding	2.0886105134698	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.80286525617588	bayes_pls_golite062009
protein heterodimerization activity	1.6684022582724	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	1.34975446517091	bayes_pls_golite062009
protein dimerization activity	1.32117360800315	bayes_pls_golite062009
transcription cofactor activity	0.894812998943802	bayes_pls_golite062009
transcription coactivator activity	0.718695359890957	bayes_pls_golite062009
histone acetyltransferase binding	0.398021385666875	bayes_pls_golite062009
receptor binding	0.19484761881511	bayes_pls_golite062009
nuclear hormone receptor binding	0.180141371842267	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2