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Protein Overview: RTS1

General Information:
Name(s) found: RTS1 / YOR014W [SGD]
Description(s) found:
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  • gi|829124|emb|CAA60763.1| multicopy suppressor of ROX3 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6324588|ref|NP_014657.1| B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A; Rts1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1710806|sp|P38903.2|2A5D_YEAST RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; AltName: Full=PP2A, B subunit, B' delta isoform; AltName: Full=Protein RTS1; AltName: Full=Protein SCS1 [NCBI NR]
  • gi|1420113|emb|CAA99203.1| RTS1 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S54620 RTS1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Saccharomyces cerevisiae GN=RTS1 PE=1 SV=2 [Swiss-Prot]
  • RTS1 Potential regulatory subunit of protein phosphatase 2A [mips]
  • B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A [SGD]
  • (P38903) Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform (PP2A, B subunit, B' delta isoform) (RTS1 protein) (SCS1 protein) [4932.FASTACCERV.txt]
  • Chr XV from 357673-359946 [hmr_yeast5_DM3-1_pombe.fasta]
  • RTS1, Chr XV from 357673-359946 [yeast_orfs2]
  • RTS1 SGDID:S0005540, Chr XV from 357673-359946, Verified ORF [yeastflysequest.fasta]
  • B-type regulatory subunit of protein phosphatase 2A (PP2A) [Saccharomyces cerevisiae]gi|829124|emb|CAA60763.1| multicopy suppressor of ROX3 [Saccharomyces cerevisiae]gi|1420113|emb|CAA99203.1| RTS1 [Saccharomyces cerevisiae]gi|1710806|sp|P38903|2A5D_YE [nrdb_11152004_Chlamydomonas]
  • RTS1 SGDID:S000005540, Chr XV from 357673-359946, Verified ORF, "B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • RTS1 SGDID:S000005540, Chr XV from 357674-359947, Verified ORF, "B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A" [yeast-contam.fasta]
  • multicopy suppressor of ROX3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A; Rts1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (Protein RTS1) (Protein SCS1) [nr-271106-contam.fasta]
  • RTS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTS1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RTS1 SGDID:S000005540, Chr XV from 357674-359947, Genome Release 64-1-1, Verified ORF, "B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in absence of Cdc55p; homolog of the mammalian B' subunit of PP2A" [yeast-030211-contam.fasta]
  • RTS1 SGDID:S000005540, Chr XV from 357674-359947, Genome Release 64-2-1, Verified ORF, "B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A" [20141208_orf_trans.fasta]
  • TR7390|c0_g1_i1|g.5427 ORF TR7390|c0_g1_i1|g.5427 TR7390|c0_g1_i1|m.5427 type:complete len:758 (+) TR7390|c0_g1_i1:253-2526(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YOR014W SGDID:S000005540, Chr XV from 357674-359947, Genome Release 64-1-1, Verified ORF, "B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in absence of Cdc55p; homolog of the mammalian B' subunit of PP2A" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_2222|g.1503 ORF ID=asmbl_2222|g.1503 ID=asmbl_2222|m.1503 type:complete len:758 (+) ID=asmbl_2222:252-2525(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 757 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    condensed nuclear chromosome, centromeric region [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    protein phosphatase type 2A complex [TASLink to PubMed article]
    Biological Process: protein amino acid dephosphorylation [TASLink to PubMed article]
    meiotic sister chromatid cohesion, centromeric [IMPLink to PubMed article]
    translation [ISSLink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [IPI]
    protein phosphatase type 2A regulator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRGFKQRLI KKTTGSSSSS SSKKKDKEKE KEKSSTTSST SKKPASASSS SHGTTHSSAS  60
   61 STGSKSTTEK GKQSGSVPSQ GKHHSSSTSK TKTATTPSSS SSSSRSSSVS RSGSSSTKKT 120
  121 SSRKGQEQSK QSQQPSQSQK QGSSSSSAAI MNPTPVLTVT KDDKSTSGED HAHPTLLGAV 180
  181 SAVPSSPISN ASGTAVSSDV ENGNSNNNNM NINTSNTQDA NHASSQSIDI PRSSHSFERL 240
  241 PTPTKLNPDT DLELIKTPQR HSSSRFEPSR YTPLTKLPNF NEVSPEERIP LFIAKVDQCN 300
  301 TMFDFNDPSF DIQGKEIKRS TLDELIEFLV TNRFTYTNEM YAHVVNMFKI NLFRPIPPPV 360
  361 NPVGDIYDPD EDEPVNELAW PHMQAVYEFF LRFVESPDFN HQIAKQYIDQ DFILKLLELF 420
  421 DSEDIRERDC LKTTLHRIYG KFLSLRSFIR RSMNNIFLQF IYETEKFNGV AELLEILGSI 480
  481 INGFALPLKE EHKVFLVRIL IPLHKVRCLS LYHPQLAYCI VQFLEKDPLL TEEVVMGLLR 540
  541 YWPKINSTKE IMFLNEIEDI FEVIEPLEFI KVEVPLFVQL AKCISSPHFQ VAEKVLSYWN 600
  601 NEYFLNLCIE NAEVILPIIF PALYELTSQL ELDTANGEDS ISDPYMLVEQ AINSGSWNRA 660
  661 IHAMAFKALK IFLETNPVLY ENCNALYLSS VKETQQRKVQ REENWSKLEE YVKNLRINND 720
  721 KDQYTIKNPE LRNSFNTASE NNTLNEENEN DCDSEIQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC55 PPH21 PPH22 RRD2 RTS1 TPD3 ZDS1
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) CDC55 GPG1 HEM15 HTA2 MKT1 PPE1 PPH21 PPH22 RPA135 RPB11 RPC40 RTS1 RTS3 RVB1 TAP42 TPD3
    View Details Qiu et al. (2008) CDC14 CDC55 GIP2 GLC7 PPH21 PPH22 RTS1 RTS3 TPD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RTS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..282] ORFEUS 12.27 Fibrinogen
    2 View Details [283..374] MSA 1.320983 View MSA. No confident structure predictions are available.
    3 View Details [375..469] ORFEUS 8.75 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    4 View Details [470..757] ORFEUS 8.75 Constant regulatory domain of protein phosphatase 2a, pr65alpha

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.41566231556356 bayes_pls_golite062009
  • phosphatase activity
    		•  6.2815295903206 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.23975872771765 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.04343158483355 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.13001603767079 bayes_pls_golite062009
  • protein phosphatase type 2A regulator activity
    		•  4.9046120881035 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  2.6399267580941 bayes_pls_golite062009
  • binding
    		•  2.6374633159018 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  2.60055057218296 bayes_pls_golite062009
  • hydrolase activity
    		•  1.97016752220053 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.698613639309592 bayes_pls_golite062009
  • kinase activity
    		•  0.60321289927821 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.590594379094637 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.549076739943715 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.500341303844313 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.410980330975135 bayes_pls_golite062009
  • transferase activity
    		•  0.23030640245878 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  0.0443887387331605 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0343779350724151 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0332743336452223 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.0268373969988844 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.00234756529236324 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle