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Protein Overview: TCB2

General Information:
Name(s) found: TCB2 / YNL087W [SGD]
Description(s) found:
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  • gi|887624|emb|CAA61423.1| ORF N2250 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6324242|ref|NP_014312.1| Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the [NCBI NR]
  • pir||S57535 probable membrane protein YNL087w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1353095|sp|P48231.1|TCB2_YEAST RecName: Full=Tricalbin-2 [NCBI NR]
  • gi|1301987|emb|CAA95963.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P48231) Hypothetical 132.5 kDa protein in TOP2-MKT1 intergenic region [Swiss-Prot]
  • Tricalbin-2 OS=Saccharomyces cerevisiae GN=TCB2 PE=1 SV=1 [Swiss-Prot]
  • TCB2 Protein localized to membranes, bud-enriched [mips]
  • Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud [SGD]
  • YNL087W, Chr XIV from 462408-465944 [yeast_orfs2]
  • Chr XIV from 462408-465944 [yeastorf3.fasta]
  • TCB2 SGDID:S0005031, Chr XIV from 462411-465947, Uncharacterized ORF [yeastflysequest.fasta]
  • TCB2 SGDID:S0005031, Chr XIV from 462411-465947, Verified ORF [10112005cervSGD.fasta]
  • Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud via the mRNA transport [nrdb_11152004_Chlamydomonas]
  • TCB2 SGDID:S000005031, Chr XIV from 462413-465949, Verified ORF, "Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid bi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ORF N2250 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud via the mRNA transport [nr-271106-contam.fasta]
  • Tricalbin-2 [nr-271106-contam.fasta]
  • TCB2 SGDID:S000005031, Chr XIV from 462413-465949, Verified ORF, "Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud" [yeast-bovrabprots.fasta]
  • TCB2 SGDID:S000005031, Chr XIV from 462413-465949, Verified ORF, "Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud via the mRNA transport system involving She2p" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Tricalbin-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TCB2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TCB2 SGDID:S000005031, Chr XIV from 462411-465947, Genome Release 64-1-1, Verified ORF, "Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud" [yeast-030211-contam.fasta]
  • TCB2 SGDID:S000005031, Chr XIV from 462411-465947, Genome Release 64-2-1, Verified ORF, "ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to bud; TCB2 has a paralog, TCB1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL087W SGDID:S000005031, Chr XIV from 462411-465947, Genome Release 64-1-1, Verified ORF, "Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1178 amino acids

    Gene Ontology:
    Cellular Component: cellular bud [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPNSSKTRT DQISSMPGIN EATKVESKNV VKDAVPIKSE VETNGTSIVR EKQDPSYVGW  60
   61 KQVGGWEEKD ELTSEDLLVD VNKDTFLGNL LPDKFYGDWY HEVAILIIAG LCSFVLGYFK 120
  121 FSLASVLIVM LTTGMLYRTS SKKYRESLRD LAQKEQTVEK ITSDYESVEW LNTFLDKYWP 180
  181 IIEPSVSQQI VDGTNTALSE NVAIPKFIKA IWLDQFTLGV KPPRIDAIKT FQNTKSDVVV 240
  241 MDVCLSFTPH DMSDLDAKQC RNYVNSNVVL KAKIFGMDIP VSVADIFFQV FVRFRFQLMT 300
  301 TLPLVETINI QLLEVPEVDF ISRLLGNSVF NWEILAIPGL MRLIQKMAFK YLSPVLLPPF 360
  361 SLQLNIPQLL SKTGLPIGVL EIKVKNAHGL RKLVGMIKKT VDPYLTFELS GKIVGKTKVF 420
  421 KNSANPVWNE SIYILLQSFT DPLTIAVYDK RETLSDKKMG TVIFNLNKLH ANHYHKNEKV 480
  481 HFLRNSKPVG ELTFDLRFFP TIEPKKLLNG DEEPLPDMNT GITKITIREL KGLDELSDKK 540
  541 FVFAELYVNA ELVMTTKKEK RTAHLKWNSD YYSVVTDRRK TICRFVLKDQ SGKVISSSVQ 600
  601 PLNHLIDRTE VNKEWIPLRN GKGELKVTTY WRPVDIDLGL KSVGYTTPIG MLRVFINKAE 660
  661 NLRNPDSLGK ISPYAKVSVN GVARGRTNER IETLNPIWNQ SIYVSVTSPL QKVSIDCFGI 720
  721 DTNGDDHNLG SLNIQTQNIY HKDNDDKYTI FIDNAPRTGN LIGKKGVKGT VTYYLSFYPV 780
  781 VPVLSLEEAK EVDEINEKKD KLEKQKSTLD DKNISKEEKE RIKKEEFRLT EKYDMYSYKM 840
  841 KLDLDELLQY NAGVLGVTVL GGELPQPGLY VQTFFDSCGY AAITSAKNAI RTIKTGWSGD 900
  901 FMIKELEWSV TTFRVTKTKD ANKAENFICE VNIPTIELVR NCYYKPSVLN LIGKKSAKLL 960
  961 VQVSWFPVTA TELPQSDLIT NSGDLKITAK SAENLIGVNK NGYSDPYVEF FLNEKSTSPF1020
 1021 FKTAVQKKTL NPTWNESKTI EVSNRVNDYL TINVKDYEST NSNRSIGKAV VPLSTIDPES1080
 1081 DTTFNIPLVG PKGEDGGVLH LEFEFEPRYT TNVVKREAGL GNFATKGLGT GIKAGSTVFA1140
 1141 LGTNVVSTGL GTIDKVKAGV FGGKKSTTTG DKKSEEKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CKB1 TCB2 2 Unpublished Fields Lab Data
    View Screen MSA2 TCB2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TCB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..206] deduced N/A No confident structure predictions are available.
    2 View Details [207..362] PSI-BLAST 123.124002 Synaptogamin I
    3 View Details [363..488] PSI-BLAST 123.124002 Synaptogamin I
    4 View Details [489..622] ab initio 14.78 No description for 1bynA was found.
    5 View Details [623..781] PSI-BLAST 50.751666 Synaptogamin I
    6 View Details [782..922] deduced N/A No confident structure predictions are available.
    7 View Details [923..1119] PSI-BLAST 88.9794 STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD
    8 View Details [1120..1178] MSA 1.139995 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle