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Protein Overview: DCS1

General Information:
Name(s) found: DCS1 / YLR270W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytoplasmic mRNA processing body [IDALink to PubMed article]
    Biological Process: deadenylation-dependent decapping of nuclear-transcribed mRNA [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    m7G(5')pppN diphosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQLPTDFAS LIKRFQFVSV LDSNPQTKVM SLLGTIDNKD AIITAEKTHF LFDETVRRPS  60
   61 QDGRSTPVLY NCENEYSCIN GIQELKEITS NDIYYWGLSV IKQDMESNPT AKLNLIWPAT 120
  121 PIHIKKYEQQ NFHLVRETPE MYKRIVQPYI EEMCNNGRLK WVNNILYEGA ESERVVYKDF 180
  181 SEENKDDGFL ILPDMKWDGM NLDSLYLVAI VYRTDIKTIR DLRYSDRQWL INLNNKIRSI 240
  241 VPGCYNYAVH PDELRILVHY QPSYYHFHIH IVNIKHPGLG NSIAAGKAIL LEDIIEMLNY 300
  301 LGPEGYMNKT ITYAIGENHD LWKRGLEEEL TKQLERDGIP KIPKIVNGFK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DCS1 DCS2
    View Details Krogan NJ, et al. (2006) DCS1 DCS2 YPL245W
    View Details Ho Y, et al. (2002) AHP1 CDC39 DCS1 DCS2 DNM1 GDB1 RAD50 TSA2 UBP15 UBR1 VPS1 YAK1 YLR241W YPL247C
    View Details Qiu et al. (2008) DCP1 DCP2 DCS1 DCS2 DHH1 RPB4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DCS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] deduced N/A No confident structure predictions are available.
    2 View Details [158..350] ORFEUS 9.25 Protein kinase C inhibitor-1, PKCI-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • m7G(5')pppN diphosphatase activity
    		•  11.4290795741181 bayes_pls_golite062009
  • RNA binding
    		•  2.65561768780165 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.24536295645879 bayes_pls_golite062009
  • binding
    		•  1.12315862086587 bayes_pls_golite062009
  • hydrolase activity
    		•  0.927269748430359 bayes_pls_golite062009
  • catalytic activity
    		•  0.096119422680995 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle