YRC Public Data Repository - Protein Structure Prediction

Protein:	DCS1
Organism:	Saccharomyces cerevisiae
Length:	350 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCS1.

Description	E-value	Query Range	Subject Range
gi\|151941104 - gi\|151941104\|gb\|EDN59484.1\| conserved protein [Saccharomyces cerevisiae YJM789] DCPS_YEAST - m7GpppX diphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCS1 PE=1 SV=1 DCS1 - Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate... gi\|190405330 - gi\|190405330\|gb\|EDV08597.1\| hypothetical protein SCRG_04221 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..350]	[1..350]
DCPS - decapping enzyme, scavenger	0.0	[15..323]	[47..329]
nhm1 - m7G(5')pppN diphosphatase DCPS_SCHPO - m7GpppX diphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nhm1 PE=1 SV=1	0.0	[11..323]	[11..297]
DCPS_MOUSE - m7GpppX diphosphatase OS=Mus musculus GN=Dcps PE=1 SV=1	0.0	[15..320]	[46..325]
dcs-1 - status:Confirmed UniProt:Q9U2Y7 protein_id:CAB60481.1	2.0E-81	[16..323]	[27..303]
gi\|19069424, gi\|... - gi\|19074782\|ref\|NP_586288.1\| hypothetical protein ECU10_1710 [Encephalitozoon cuniculi GB-M1], gi\|19... gi\|19074782 - ref\|NP_586288.1\| hypothetical protein [Encephalitozoon cuniculi]	1.0E-61	[34..309]	[24..254]

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Predicted Domain #1

Region A:
Residues: [1-157]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQLPTDFAS LIKRFQFVSV LDSNPQTKVM SLLGTIDNKD AIITAEKTHF LFDETVRRPS  60
   61 QDGRSTPVLY NCENEYSCIN GIQELKEITS NDIYYWGLSV IKQDMESNPT AKLNLIWPAT 120
  121 PIHIKKYEQQ NFHLVRETPE MYKRIVQPYI EEMCNNG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
m7G(5')pppN diphosphatase activity	11.4290795741181	bayes_pls_golite062009
RNA binding	2.65561768780165	bayes_pls_golite062009
nucleic acid binding	1.24536295645879	bayes_pls_golite062009
binding	1.12315862086587	bayes_pls_golite062009
hydrolase activity	0.927269748430359	bayes_pls_golite062009
catalytic activity	0.096119422680995	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [158-350]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLKWVNNILY EGAESERVVY KDFSEENKDD GFLILPDMKW DGMNLDSLYL VAIVYRTDIK  60
   61 TIRDLRYSDR QWLINLNNKI RSIVPGCYNY AVHPDELRIL VHYQPSYYHF HIHIVNIKHP 120
  121 GLGNSIAAGK AILLEDIIEM LNYLGPEGYM NKTITYAIGE NHDLWKRGLE EELTKQLERD 180
  181 GIPKIPKIVN GFK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.25
Match:	1av5A
Description:	Protein kinase C inhibitor-1, PKCI-1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: