YRC Public Data Repository - Protein Structure Prediction

Protein:	DCS1
Organism:	Saccharomyces cerevisiae
Length:	350 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCS1.

Description	E-value	Query Range	Subject Range
gi\|151941104 - gi\|151941104\|gb\|EDN59484.1\| conserved protein [Saccharomyces cerevisiae YJM789] DCPS_YEAST - m7GpppX diphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCS1 PE=1 SV=1 DCS1 - Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate... gi\|190405330 - gi\|190405330\|gb\|EDV08597.1\| hypothetical protein SCRG_04221 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..350]	[1..350]
DCPS - decapping enzyme, scavenger	0.0	[15..323]	[47..329]
nhm1 - m7G(5')pppN diphosphatase DCPS_SCHPO - m7GpppX diphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nhm1 PE=1 SV=1	0.0	[11..323]	[11..297]
DCPS_MOUSE - m7GpppX diphosphatase OS=Mus musculus GN=Dcps PE=1 SV=1	0.0	[15..320]	[46..325]
dcs-1 - status:Confirmed UniProt:Q9U2Y7 protein_id:CAB60481.1	2.0E-81	[16..323]	[27..303]
gi\|19069424, gi\|... - gi\|19074782\|ref\|NP_586288.1\| hypothetical protein ECU10_1710 [Encephalitozoon cuniculi GB-M1], gi\|19... gi\|19074782 - ref\|NP_586288.1\| hypothetical protein [Encephalitozoon cuniculi]	1.0E-61	[34..309]	[24..254]

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Predicted Domain #1

Region A:
Residues: [1-157]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQLPTDFAS LIKRFQFVSV LDSNPQTKVM SLLGTIDNKD AIITAEKTHF LFDETVRRPS  60
   61 QDGRSTPVLY NCENEYSCIN GIQELKEITS NDIYYWGLSV IKQDMESNPT AKLNLIWPAT 120
  121 PIHIKKYEQQ NFHLVRETPE MYKRIVQPYI EEMCNNG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
m7G(5')pppN diphosphatase activity	11.4290795741181	bayes_pls_golite062009
RNA binding	2.65561768780165	bayes_pls_golite062009
nucleic acid binding	1.24536295645879	bayes_pls_golite062009
binding	1.12315862086587	bayes_pls_golite062009
hydrolase activity	0.927269748430359	bayes_pls_golite062009
catalytic activity	0.096119422680995	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [158-350]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLKWVNNILY EGAESERVVY KDFSEENKDD GFLILPDMKW DGMNLDSLYL VAIVYRTDIK  60
   61 TIRDLRYSDR QWLINLNNKI RSIVPGCYNY AVHPDELRIL VHYQPSYYHF HIHIVNIKHP 120
  121 GLGNSIAAGK AILLEDIIEM LNYLGPEGYM NKTITYAIGE NHDLWKRGLE EELTKQLERD 180
  181 GIPKIPKIVN GFK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.25
Match:	1av5A
Description:	Protein kinase C inhibitor-1, PKCI-1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: