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Protein Overview: MDL1

General Information:
Name(s) found: MDL1 / YLR188W [SGD]
Description(s) found:
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  • gi|6323217|ref|NP_013289.1| Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative [NCBI NR]
  • gi|577195|gb|AAB67455.1| Mdl1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1346512|sp|P33310.2|MDL1_YEAST RecName: Full=ATP-dependent permease MDL1, mitochondrial; AltName: Full=Multidrug resistance-like protein 1; AltName: Full=ABC transporter MDL1; Flags: Precursor [NCBI NR]
  • pir||S51433 MDL1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • ATP-dependent permease MDL1, mitochondrial OS=Saccharomyces cerevisiae GN=MDL1 PE=1 SV=2 [Swiss-Prot]
  • MDL1 Half-size ABC transporter, mitochondrial [mips]
  • Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress [SGD]
  • MDL1, Chr XII from 528302-530389 [yeast_orfs2]
  • Chr XII from 528302-530389 [yeastorf3.fasta]
  • (P33310) ATP-dependent permease MDL1 [4932.FASTACCERV.txt]
  • MDL1 SGDID:S0004178, Chr XII from 528302-530389, Verified ORF [yeastflysequest.fasta]
  • ATP-binding cassette (ABC) transporter family member [Saccharomyces cerevisiae]gi|1346512|sp|P33310|MDL1_YEAST ATP-dependent permease MDL1gi|577195|gb|AAB67455.1| Mdl1p [Saccharomyces cerevisiae]gi|1078101|pir||S51433 MDL1 protein - yeast (Saccharomyce [nrdb_11152004_Chlamydomonas]
  • MDL1 SGDID:S000004178, Chr XII from 528302-530389, Verified ORF, "Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the r [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MDL1 SGDID:S000004178, Chr XII from 528302-530389, Verified ORF, "Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulati [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Mdl1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ATP-dependent permease MDL1, mitochondrial precursor (ABC transporter MDL1) (Multidrug resistance-like protein 1) [nr-271106-contam.fasta]
  • Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress; Mdl1p [Sacch [nr-271106-contam.fasta]
  • MDL1 SGDID:S000004178, Chr XII from 528302-530389, Verified ORF, "Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress" [yeast-bovrabprots.fasta]
  • MDL1 SGDID:S000004178, Chr XII from 528302-530389, Verified ORF, "Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • ATP-dependent permease MDL1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDL1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MDL1 SGDID:S000004178, Chr XII from 528300-530387, Genome Release 64-1-1, Verified ORF, "Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress" [yeast-030211-contam.fasta]
  • MDL1 SGDID:S000004178, Chr XII from 528300-530387, Genome Release 64-2-1, Verified ORF, "Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress" [20141208_orf_trans.fasta]
  • YLR188W SGDID:S000004178, Chr XII from 528300-530387, Genome Release 64-1-1, Verified ORF, "Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 695 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: oligopeptide transport [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    ATPase activity, coupled to transmembrane movement of substances [IMPLink to PubMed article][ISSLink to PubMed article]
    peptide-transporting ATPase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVRMIRLCK GPKLLRSQFA SASALYSTKS LFKPPMYQKA EINLIIPHRK HFLLRSIRLQ  60
   61 SDIAQGKKST KPTLKLSNAN SKSSGFKDIK RLFVLSKPES KYIGLALLLI LISSSVSMAV 120
  121 PSVIGKLLDL ASESDGEDEE GSKSNKLYGF TKKQFFTALG AVFIIGAVAN ASRIIILKVT 180
  181 GERLVARLRT RTMKAALDQD ATFLDTNRVG DLISRLSSDA SIVAKSVTQN VSDGTRAIIQ 240
  241 GFVGFGMMSF LSWKLTCVMM ILAPPLGAMA LIYGRKIRNL SRQLQTSVGG LTKVAEEQLN 300
  301 ATRTIQAYGG EKNEVRRYAK EVRNVFHIGL KEAVTSGLFF GSTGLVGNTA MLSLLLVGTS 360
  361 MIQSGSMTVG ELSSFMMYAV YTGSSLFGLS SFYSELMKGA GAAARVFELN DRKPLIRPTI 420
  421 GKDPVSLAQK PIVFKNVSFT YPTRPKHQIF KDLNITIKPG EHVCAVGPSG SGKSTIASLL 480
  481 LRYYDVNSGS IEFGDEDIRN FNLRKYRRLI GYVQQEPLLF NGTILDNILY CIPPEIAEQD 540
  541 DRIRRAIGKA NCTKFLANFP DGLQTMVGAR GAQLSGGQKQ RIALARAFLL DPAVLILDEA 600
  601 TSALDSQSEE IVAKNLQRRV ERGFTTISIA HRLSTIKHST RVIVLGKHGS VVETGSFRDL 660
  661 IAIPNSELNA LLAEQQDEEG KGGVIDLDNS VAREV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #27 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps3-5 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MDL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A No confident structure predictions are available.
    2 View Details [79..195]
    [214..411]    		 PSI-BLAST 798.9794 MsbA
    3 View Details [196..213]
    [412..695]    		 PSI-BLAST 798.9794 MsbA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • lipid transporter activity
    		•  7.47642599298853 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • peptide transporter activity
    		•  4.7442815698413 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  4.71935767060308 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  4.63590351019108 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • oligopeptide-transporting ATPase activity
    		•  4.09365342567844 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • phosphate transmembrane-transporting ATPase activity
    		•  3.20894563245332 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  3.16975154423199 bayes_pls_golite062009
  • hydrolase activity
    		•  3.14498892233323 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.13913638619234 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • ATP binding
    		•  3.01346604299372 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.00745742755195 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.96271391116269 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.91131545957759 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.70262534541085 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.70178191749524 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.6583477492092 bayes_pls_golite062009
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • sterol transporter activity
    		•  2.48473697371886 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • vitamin transporter activity
    		•  2.1653565229854 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  2.15147988861177 bayes_pls_golite062009
  • oligopeptide transporter activity
    		•  2.05580564974083 bayes_pls_golite062009
  • L-aspartate transmembrane transporter activity
    		•  2.05274761921715 bayes_pls_golite062009
  • binding
    		•  1.84115074893083 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • organic anion transmembrane transporter activity
    		•  1.76999970080179 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.52921795164482 bayes_pls_golite062009
  • phosphonate transmembrane transporter activity
    		•  1.40269234722336 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • molybdate ion transmembrane transporter activity
    		•  1.28313088935613 bayes_pls_golite062009
  • molybdate transmembrane-transporting ATPase activity
    		•  1.28313088935613 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • DNA binding
    		•  1.19966224604123 bayes_pls_golite062009
  • potassium channel activity
    		•  1.17288958041707 bayes_pls_golite062009
  • sulfate transmembrane-transporting ATPase activity
    		•  1.1220946941463 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.09075553688438 bayes_pls_golite062009
  • dipeptide transporter activity
    		•  1.01130176523309 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • thiamin transmembrane transporter activity
    		•  0.933872128802939 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.860102064846772 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  0.798934081014025 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  0.644421039250979 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.640772201693186 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.63468044350616 bayes_pls_golite062009
  • GTP binding
    		•  0.621689261700018 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.442220326523999 bayes_pls_golite062009
  • ligase activity
    		•  0.417681194526243 bayes_pls_golite062009
  • catalytic activity
    		•  0.368034275052766 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • signal transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.20866768220789 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • structural molecule activity
    		•  0.11239762372728 bayes_pls_golite062009
  • sulfate transmembrane transporter activity
    		•  0.104477131120205 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0612932659603008 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle