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Protein Overview: SQT1

General Information:
Name(s) found: SQT1 / YIR012W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 431 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    ribosomal large subunit assembly [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPQEEFITT EEVEQEIVPT VEVEQDVPVD IEGENDDDDE MMNDDEEALE VDMSNNSLTY  60
   61 FDKHTDSVFA IGHHPNLPLV CTGGGDNLAH LWTSHSQPPK FAGTLTGYGE SVISCSFTSE 120
  121 GGFLVTADMS GKVLVHMGQK GGAQWKLASQ MQEVEEIVWL KTHPTIARTF AFGATDGSVW 180
  181 CYQINEQDGS LEQLMSGFVH QQDCSMGEFI NTDKGENTLE LVTCSLDSTI VAWNCFTGQQ 240
  241 LFKITQAEIK GLEAPWISLS LAPETLTKGN SGVVACGSNN GLLAVINCNN GGAILHLSTV 300
  301 IELKPEQDEL DASIESISWS SKFSLMAIGL VCGEILLYDT SAWRVRHKFV LEDSVTKLMF 360
  361 DNDDLFASCI NGKVYQFNAR TGQEKFVCVG HNMGVLDFIL LHPVANTGTE QKRKVITAGD 420
  421 EGVSLVFEVP N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Ho Y, et al. (2002) BZZ1 GAL2 HXT7 LAS17 PEP1 PHO84 RPN1 RPN12 RVS167 SLA1 SQT1 VMA6 YHM2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DMC1 SQT1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SQT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] PSI-BLAST 24.69897 Groucho/tle1, C-terminal domain
    2 View Details [98..431] PSI-BLAST 73.221849 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 3.73992288706975 bayes_pls_golite062009
  • structural molecule activity
    		•  3.73518050245315 bayes_pls_golite062009
  • snoRNA binding
    		•  2.69983094099712 bayes_pls_golite062009
  • RNA binding
    		•  2.3514111482663 bayes_pls_golite062009
  • binding
    		•  2.2778252170547 bayes_pls_golite062009
  • protein binding
    		•  1.42618832381942 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.722742354759599 bayes_pls_golite062009
  • actin binding
    		•  0.00606924241186668 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle