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Protein Overview: NUP159

General Information:
Name(s) found: NUP159 / YIL115C [SGD]
Description(s) found:
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  • gi|806505|gb|AAC41652.1| nucleoporin [NCBI NR]
  • gi|731862|sp|P40477.1|NU159_YEAST RecName: Full=Nucleoporin NUP159; AltName: Full=Nuclear pore protein NUP159 [NCBI NR]
  • gi|6322076|ref|NP_012151.1| Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export; Nup159p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48457 nucleoporin RAT7 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|558691|emb|CAA86265.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Nucleoporin NUP159 OS=Saccharomyces cerevisiae GN=NUP159 PE=1 SV=1 [Swiss-Prot]
  • (P40477) Nucleoporin NUP159 (Nuclear pore protein NUP159) [Swiss-Prot]
  • NUP159 Nuclear pore protein [mips]
  • Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, member of the Nup82 subcomplex, required for mRNA export [SGD]
  • NUP159, Chr IX from 144324-148706, reverse complement [yeast_orfs2]
  • Chr IX from 144324-148706, reverse complement [yeastorf3.fasta]
  • Chr IX from 148706-144324, reverse complement [yeastorf5.fasta]
  • NUP159 SGDID:S0001377, Chr IX from 148706-144324, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Nup159p [Saccharomyces cerevisiae]gi|558691|emb|CAA86265.1| unnamed protein product [Saccharomyces cerevisiae]gi|626362|pir||S48457 nucleoporin RAT7 - yeast (Saccharomyces cerevisiae)gi|806505|gb|AAC41652.1| nucleoporingi|731862|sp|P40477|N159_YEAST N [nrdb_11152004_Chlamydomonas]
  • NUP159 SGDID:S000001377, Chr IX from 148706-144324, reverse complement, Verified ORF, "Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • NUP159 SGDID:S000001377, Chr IX from 148706-144324, reverse complement, Verified ORF, "Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export; Nup159p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • nucleoporin [nr-271106-contam.fasta]
  • Nucleoporin NUP159 (Nuclear pore protein NUP159) [nr-271106-contam.fasta]
  • NUP159 SGDID:S000001377, Chr IX from 148706-144324, reverse complement, Verified ORF, "Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, member of the Nup82 subcomplex, required for mRNA export" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • Nucleoporin NUP159 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUP159 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NUP159 SGDID:S000001377, Chr IX from 148709-144327, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleoporin, subunit of the Nup82 subcomplex of the nuclear pore; part of the nuclear pore that is found exclusively on the cytoplasmic side; required for mRNA export; regulates ADP release from the ATP-dependent RNA helicase Dbp5p" [yeast-030211-contam.fasta]
  • NUP159 SGDID:S000001377, Chr IX from 148709-144327, Genome Release 64-2-1, reverse complement, Verified ORF, "FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)" [20141208_orf_trans.fasta]
  • YIL115C SGDID:S000001377, Chr IX from 148709-144327, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleoporin, subunit of the Nup82 subcomplex of the nuclear pore; part of the nuclear pore that is found exclusively on the cytoplasmic side; required for mRNA export; regulates ADP release from the ATP-dependent RNA helicase Dbp5p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1460 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [TASLink to PubMed article]
    Biological Process: mRNA export from nucleus [IMPLink to PubMed article]
    rRNA export from nucleus [IMPLink to PubMed article]
    ribosomal subunit export from nucleus [IMPLink to PubMed article]
    nuclear pore organization [IMPLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLKDEVPT ETSEDFGFKF LGQKQILPSF NEKLPFASLQ NLDISNSKSL FVAASGSKAV  60
   61 VGELQLLRDH ITSDSTPLTF KWEKEIPDVI FVCFHGDQVL VSTRNALYSL DLEELSEFRT 120
  121 VTSFEKPVFQ LKNVNNTLVI LNSVNDLSAL DLRTKSTKQL AQNVTSFDVT NSQLAVLLKD 180
  181 RSFQSFAWRN GEMEKQFEFS LPSELEELPV EEYSPLSVTI LSPQDFLAVF GNVISETDDE 240
  241 VSYDQKMYII KHIDGSASFQ ETFDITPPFG QIVRFPYMYK VTLSGLIEPD ANVNVLASSC 300
  301 SSEVSIWDSK QVIEPSQDSE RAVLPISEET DKDTNPIGVA VDVVTSGTIL EPCSGVDTIE 360
  361 RLPLVYILNN EGSLQIVGLF HVAAIKSGHY SINLESLEHE KSLSPTSEKI PIAGQEQEEK 420
  421 KKNNESSKAL SENPFTSANT SGFTFLKTQP AAANSLQSQS SSTFGAPSFG SSAFKIDLPS 480
  481 VSSTSTGVAS SEQDATDPAS AKPVFGKPAF GAIAKEPSTS EYAFGKPSFG APSFGSGKSS 540
  541 VESPASGSAF GKPSFGTPSF GSGNSSVEPP ASGSAFGKPS FGTPSFGSGN SSAEPPASGS 600
  601 AFGKPSFGTS AFGTASSNET NSGSIFGKAA FGSSSFAPAN NELFGSNFTI SKPTVDSPKE 660
  661 VDSTSPFPSS GDQSEDESKS DVDSSSTPFG TKPNTSTKPK TNAFDFGSSS FGSGFSKALE 720
  721 SVGSDTTFKF GTQASPFSSQ LGNKSPFSSF TKDDTENGSL SKGSTSEIND DNEEHESNGP 780
  781 NVSGNDLTDS TVEQTSSTRL PETPSDEDGE VVEEEAQKSP IGKLTETIKK SANIDMAGLK 840
  841 NPVFGNHVKA KSESPFSAFA TNITKPSSTT PAFSFGNSTM NKSNTSTVSP MEEADTKETS 900
  901 EKGPITLKSV ENPFLPAKEE RTGESSKKDH NDDPKDGYVS GSEISVRTSE SAFDTTANEE 960
  961 IPKSQDVNNH EKSETDPKYS QHAVVDHDNK SKEMNETSKN NERSGQPNHG VQGDGIALKK1020
 1021 DNEKENFDSN MAIKQFEDHQ SSEEDASEKD SRQSSEVKES DDNMSLNSDR DESISESYDK1080
 1081 LEDINTDELP HGGEAFKARE VSASADFDVQ TSLEDNYAES GIQTDLSESS KENEVQTDAI1140
 1141 PVKHNSTQTV KKEAVDNGLQ TEPVETCNFS VQTFEGDENY LAEQCKPKQL KEYYTSAKVS1200
 1201 NIPFVSQNST LRLIESTFQT VEAEFTVLME NIRNMDTFFT DQSSIPLVKR TVRSINNLYT1260
 1261 WRIPEAEILL NIQNNIKCEQ MQITNANIQD LKEKVTDYVR KDIAQITEDV ANAKEEYLFL1320
 1321 MHFDDASSGY VKDLSTHQFR MQKTLRQKLF DVSAKINHTE ELLNILKLFT VKNKRLDDNP1380
 1381 LVAKLAKESL ARDGLLKEIK LLREQVSRLQ LEEKGKKASS FDASSSITKD MKGFKVVEVG1440
 1441 LAMNTKKQIG DFFKNLNMAK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NSP1 NUP159 NUP82
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Krogan NJ, et al. (2006) NSP1 NUP133 NUP159 NUP82
    View Details Gavin AC, et al. (2006) NSP1 NUP159 NUP82
    View Details Gavin AC, et al. (2002) MRPL1 MRPL15 MRPL24 MRPL3 MRPL35 MRPL8 NIC96 NSP1 NUP116 NUP159 NUP82 YML6
    View Details Qiu et al. (2008) ASM4 GLE2 KAP120 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP49 NUP53 NUP57 NUP82 NUP84 NUP85 POM152

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUP159 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] deduced N/A No confident structure predictions are available.
    2 View Details [133..609] MSA 8.207997 View MSA. No confident structure predictions are available.
    3 View Details [610..935] MSA 1.212997 View MSA. No confident structure predictions are available.
    4 View Details [936..1376] MSA 10.217996 View MSA. No confident structure predictions are available.
    5 View Details [1377..1460] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleocytoplasmic transporter activity
    		•  7.36869426424539 bayes_pls_golite062009
  • transporter activity
    		•  2.55928656852707 bayes_pls_golite062009
  • binding
    		•  1.85720332251545 bayes_pls_golite062009
  • structural molecule activity
    		•  1.15400876251633 bayes_pls_golite062009
  • protein binding
    		•  0.756333887228113 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle