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Protein Overview: PRK1

General Information:
Name(s) found: PRK1 / YIL095W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 810 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: cytokinesis [IMPLink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    regulation of endocytosis [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    actin cortical patch assembly [TASLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTPQISLYE PGTILTVGSH HAKIIKYLTS GGFAQVYTAE ISPPDPYSNA NIACLKRVIV  60
   61 PHKQGLNTLR AEVDAMKLLR NNKHVVSYID SHAARSVNGI AYEVFVLMEF CERGGLIDFM 120
  121 NTRLQNRLQE SEILEIMSQT VQGITAMHAL QPPLIHRDIK IENVLISHDG LYKVCDFGSV 180
  181 SGVIRPPRNT QEFNYVQHDI LTNTTAQYRS PEMIDLYRGL PIDEKSDIWA LGVFLYKICY 240
  241 YTTPFEKSGE AGILHARYQY PSFPQYSDRL KNLIRLMLME APSQRPNICQ VLEEVSRLQN 300
  301 KPCPIRNFYL LRAMNQNANT QLAGEPSSTT YVPTQKFIPV QSLQSINQPP NMMPVTHVST 360
  361 TPNLGTFPIS INDNNKTEVT AHAGLQVGSH SNLTSPLMKT KSVPLSDEFA SLYYKELHPF 420
  421 QKSQTFKSVE SFQSPQRKSM PPLSLTPVNN DIFDRVSAIN RPNNYVDSET QTIDNMAVPN 480
  481 LKLSPTITSK SLSSTKEIAA PDNINGSKIV RSLSSKLKKV ITGESRGNSP IKSRQNTGDS 540
  541 IRSAFGKLRH GFTGNSVNNS RSASFDNNNV NGNGNNTNRR LVSSSTSSFP KFNSDTKRKE 600
  601 ESDKNQRLEK RRSMPPSILS DFDQHERNNS RTGSRDYYRS HSPVKKTQAS AKTTSKPTLI 660
  661 PDNGNVNINQ EKKESIQRRV HNLLKSSDDP VTYKSASGYG KYTDIGTETS NRHSSVRITP 720
  721 ITEEKFKKTL KDGVLDIKTK SNGKDKSRPP RPPPKPLHLR TEIQKIRNFS RLQSKKLPIE 780
  781 RISSEATETI VDVNVDDLEA DFRKRFPSKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABP1 BSP1 CRN1 NOP53 PRK1 RPL3 RPL36A
    View Details Krogan NJ, et al. (2006) APN2 BFR1 BRX1 BUR2 LOC1 NHP6A PRK1 RIM1 SGV1 SPB1 TMA64 TSR1
    View Details Ho Y, et al. (2002) ABP1 AKL1 ECM10 PRK1
    View Details Qiu et al. (2008) ARK1 ENT1 PRK1 SLA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GBP2 PRK1 1 Unpublished Fields Lab Data
    View Screen EST1 PRK1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRK1 and SAC6 Huh WK, et al. (2003)
    View Data PRK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70]
    [89..109]    		 PSI-BLAST 222.201249 gamma-subunit of glycogen phosphorylase kinase (Phk)
    2 View Details [71..88]
    [110..351]    		 PSI-BLAST 222.201249 gamma-subunit of glycogen phosphorylase kinase (Phk)
    3 View Details [352..810] deduced N/A No confident structure predictions are available.
    4 View Details [709..810] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein kinase activity
    		•  4.05475891009228 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.7974128326421 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.59230737331367 bayes_pls_golite062009
  • kinase activity
    		•  3.41737435609334 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.2342722637405 bayes_pls_golite062009
  • binding
    		•  2.41732321506551 bayes_pls_golite062009
  • transferase activity
    		•  2.04713540681686 bayes_pls_golite062009
  • protein binding
    		•  1.75479345161448 bayes_pls_golite062009
  • ATP binding
    		•  1.44435058039859 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.41005152726625 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.38971642420542 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.16863558166547 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.16859376715941 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.15633908642115 bayes_pls_golite062009
  • nucleotide binding
    		•  1.14964488472581 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • AMP-activated protein kinase activity
    		•  0.496765880715405 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.439688030503848 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle