Protein Overview: PDR11

General Information:
Name(s) found:	PDR11 / YIL013C [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth [SGD]
Organism:	Saccharomyces cerevisiae
Length:	1411 amino acids
Gene Ontology:
Cellular Component:	membrane [ISS]
Biological Process:	sterol transport [IMP]
Molecular Function:	ATPase activity, coupled to transmembrane movement of substances [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS DITFRANEGE  60
   61 VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ FASKCPHQII YNNEQDIHFP 120
  121 YLTVEQTIDF ALSCKFHIPK QERIEMRDEL LKEFGLSHVK KTYVGNDYVR GVSGGERKRI 180
  181 SIIETFIANG SVYLWDNSTK GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF 240
  241 DKILMLGDSF QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETSNSIVGL 300
  301 DTPSVVSEEN QALNINNETD LHTLWIQSPY YKHWKAITSK TVQECTRKDV NPDDISPIFS 360
  361 IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG SLFYNIPLTT IGSFSRGSLT 420
  421 FFSILFFTFL SLADMPASFQ RQPVVRKHVQ LHFYYNWVET LATNFFDCCS KFILVVIFTI 480
  481 ILYFLAHLQY NAARFFIFLL FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY 540
  541 ASYVIYMKDM HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHESIIPRG EYYDNISFSH 600
  601 KACAWQGATL GNDYVRGRDY LKSGLKYTYH HVWRNFGIII GFLCFFLFCS LLAAEYITPL 660
  661 FTRENLLRWN NYLKRYCPFL NSQKKNNKSA ITNNDGVCTP KTPIANFSTS SSSVPSVSHQ 720
  721 YDTDYNIKHP DETVNNHTKE SVAMETQKHV ISWKNINYTI GDKKLINDAS GYISSGLTAL 780
  781 MGESGAGKTT LLNVLSQRTE SGVVTGELLI DGQPLTNIDA FRRSIGFVQQ QDVHLELLTV 840
  841 RESLEISCVL RGDGDRDYLG VVSNLLRLPS EKLVADLSPT QRKLLSIGVE LVTKPSLLLF 900
  901 LDEPTSGLDA EAALTIVQFL KKLSMQGQAI LCTIHQPSKS VISYFDNIYL LKRGGECVYF 960
  961 GSLPNACDYF VAHDRRLTFD REMDNPADFV IDVVGSGSTN IPMDDAEKPT SSKIDEPVSY1020
 1021 HKQSDSINWA ELWQSSPEKV RVADDLLLLE EEARKSGVDF TTSVWSPPSY MEQIKLITKR1080
 1081 QYICTKRDMT YVFAKYALNA GAGLFIGFSF WRTKHNINGL QDAIFLCFMM LCVSSPLINQ1140
 1141 VQDKALQSKE VYIAREARSN TYHWTVLLIA QTIVELPLAI SSSTLFFLCC YFCCGFETSA1200
 1201 RVAGVFYLNY ILFSMYYLSF GLWLLYSAPD LQTAAVFVAF LYSFTASFCG VMQPYSLFPR1260
 1261 FWTFMYRVSP YTYFIETFVS LLLHDREVNC STSEMVPSQP VMGQTCGQFM KPFIDEFGGK1320
 1321 LHINNTYTVC AYCMYTVGDD FLAQENMSYH HRWRNFGFEW VFVCFNIAAM FVGFYLTYIK1380
 1381 KIWPSVIDGI KKCIPSMRRS KTSHNPNEQS V

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD6	PDR11	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..294]	PSI-BLAST	133.68867	MJ0796
2	View Details	[295..360]	deduced	N/A	No confident structure predictions are available.
3	View Details	[361..584]	MSA	1.358966	View MSA. No confident structure predictions are available.
4	View Details	[585..728]	deduced	N/A	No confident structure predictions are available.
5	View Details	[729..1055]	PSI-BLAST	140.927757	Maltose transport protein MalK, C-terminal domain; Maltose transport protein MalK, N-terminal domain
6	View Details	[1056..1316]	MSA	4.234958	View MSA. No confident structure predictions are available.
7	View Details	[1317..1411]	deduced	N/A	Confident ab initio structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity	6.58863529263644	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	6.58067278719409	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	6.57974651657836	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	6.57922174989907	bayes_pls_golite062009
primary active transmembrane transporter activity	6.57807080367604	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.48406410175216	bayes_pls_golite062009
active transmembrane transporter activity	6.48154954364331	bayes_pls_golite062009
pyrophosphatase activity	6.40467109535527	bayes_pls_golite062009
ATPase activity, coupled	6.40151534181487	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.38373914253885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.38247436082206	bayes_pls_golite062009
ATPase activity	6.30019941712404	bayes_pls_golite062009
hydrolase activity	4.60957912556603	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
purine ribonucleotide binding	3.40690615950081	bayes_pls_golite062009
ribonucleotide binding	3.40594996232845	bayes_pls_golite062009
purine nucleotide binding	3.3669118613715	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
nucleotide binding	3.33248266870364	bayes_pls_golite062009
ATP binding	3.17398570826788	bayes_pls_golite062009
adenyl ribonucleotide binding	3.12628113185041	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
adenyl nucleotide binding	3.0710107594224	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.88795687640992	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
syntaxin-13 binding	2.15656963765495	bayes_pls_golite062009
apolipoprotein receptor activity	2.15656963765495	bayes_pls_golite062009
apolipoprotein A-I binding	2.15656963765495	bayes_pls_golite062009
apolipoprotein A-I receptor activity	2.15656963765495	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	2.12727614888121	bayes_pls_golite062009
binding	2.0681607836408	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	1.88153949603611	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
fluconazole transporter activity	1.75428613304237	bayes_pls_golite062009
azole transporter activity	1.75428613304237	bayes_pls_golite062009
cholesterol transporter activity	1.61368800389403	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
sterol transporter activity	1.49412408393009	bayes_pls_golite062009
peptide-transporting ATPase activity	1.37783759788533	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
peptide transporter activity	1.19353064661766	bayes_pls_golite062009
potassium channel activity	1.17288958041707	bayes_pls_golite062009
lipid transporter activity	1.10957173853622	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
nucleic acid binding	0.896078342024449	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
	0.869999622006359	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
phospholipid transporter activity	0.755445322666929	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
DNA-dependent ATPase activity	0.62832939629645	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
DNA binding	0.361518668029935	bayes_pls_golite062009
GTPase activity	0.20164416416912	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
motor activity	0.14734538548583	bayes_pls_golite062009
transcription regulator activity	0.133605084599819	bayes_pls_golite062009
protein transporter activity	0.104820191623932	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
structure-specific DNA binding	0.050232896280066	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity	6.58863529263644	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	6.58067278719409	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	6.57974651657836	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	6.57922174989907	bayes_pls_golite062009
primary active transmembrane transporter activity	6.57807080367604	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.48406410175216	bayes_pls_golite062009
active transmembrane transporter activity	6.48154954364331	bayes_pls_golite062009
pyrophosphatase activity	6.40467109535527	bayes_pls_golite062009
ATPase activity, coupled	6.40151534181487	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.38373914253885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.38247436082206	bayes_pls_golite062009
ATPase activity	6.30019941712404	bayes_pls_golite062009
hydrolase activity	4.60957912556603	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
purine ribonucleotide binding	3.40690615950081	bayes_pls_golite062009
ribonucleotide binding	3.40594996232845	bayes_pls_golite062009
purine nucleotide binding	3.3669118613715	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
nucleotide binding	3.33248266870364	bayes_pls_golite062009
ATP binding	3.17398570826788	bayes_pls_golite062009
adenyl ribonucleotide binding	3.12628113185041	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
adenyl nucleotide binding	3.0710107594224	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.88795687640992	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.61311581579476	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
apolipoprotein A-I receptor activity	2.15656963765495	bayes_pls_golite062009
apolipoprotein receptor activity	2.15656963765495	bayes_pls_golite062009
syntaxin-13 binding	2.15656963765495	bayes_pls_golite062009
apolipoprotein A-I binding	2.15656963765495	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	2.12727614888121	bayes_pls_golite062009
transporter activity	1.9862037182943	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	1.88153949603611	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
fluconazole transporter activity	1.75428613304237	bayes_pls_golite062009
azole transporter activity	1.75428613304237	bayes_pls_golite062009
cholesterol transporter activity	1.61368800389403	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
binding	1.49433277484566	bayes_pls_golite062009
sterol transporter activity	1.49412408393009	bayes_pls_golite062009
peptide-transporting ATPase activity	1.37783759788533	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
peptide transporter activity	1.19353064661766	bayes_pls_golite062009
potassium channel activity	1.17288958041707	bayes_pls_golite062009
lipid transporter activity	1.10957173853622	bayes_pls_golite062009
nucleic acid binding	1.02585080387771	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription regulator activity	0.960964717764622	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
	0.869999622006359	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
DNA binding	0.827956993331319	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
phospholipid transporter activity	0.755445322666929	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
DNA-dependent ATPase activity	0.62832939629645	bayes_pls_golite062009
transition metal ion binding	0.565091767161677	bayes_pls_golite062009
transcription factor activity	0.529204993559159	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
GTPase activity	0.20164416416912	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
motor activity	0.14734538548583	bayes_pls_golite062009
protein transporter activity	0.104820191623932	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
structure-specific DNA binding	0.050232896280066	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2