Protein Overview: SCH9

General Information:
Name(s) found:	SCH9 / YHR205W [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB [SGD]
Organism:	Saccharomyces cerevisiae
Length:	824 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA] fungal-type vacuole membrane [IDA]
Biological Process:	regulation of cell size [IMP] protein amino acid phosphorylation [IGI][ISS] replicative cell aging [IMP] age-dependent response to oxidative stress involved in chronological cell aging [IMP]
Molecular Function:	protein serine/threonine kinase activity [IGI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNFFTSKSS NQDTGFSSQH QHPNGQNNGN NNSSTAGNDN GYPCKLVSSG PCASSNNGAL  60
   61 FTNFTLQTAT PTTAISQDLY AMGTTGITSE NALFQMKSMN NGISSVNNNN SNTPTIITTS 120
  121 QEETNAGNVH GDTGGNSLQN SEDDNFSSSS TTKCLLSSTS SLSINQREAA AAAYGPDTDI 180
  181 PRGKLEVTII EARDLVTRSK DSQPYVVCTF ESSEFISNGP ESLGAINNNN NNNNNNQHNQ 240
  241 NQHINNNNEN TNPDAASQHH NNNSGWNGSQ LPSIKEHLKK KPLYTHRSSS QLDQLNSCSS 300
  301 VTDPSKRSSN SSSGSSNGPK NDSSHPIWHH KTTFDVLGSH SELDISVYDA AHDHMFLGQV 360
  361 RLYPMIHNLA HASQHQWHSL KPRVIDEVVS GDILIKWTYK QTKKRHYGPQ DFEVLRLLGK 420
  421 GTFGQVYQVK KKDTQRIYAM KVLSKKVIVK KNEIAHTIGE RNILVTTASK SSPFIVGLKF 480
  481 SFQTPTDLYL VTDYMSGGEL FWHLQKEGRF SEDRAKFYIA ELVLALEHLH DNDIVYRDLK 540
  541 PENILLDANG NIALCDFGLS KADLKDRTNT FCGTTEYLAP ELLLDETGYT KMVDFWSLGV 600
  601 LIFEMCCGWS PFFAENNQKM YQKIAFGKVK FPRDVLSQEG RSFVKGLLNR NPKHRLGAID 660
  661 DGRELRAHPF FADIDWEALK QKKIPPPFKP HLVSETDTSN FDPEFTTAST SYMNKHQPMM 720
  721 TATPLSPAMQ AKFAGFTFVD ESAIDEHVNN NRKFLQNSYF MEPGSFIPGN PNLPPDEDVI 780
  781 DDDGDEDIND GFNQEKNMNN SHSQMDFDGD QHMDDEFVSG RFEI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RBA50	No Comments	Hazbun TR, et al. (2003)
View Run	SWC4	No Comments	Hazbun TR, et al. (2003)
View Run	IPI3	No Comments	Hazbun TR, et al. (2003)
View Run	DSN1	No Comments	Hazbun TR, et al. (2003)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SCH9	PPT1	2	Unpublished Fields Lab Data
View Screen	SCH9	VHS2	2	Unpublished Fields Lab Data
View Screen	SCH9	YIL152W	2	Unpublished Fields Lab Data
View Screen	SCH9	YIR014W	2	Unpublished Fields Lab Data
View Screen	SCH9	CPR6	2	Unpublished Fields Lab Data
View Screen	ILM1	SCH9	1	Lockshon D, et al. (2006)
View Screen	RAD6	SCH9	1	Unpublished Fields Lab Data
View Screen	MET18	SCH9	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SCH9	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..140]	deduced	N/A	No confident structure predictions are available.
2	View Details	[141..219]	PSI-BLAST	16.522879	Protein kinase c-gamma
3	View Details	[220..352]	PSI-BLAST	19.0	C2 domain from protein kinase c (alpha)
4	View Details	[353..402] [459..477] [495..695]	PSI-BLAST	887.9897	cAMP-dependent PK, catalytic subunit
5	View Details	[403..458] [478..494] [696..750]	PSI-BLAST	887.9897	cAMP-dependent PK, catalytic subunit
6	View Details	[751..824]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	3.39366632218663	bayes_pls_golite062009
transcription regulator activity	2.86705824967236	bayes_pls_golite062009
binding	2.79128751898373	bayes_pls_golite062009
nucleic acid binding	2.21939548334548	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.10625597744594	bayes_pls_golite062009
DNA binding	2.06132216820898	bayes_pls_golite062009
kinase activity	2.03632850156074	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.01398134569666	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.8531437045627	bayes_pls_golite062009
protein kinase activity	1.62921423829738	bayes_pls_golite062009
transferase activity	1.4550521488922	bayes_pls_golite062009
transcription factor activity	1.39657429296564	bayes_pls_golite062009
GTPase regulator activity	1.39167263636091	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.37139209958305	bayes_pls_golite062009
protein binding	1.29100556128076	bayes_pls_golite062009
signal transducer activity	1.25507073225414	bayes_pls_golite062009
molecular transducer activity	1.25507073225414	bayes_pls_golite062009
protein serine/threonine kinase activity	0.956859696337723	bayes_pls_golite062009
enzyme regulator activity	0.911061212692491	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.907368864863833	bayes_pls_golite062009
small GTPase regulator activity	0.661240850692236	bayes_pls_golite062009
kinase binding	0.494958567742569	bayes_pls_golite062009
catalytic activity	0.194464246602439	bayes_pls_golite062009

Term	Confidence	Notes
calcium-dependent phospholipid binding	3.93415448210371	bayes_pls_golite062009
binding	2.77482286467294	bayes_pls_golite062009
phospholipid binding	2.74013385479058	bayes_pls_golite062009
neurexin binding	1.99616093461872	bayes_pls_golite062009
lipid binding	1.47484095830847	bayes_pls_golite062009
protein binding	1.33917246836907	bayes_pls_golite062009
receptor activity	1.33810899162617	bayes_pls_golite062009
transporter activity	1.2628067945512	bayes_pls_golite062009
signal transducer activity	1.10701462579828	bayes_pls_golite062009
molecular transducer activity	1.10701462579828	bayes_pls_golite062009
substrate-specific transporter activity	0.816751946072324	bayes_pls_golite062009
hydrolase activity	0.60498030953036	bayes_pls_golite062009
SNARE binding	0.3731056408292	bayes_pls_golite062009
profilin binding	0.32399339703241	bayes_pls_golite062009
syntaxin-1 binding	0.273890767897551	bayes_pls_golite062009
calmodulin binding	0.26906635924237	bayes_pls_golite062009
receptor binding	0.189665306346323	bayes_pls_golite062009

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity	4.97855712164511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cAMP-dependent protein kinase activity	4.66277812893755	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
acetylcholine receptor activator activity	1.83545227594542	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.82515074380651	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
ErbB-3 class receptor binding	1.25765701903393	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
tubulin binding	1.13686658158825	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
ErbB-2 class receptor binding	1.02996109010965	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.99838484913572	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
microtubule binding	0.734274677384472	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity	0.688047400629641	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.401250804041384	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
receptor binding	0.197402253061255	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2