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View Structure Prediction Details

Protein: SCH9
Organism: Saccharomyces cerevisiae
Length: 824 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SCH9.

Description E-value Query
Range		 Subject
Range
SCH9_YEAST - Serine/threonine-protein kinase SCH9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCH...
SCH9 - Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 p...
gi|190405980 - gi|190405980|gb|EDV09247.1| serine/threonine-protein kinase SCH9 [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..824] [1..824]
KPCA_RAT - Protein kinase C alpha type OS=Rattus norvegicus GN=Prkca PE=1 SV=3
gi|56914 - gi|56914|emb|CAA30266.1| unnamed protein product [Rattus rattus]
 0.0 [142..750] [80..670]
PRKCB1 - protein kinase C, beta 1
 0.0 [142..744] [80..668]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [142..750] [80..670]
KPCB_RABIT - Protein kinase C beta type OS=Oryctolagus cuniculus GN=PRKCB PE=2 SV=3
 0.0 [142..744] [80..668]
KPCA_BOVIN - Protein kinase C alpha type OS=Bos taurus GN=PRKCA PE=1 SV=3
 0.0 [142..750] [80..670]
gi|226574, gi|55132 - gi|55132|emb|CAA36907.1| protein kinase C [Mus musculus], gi|226574|prf||1602247A protein kinase C m...
 0.0 [142..750] [80..670]

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Predicted Domain #1
Region A:
Residues: [1-140] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNFFTSKSS NQDTGFSSQH QHPNGQNNGN NNSSTAGNDN GYPCKLVSSG PCASSNNGAL  60
   61 FTNFTLQTAT PTTAISQDLY AMGTTGITSE NALFQMKSMN NGISSVNNNN SNTPTIITTS 120
  121 QEETNAGNVH GDTGGNSLQN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [141-219] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEDDNFSSSS TTKCLLSSTS SLSINQREAA AAAYGPDTDI PRGKLEVTII EARDLVTRSK  60
   61 DSQPYVVCTF ESSEFISNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1tbn__
Description: Protein kinase c-gamma
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.39366632218663 bayes_pls_golite062009
transcription regulator activity 2.86705824967236 bayes_pls_golite062009
binding 2.79128751898373 bayes_pls_golite062009
nucleic acid binding 2.21939548334548 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.10625597744594 bayes_pls_golite062009
DNA binding 2.06132216820898 bayes_pls_golite062009
kinase activity 2.03632850156074 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.01398134569666 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.8531437045627 bayes_pls_golite062009
protein kinase activity 1.62921423829738 bayes_pls_golite062009
transferase activity 1.4550521488922 bayes_pls_golite062009
transcription factor activity 1.39657429296564 bayes_pls_golite062009
GTPase regulator activity 1.39167263636091 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.37139209958305 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
signal transducer activity 1.25507073225414 bayes_pls_golite062009
molecular transducer activity 1.25507073225414 bayes_pls_golite062009
protein serine/threonine kinase activity 0.956859696337723 bayes_pls_golite062009
enzyme regulator activity 0.911061212692491 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.907368864863833 bayes_pls_golite062009
small GTPase regulator activity 0.661240850692236 bayes_pls_golite062009
kinase binding 0.494958567742569 bayes_pls_golite062009
catalytic activity 0.194464246602439 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [220-352] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PESLGAINNN NNNNNNNQHN QNQHINNNNE NTNPDAASQH HNNNSGWNGS QLPSIKEHLK  60
   61 KKPLYTHRSS SQLDQLNSCS SVTDPSKRSS NSSSGSSNGP KNDSSHPIWH HKTTFDVLGS 120
  121 HSELDISVYD AAH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1dsyA_
Description: C2 domain from protein kinase c (alpha)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
calcium-dependent phospholipid binding 3.93415448210371 bayes_pls_golite062009
binding 2.77482286467294 bayes_pls_golite062009
phospholipid binding 2.74013385479058 bayes_pls_golite062009
neurexin binding 1.99616093461872 bayes_pls_golite062009
lipid binding 1.47484095830847 bayes_pls_golite062009
protein binding 1.33917246836907 bayes_pls_golite062009
receptor activity 1.33810899162617 bayes_pls_golite062009
transporter activity 1.2628067945512 bayes_pls_golite062009
signal transducer activity 1.10701462579828 bayes_pls_golite062009
molecular transducer activity 1.10701462579828 bayes_pls_golite062009
substrate-specific transporter activity 0.816751946072324 bayes_pls_golite062009
hydrolase activity 0.60498030953036 bayes_pls_golite062009
SNARE binding 0.3731056408292 bayes_pls_golite062009
profilin binding 0.32399339703241 bayes_pls_golite062009
syntaxin-1 binding 0.273890767897551 bayes_pls_golite062009
calmodulin binding 0.26906635924237 bayes_pls_golite062009
receptor binding 0.189665306346323 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [353-402] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHMFLGQVRL YPMIHNLAHA SQHQWHSLKP RVIDEVVSGD ILIKWTYKQT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [459-477] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GERNILVTTA SKSSPFIVG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [495-695] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGGELFWHL QKEGRFSEDR AKFYIAELVL ALEHLHDNDI VYRDLKPENI LLDANGNIAL  60
   61 CDFGLSKADL KDRTNTFCGT TEYLAPELLL DETGYTKMVD FWSLGVLIFE MCCGWSPFFA 120
  121 ENNQKMYQKI AFGKVKFPRD VLSQEGRSFV KGLLNRNPKH RLGAIDDGRE LRAHPFFADI 180
  181 DWEALKQKKI PPPFKPHLVS E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 887.9897
Match: 1cdkA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
tubulin binding 1.13686658158825 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
ErbB-2 class receptor binding 1.02996109010965 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.99838484913572 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
microtubule binding 0.734274677384472 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 0.688047400629641 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
receptor binding 0.197402253061255 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [403-458] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRHYGPQDF EVLRLLGKGT FGQVYQVKKK DTQRIYAMKV LSKKVIVKKN EIAHTI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [478-494] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKFSFQTPTD LYLVTDY

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [696-750] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDTSNFDPEF TTASTSYMNK HQPMMTATPL SPAMQAKFAG FTFVDESAID EHVNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 887.9897
Match: 1cdkA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [751-824] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRKFLQNSYF MEPGSFIPGN PNLPPDEDVI DDDGDEDIND GFNQEKNMNN SHSQMDFDGD  60
   61 QHMDDEFVSG RFEI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle