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Protein Overview: KPCA_RAT

General Information:
Name(s) found: KPCA_RAT [Swiss-Prot]
Description(s) found:
Found 12 descriptions.
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  • Protein kinase C alpha type OS=Rattus norvegicus GN=Prkca PE=1 SV=3 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 672 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN][IDA]
    nucleus [UNKNOWN][IEA]
    synaptosome [IDA]
    cytoplasm [UNKNOWN][IEA]
    mitochondrion [UNKNOWN][IDA]
    membrane raft [IDA]
    cytosol [UNKNOWN][IDA]
    protein complex [IDA]
    plasma membrane [UNKNOWN][IDA]
    Biological Process: central nervous system neuron axonogenesis [IMP]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    chondrocyte differentiation [UNKNOWN][IEA]
    response to antibiotic [IEP]
    regulation of receptor-mediated endocytosis [IMP]
    protein amino acid phosphorylation [UNKNOWN][IEA]
    negative regulation of protein kinase activity [UNKNOWN][IEA]
    response to toxin [IEP]
    learning or memory [IMP]
    response to mechanical stimulus [IEP]
    negative regulation of heart contraction [IMP]
    positive regulation of exocytosis [IMP]
    inactivation of MAPK activity [UNKNOWN][IEA]
    positive regulation of smooth muscle cell proliferation [IMP]
    response to ethanol [IMP]
    regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA]
    regulation of muscle contraction [UNKNOWN][IEA]
    positive regulation of synaptogenesis [IMP]
    negative regulation of translation [IMP]
    induction of positive chemotaxis [UNKNOWN][IEA]
    positive regulation of inflammatory response [UNKNOWN][IEA]
    negative regulation of glucose import [UNKNOWN][IEA]
    response to organic cyclic substance [IEP]
    response to reactive oxygen species [IMP]
    aging [IEP]
    response to peptide hormone stimulus [IEP]
    negative regulation of insulin receptor signaling pathway [UNKNOWN][IEA]
    cellular calcium ion homeostasis [UNKNOWN][IEA]
    regulation of the force of heart contraction [UNKNOWN][IEA]
    induction of apoptosis by intracellular signals [UNKNOWN][IEA]
    establishment of protein localization [TAS]
    response to corticosterone stimulus [IEP]
    intracellular signaling pathway [IDA]
    histone H3-T6 phosphorylation [UNKNOWN]
    negative regulation of protein amino acid phosphorylation [UNKNOWN][IEA]
    positive regulation of protein amino acid phosphorylation [UNKNOWN][IEA]
    response to estradiol stimulus [IMP]
    response to interleukin-1 [UNKNOWN][IEA]
    neutrophil chemotaxis [UNKNOWN][IEA]
    peptidyl-serine phosphorylation [IDA]
    peptidyl-threonine phosphorylation [IDA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    zinc ion binding [IEA]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    protein serine/threonine kinase activity [UNKNOWN]
    transferase activity [IEA]
    calcium-dependent protein kinase C activity [UNKNOWN][IDA]
    protein kinase C activity [UNKNOWN][IDA][IEA]
    histone kinase activity (H3-T6 specific) [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADVYPANDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF  60
   61 GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
  121 LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVTD EKLHVTVRDA 180
  181 KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
  241 SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNVE 300
  301 LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360
  361 TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420
  421 NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480
  481 DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG 540
  541 EDEDELFQSI MEHNVSYPKS LSKEAVSICK GLMTKHPAKR LGCGPEGERD VREHAFFRRI 600
  601 DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN 660
  661 PQFVHPILQS AV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle