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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. Any process that modulates the frequency, rate or extent of a signaling pathway. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling. Any process that modulates the frequency, rate or extent of insulin receptor signaling. Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of insulin receptor signaling pathway
Acc: GO:0046627
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling.
Synonyms:
  • down-regulation of insulin receptor signaling pathway
  • inhibition of insulin receptor signaling pathway
  • negative regulation of insulin receptor signalling pathway
  • downregulation of insulin receptor signaling pathway
  • down regulation of insulin receptor signaling pathway
Proteins in PDR annotated with:
   This term: 46 [Search]
   Term or descendants: 46 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046627 - negative regulation of insulin receptor signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle