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Any process that stops, prevents or reduces the frequency or rate of heart contraction. The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body. Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body. Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. Any biological process, occurring at the level of a multicellular organism, pertinent to its function. Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure. Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: negative regulation of heart contraction
Acc: GO:0045822
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction.
Synonyms:
  • downregulation of heart contraction
  • down regulation of heart contraction
  • negative regulation of cardiac contraction
  • inhibition of heart contraction
  • down-regulation of heart contraction
Proteins in PDR annotated with:
   This term: 22 [Search]
   Term or descendants: 30 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045822 - negative regulation of heart contraction (interactive image map)

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