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Protein Overview: SET1

General Information:
Name(s) found: SET1 / YHR119W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1080 amino acids

    Gene Ontology:
    Cellular Component: Set1C/COMPASS complex [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    chromatin silencing at rDNA [TASLink to PubMed article]
    histone methylation [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    peptidyl-lysine dimethylation [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: histone methyltransferase activity (H3-K4 specific) [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    histone methyltransferase activity [ISSLink to PubMed article]
    protein-lysine N-methyltransferase activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNYYRRAHA SSGSYRQPQE QPQYSRSGHY QYSNGHSHQQ YSSQYNQRRR YNHNDGTRRR  60
   61 YNDDRPHSSN NASTRQYYAT NNSQSGPYVN KKSDISSRRG MSQSRYSNSN VHNTLASSSG 120
  121 SLPTESALLL QQRPPSVLRY NTDNLKSKFH YFDPIKGEFF NKDKMLSWKA TDKEFSETGY 180
  181 YVVKELQDGQ FKFKIKHRHP EIKASDPRNE NGIMTSGKVA THRKCRNSLI LLPRISYDRY 240
  241 SLGPPPSCEI VVYPAQDSTT TNIQDISIKN YFKKYGEISH FEAFNDPNSA LPLHVYLIKY 300
  301 ASSDGKINDA AKAAFSAVRK HESSGCFIMG FKFEVILNKH SILNNIISKF VEINVKKLQK 360
  361 LQENLKKAKE KEAENEKAKE LQGKDITLPK EPKVDTLSHS SGSEKRIPYD LLGVVNNRPV 420
  421 LHVSKIFVAK HRFCVEDFKY KLRGYRCAKF IDHPTGIYII FNDIAHAQTC SNAESGNLTI 480
  481 MSRSRRIPIL IKFHLILPRF QNRTRFNKSS SSSNSTNVPI KYESKEEFIE ATAKQILKDL 540
  541 EKTLHVDIKK RLIGPTVFDA LDHANFPELL AKRELKEKEK RQQIASKIAE DELKRKEEAK 600
  601 RDFDLFGLYG GYAKSNKRNL KRHNSLALDH TSLKRKKLSN GIKPMAHLLN EETDSKETTP 660
  661 LNDEGITRVS KEHDEEDENM TSSSSEEEEE EAPDKKFKSE SEPTTPESDH LHGIKPLVPD 720
  721 QNGSSDVLDA SSMYKPTATE IPEPVYPPEE YDLKYSQTLS SMDLQNAIKD EEDMLILKQL 780
  781 LSTYTPTVTP ETSAALEYKI WQSRRKVLEE EKASDWQIEL NGTLFDSELQ PGSSFKAEGF 840
  841 RKIADKLKIN YLPHRRRVHQ PLNTVNIHNE RNEYTPELCQ REESSNKEPS DSVPQEVSSS 900
  901 RDNRASNRRF QQDIEAQKAA IGTESELLSL NQLNKRKKPV MFARSAIHNW GLYALDSIAA 960
  961 KEMIIEYVGE RIRQPVAEMR EKRYLKNGIG SSYLFRVDEN TVIDATKKGG IARFINHCCD1020
 1021 PNCTAKIIKV GGRRRIVIYA LRDIAASEEL TYDYKFEREK DDEERLPCLC GAPNCKGFLN1080
 1081

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRE2 SDC1 SET1 SHG1 SPP1 SWD1 SWD2 SWD3
    View Details Krogan NJ, et al. (2006) BRE2 ERF2 SDC1 SET1 SHG1 SPP1 SWD1 SWD3 YHI9 YLL023C
    View Details Gavin AC, et al. (2006) BRE2 SDC1 SET1 SPP1 SWD1 SWD3
    View Details Gavin AC, et al. (2002) BRE2 DOA4 RSM7 SDC1 SET1 SPP1 SSZ1 SWD1 SWD3
    View Details Ho Y, et al. (2002) BRE2 HPR1 PSK2 RPN1 SET1 SFP1 SGS1 SUV3 SWD3
    View Details Qiu et al. (2008) BRE2 SDC1 SET1 SPP1 SWD1 SWD2 SWD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen VPS5 SET1 2 Unpublished Fields Lab Data
    View Screen CNB1 SET1 1 Unpublished Fields Lab Data
    View Screen UBC7 SET1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SET1 Huh WK, et al. (2003)
    View Data SET1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..286] deduced N/A No confident structure predictions are available.
    2 View Details [287..807] MSA 22.272997 View MSA. No confident structure predictions are available.
    3 View Details [808..901] deduced N/A No confident structure predictions are available.
    4 View Details [902..1080] Pfam 62.69897 SET domain No confident structure predictions are available.
    5 View Details [734..809] deduced N/A No confident structure predictions are available.
    6 View Details [810..1080] PSI-BLAST 61.69897 No description for 2r3aA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  4.65259034341669 bayes_pls_golite062009
  • binding
    		•  3.48033873254013 bayes_pls_golite062009
  • RNA binding
    		•  2.51560202858525 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.47873883381637 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.2045206027152 bayes_pls_golite062009
  • DNA binding
    		•  1.99030664201171 bayes_pls_golite062009
  • mRNA binding
    		•  1.52376515340629 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.26023364760328 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.19033433766236 bayes_pls_golite062009
  • transcription factor activity
    		•  1.09958329302628 bayes_pls_golite062009
  • protein binding
    		•  1.05805521997665 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.866729044067453 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.715114913338408 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.633093884585572 bayes_pls_golite062009
    		• 0.612296958107081 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.327072171076297 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle