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View Structure Prediction Details

Protein: SET1
Organism: Saccharomyces cerevisiae
Length: 1080 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SET1.

Description E-value Query
Range
Subject
Range
gi|190405898 - gi|190405898|gb|EDV09165.1| histone-lysine N-methyltransferase [Saccharomyces cerevisiae RM11-1a]
SET1_YEAST - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Saccharomyces cerevisiae (strain ATCC 20...
SET1 - Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lys...
0.0 [1..1080] [1..1080]
SET1_SCHPO - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Schizosaccharomyces pombe (strain 972 / ...
set1 - histone lysine methyltransferase Set1
0.0 [200..1080] [47..920]
ash1-PA - The gene absent, small, or homeotic discs 1 is referred to in FlyBase by the symbol Dmel\ash1 (CG888...
1.0E-72 [272..1079] [752..1520]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-72 [272..1079] [679..1447]
gi|168267342, gi... - gi|61361080|gb|AAX41986.1| enhancer of zeste-like 1 [synthetic construct], gi|168267342|dbj|BAG09727...
EZH1 - enhancer of zeste homolog 1 (Drosophila)
gi|114667137, gi... - gi|114667139|ref|XP_511519.2| PREDICTED: enhancer of zeste homolog 1 isoform 7 [Pan troglodytes], gi...
2.0E-71 [523..1060] [188..733]
EZH1_MOUSE - Histone-lysine N-methyltransferase EZH1 OS=Mus musculus GN=Ezh1 PE=1 SV=1
5.0E-70 [524..1060] [188..733]

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Predicted Domain #1
Region A:
Residues: [1-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNYYRRAHA SSGSYRQPQE QPQYSRSGHY QYSNGHSHQQ YSSQYNQRRR YNHNDGTRRR  60
   61 YNDDRPHSSN NASTRQYYAT NNSQSGPYVN KKSDISSRRG MSQSRYSNSN VHNTLASSSG 120
  121 SLPTESALLL QQRPPSVLRY NTDNLKSKFH YFDPIKGEFF NKDKMLSWKA TDKEFSETGY 180
  181 YVVKELQDGQ FKFKIKHRHP EIKASDPRNE NGIMTSGKVA THRKCRNSLI LLPRISYDRY 240
  241 SLGPPPSCEI VVYPAQDSTT TNIQDISIKN YFKKYGEISH FEAFND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [287-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNSALPLHVY LIKYASSDGK INDAAKAAFS AVRKHESSGC FIMGFKFEVI LNKHSILNNI  60
   61 ISKFVEINVK KLQKLQENLK KAKEKEAENE KAKELQGKDI TLPKEPKVDT LSHSSGSEKR 120
  121 IPYDLLGVVN NRPVLHVSKI FVAKHRFCVE DFKYKLRGYR CAKFIDHPTG IYIIFNDIAH 180
  181 AQTCSNAESG NLTIMSRSRR IPILIKFHLI LPRFQNRTRF NKSSSSSNST NVPIKYESKE 240
  241 EFIEATAKQI LKDLEKTLHV DIKKRLIGPT VFDALDHANF PELLAKRELK EKEKRQQIAS 300
  301 KIAEDELKRK EEAKRDFDLF GLYGGYAKSN KRNLKRHNSL ALDHTSLKRK KLSNGIKPMA 360
  361 HLLNEETDSK ETTPLNDEGI TRVSKEHDEE DENMTSSSSE EEEEEAPDKK FKSESEPTTP 420
  421 ESDHLHGIKP LVPDQNGSSD VLDASSMYKP TATEIPEPVY PPEEYDLKYS QTLSSMDLQN 480
  481 AIKDEEDMLI LKQLLSTYTP TVTPETSAAL EYKIWQSRRK V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [808-901]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEEEKASDWQ IELNGTLFDS ELQPGSSFKA EGFRKIADKL KINYLPHRRR VHQPLNTVNI  60
   61 HNERNEYTPE LCQREESSNK EPSDSVPQEV SSSR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.65259034341669 bayes_pls_golite062009
binding 3.48033873254013 bayes_pls_golite062009
RNA binding 2.51560202858525 bayes_pls_golite062009
telomeric DNA binding 2.47873883381637 bayes_pls_golite062009
transcription regulator activity 2.2045206027152 bayes_pls_golite062009
DNA binding 1.99030664201171 bayes_pls_golite062009
mRNA binding 1.52376515340629 bayes_pls_golite062009
transcription repressor activity 1.26023364760328 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.19033433766236 bayes_pls_golite062009
transcription factor activity 1.09958329302628 bayes_pls_golite062009
protein binding 1.05805521997665 bayes_pls_golite062009
structure-specific DNA binding 0.866729044067453 bayes_pls_golite062009
single-stranded DNA binding 0.715114913338408 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.633093884585572 bayes_pls_golite062009
0.612296958107081 bayes_pls_golite062009
sequence-specific DNA binding 0.327072171076297 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [902-1080]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNRASNRRFQ QDIEAQKAAI GTESELLSLN QLNKRKKPVM FARSAIHNWG LYALDSIAAK  60
   61 EMIIEYVGER IRQPVAEMRE KRYLKNGIGS SYLFRVDENT VIDATKKGGI ARFINHCCDP 120
  121 NCTAKIIKVG GRRRIVIYAL RDIAASEELT YDYKFEREKD DEERLPCLCG APNCKGFLN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 62.69897
Match: PF00856
Description: SET domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [734-809]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKPTATEIPE PVYPPEEYDL KYSQTLSSMD LQNAIKDEED MLILKQLLST YTPTVTPETS  60
   61 AALEYKIWQS RRKVLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [810-1080]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEKASDWQIE LNGTLFDSEL QPGSSFKAEG FRKIADKLKI NYLPHRRRVH QPLNTVNIHN  60
   61 ERNEYTPELC QREESSNKEP SDSVPQEVSS SRDNRASNRR FQQDIEAQKA AIGTESELLS 120
  121 LNQLNKRKKP VMFARSAIHN WGLYALDSIA AKEMIIEYVG ERIRQPVAEM REKRYLKNGI 180
  181 GSSYLFRVDE NTVIDATKKG GIARFINHCC DPNCTAKIIK VGGRRRIVIY ALRDIAASEE 240
  241 LTYDYKFERE KDDEERLPCL CGAPNCKGFL N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.69897
Match: 2r3aA
Description: No description for 2r3aA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle