YRC Public Data Repository - Protein Structure Prediction

Protein:	SET1
Organism:	Saccharomyces cerevisiae
Length:	1080 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SET1.

Description	E-value	Query Range	Subject Range
gi\|190405898 - gi\|190405898\|gb\|EDV09165.1\| histone-lysine N-methyltransferase [Saccharomyces cerevisiae RM11-1a] SET1_YEAST - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Saccharomyces cerevisiae (strain ATCC 20... SET1 - Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lys...	0.0	[1..1080]	[1..1080]
SET1_SCHPO - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Schizosaccharomyces pombe (strain 972 / ... set1 - histone lysine methyltransferase Set1	0.0	[200..1080]	[47..920]
ash1-PA - The gene absent, small, or homeotic discs 1 is referred to in FlyBase by the symbol Dmel\ash1 (CG888...	1.0E-72	[272..1079]	[752..1520]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-72	[272..1079]	[679..1447]
gi\|168267342, gi... - gi\|61361080\|gb\|AAX41986.1\| enhancer of zeste-like 1 [synthetic construct], gi\|168267342\|dbj\|BAG09727... EZH1 - enhancer of zeste homolog 1 (Drosophila) gi\|114667137, gi... - gi\|114667139\|ref\|XP_511519.2\| PREDICTED: enhancer of zeste homolog 1 isoform 7 [Pan troglodytes], gi...	2.0E-71	[523..1060]	[188..733]
EZH1_MOUSE - Histone-lysine N-methyltransferase EZH1 OS=Mus musculus GN=Ezh1 PE=1 SV=1	5.0E-70	[524..1060]	[188..733]

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Predicted Domain #1

Region A:
Residues: [1-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNYYRRAHA SSGSYRQPQE QPQYSRSGHY QYSNGHSHQQ YSSQYNQRRR YNHNDGTRRR  60
   61 YNDDRPHSSN NASTRQYYAT NNSQSGPYVN KKSDISSRRG MSQSRYSNSN VHNTLASSSG 120
  121 SLPTESALLL QQRPPSVLRY NTDNLKSKFH YFDPIKGEFF NKDKMLSWKA TDKEFSETGY 180
  181 YVVKELQDGQ FKFKIKHRHP EIKASDPRNE NGIMTSGKVA THRKCRNSLI LLPRISYDRY 240
  241 SLGPPPSCEI VVYPAQDSTT TNIQDISIKN YFKKYGEISH FEAFND

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [287-807]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNSALPLHVY LIKYASSDGK INDAAKAAFS AVRKHESSGC FIMGFKFEVI LNKHSILNNI  60
   61 ISKFVEINVK KLQKLQENLK KAKEKEAENE KAKELQGKDI TLPKEPKVDT LSHSSGSEKR 120
  121 IPYDLLGVVN NRPVLHVSKI FVAKHRFCVE DFKYKLRGYR CAKFIDHPTG IYIIFNDIAH 180
  181 AQTCSNAESG NLTIMSRSRR IPILIKFHLI LPRFQNRTRF NKSSSSSNST NVPIKYESKE 240
  241 EFIEATAKQI LKDLEKTLHV DIKKRLIGPT VFDALDHANF PELLAKRELK EKEKRQQIAS 300
  301 KIAEDELKRK EEAKRDFDLF GLYGGYAKSN KRNLKRHNSL ALDHTSLKRK KLSNGIKPMA 360
  361 HLLNEETDSK ETTPLNDEGI TRVSKEHDEE DENMTSSSSE EEEEEAPDKK FKSESEPTTP 420
  421 ESDHLHGIKP LVPDQNGSSD VLDASSMYKP TATEIPEPVY PPEEYDLKYS QTLSSMDLQN 480
  481 AIKDEEDMLI LKQLLSTYTP TVTPETSAAL EYKIWQSRRK V

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [808-901]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEEEKASDWQ IELNGTLFDS ELQPGSSFKA EGFRKIADKL KINYLPHRRR VHQPLNTVNI  60
   61 HNERNEYTPE LCQREESSNK EPSDSVPQEV SSSR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.735	a.28.1	ACP-like
View	Download	0.358	a.22.1	Histone-fold
View	Download	0.363	a.64.1	Saposin
View	Download	0.638	c.102.1	Cell-division inhibitor MinC, N-terminal domain
View	Download	0.409	a.23.1	HSC20 (HSCB), C-terminal oligomerisation domain
View	Download	0.352	a.7.6	Ribosomal protein S20
View	Download	0.349	a.13.1	alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View	Download	0.334	d.43.1	Elongation factor Ts (EF-Ts), dimerisation domain
View	Download	0.320	a.58.1	Chemotaxis receptor methyltransferase CheR, N-terminal domain
View	Download	0.314	d.15.1	Ubiquitin-like
View	Download	0.309	a.39.1	EF-hand
View	Download	0.291	d.29.1	Ribosomal protein L31e
View	Download	0.286	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.283	a.4.2	Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View	Download	0.270	d.188.1	Prokaryotic ribosomal protein L17
View	Download	0.262	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.245	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.226	a.28.1	ACP-like
View	Download	0.209	b.84.2	Rudiment single hybrid motif

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	4.65259034341669	bayes_pls_golite062009
binding	3.48033873254013	bayes_pls_golite062009
RNA binding	2.51560202858525	bayes_pls_golite062009
telomeric DNA binding	2.47873883381637	bayes_pls_golite062009
transcription regulator activity	2.2045206027152	bayes_pls_golite062009
DNA binding	1.99030664201171	bayes_pls_golite062009
mRNA binding	1.52376515340629	bayes_pls_golite062009
transcription repressor activity	1.26023364760328	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.19033433766236	bayes_pls_golite062009
transcription factor activity	1.09958329302628	bayes_pls_golite062009
protein binding	1.05805521997665	bayes_pls_golite062009
structure-specific DNA binding	0.866729044067453	bayes_pls_golite062009
single-stranded DNA binding	0.715114913338408	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.633093884585572	bayes_pls_golite062009
	0.612296958107081	bayes_pls_golite062009
sequence-specific DNA binding	0.327072171076297	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [902-1080]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNRASNRRFQ QDIEAQKAAI GTESELLSLN QLNKRKKPVM FARSAIHNWG LYALDSIAAK  60
   61 EMIIEYVGER IRQPVAEMRE KRYLKNGIGS SYLFRVDENT VIDATKKGGI ARFINHCCDP 120
  121 NCTAKIIKVG GRRRIVIYAL RDIAASEELT YDYKFEREKD DEERLPCLCG APNCKGFLN

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	62.69897
Match:	PF00856
Description:	SET domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [734-809]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKPTATEIPE PVYPPEEYDL KYSQTLSSMD LQNAIKDEED MLILKQLLST YTPTVTPETS  60
   61 AALEYKIWQS RRKVLE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [810-1080]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEKASDWQIE LNGTLFDSEL QPGSSFKAEG FRKIADKLKI NYLPHRRRVH QPLNTVNIHN  60
   61 ERNEYTPELC QREESSNKEP SDSVPQEVSS SRDNRASNRR FQQDIEAQKA AIGTESELLS 120
  121 LNQLNKRKKP VMFARSAIHN WGLYALDSIA AKEMIIEYVG ERIRQPVAEM REKRYLKNGI 180
  181 GSSYLFRVDE NTVIDATKKG GIARFINHCC DPNCTAKIIK VGGRRRIVIY ALRDIAASEE 240
  241 LTYDYKFERE KDDEERLPCL CGAPNCKGFL N

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.69897
Match:	2r3aA
Description:	No description for 2r3aA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: