Protein Overview: HOS2

General Information:
Name(s) found:	HOS2 / YGL194C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321244\|ref\|NP_011321.1\| Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylas [NCBI NR] pir\|\|S64211 probable transcription regulator YGL194c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1723948\|sp\|P53096.1\|HOS2_YEAST RecName: Full=Probable histone deacetylase HOS2 [NCBI NR] gi\|1322819\|emb\|CAA96906.1\| RTL1 [Saccharomyces cerevisiae] [NCBI NR] Probable histone deacetylase HOS2 OS=Saccharomyces cerevisiae GN=HOS2 PE=1 SV=1 [Swiss-Prot] HOS2 Putative histone deacetylase [mips] Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity [SGD] HOS2, Chr VII from 140372-141730, reverse complement [yeast_orfs2] Chr VII from 140372-141730, reverse complement [yeastorf3.fasta] Chr VII from 141730-140372, reverse complement [yeastorf5.fasta] (P53096) Probable histone deacetylase HOS2 [4932.FASTACCERV.txt] HOS2 SGDID:S0003162, Chr VII from 141730-140372, reverse complement, Verified ORF [yeastflysequest.fasta] HOS2 SGDID:S0003162, Chr VII from 141732-140374, reverse complement, Verified ORF [10112005cervSGD.fasta] Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity [Saccharomyces ce [nrdb_11152004_Chlamydomonas] HOS2 SGDID:S000003162, Chr VII from 141732-140374, reverse complement, Verified ORF, "Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repres [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; Hos2p [Saccharom [nr-271106-contam.fasta] Probable histone deacetylase HOS2 [nr-271106-contam.fasta] RTL1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] HOS2 SGDID:S000003162, Chr VII from 141732-140374, reverse complement, Verified ORF, "Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Probable histone deacetylase HOS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOS2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HOS2 SGDID:S000003162, Chr VII from 141726-140368, Genome Release 64-1-1, reverse complement, Verified ORF, "Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity" [yeast-030211-contam.fasta] HOS2 SGDID:S000003162, Chr VII from 141726-140368, Genome Release 64-2-1, reverse complement, Verified ORF, "Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS" [20141208_orf_trans.fasta] TR486\|c0_g1_i1\|g.260 ORF TR486\|c0_g1_i1\|g.260 TR486\|c0_g1_i1\|m.260 type:complete len:453 (+) TR486\|c0_g1_i1:85-1443(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR3326\|c0_g1_i1\|g.2154 ORF TR3326\|c0_g1_i1\|g.2154 TR3326\|c0_g1_i1\|m.2154 type:complete len:453 (+) TR3326\|c0_g1_i1:89-1447(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YGL194C SGDID:S000003162, Chr VII from 141726-140368, Genome Release 64-1-1, reverse complement, Verified ORF, "Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_2109\|g.1558 ORF asmbl_2109\|g.1558 asmbl_2109\|m.1558 type:complete len:453 (+) asmbl_2109:81-1439(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_2031\|g.1275 ORF ID=asmbl_2031\|g.1275 ID=asmbl_2031\|m.1275 type:complete len:453 (+) ID=asmbl_2031:2497-3855(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_2113\|g.1257 ORF ID=asmbl_2113\|g.1257 ID=asmbl_2113\|m.1257 type:complete len:453 (+) ID=asmbl_2113:81-1439(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	452 amino acids
Gene Ontology:
Cellular Component:	histone deacetylase complex [IPI][TAS]
Biological Process:	regulation of transcription, DNA-dependent [ISS ] chromatin organization [ISS ] histone deacetylation [IDA][IPI] negative regulation of meiosis [IMP]
Molecular Function:	NAD-dependent histone deacetylase activity [IDA][IPI] NAD-independent histone deacetylase activity [IDA][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF RLMLTDHLVS  60
   61 SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN ANKLPRGTLE NFNIGDDCPI 120
  121 FQNLYDYTTL YTGASLDATR KLINNQSDIA INWSGGLHHA KKNSPSGFCY VNDIVLSILN 180
  181 LLRYHPRILY IDIDLHHGDG VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH 240
  241 FALNVPLEDG IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH 300
  301 GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED IPFRDSFGPD 360
  361 YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV RMDAECIPTQ DISALTEEED 420
  421 KIIQEMNEET EADSSNRLEE MEKENSGLIA FS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CPR1 HOS2 HOS4 SET3 SIF2 SNT1
View Details	Gavin AC, et al. (2006)		CPR1 HOS2 HOS4 SET3 SIF2 SNT1
View Details	Gavin AC, et al. (2002)		BLM10 CDC55 CIN1 CPR1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 RVB2 SCL1 SET3 SIF2 SNF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
View Details	Qiu et al. (2008)		HOS2 HOS4 SDS3 SET3 SIF2 SNT1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPT21	HOS2	1	Unpublished Fields Lab Data
View Screen	NAF1	HOS2	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HOS2	Huh WK, et al. (2003)
View Data	HOS2 and NOP56	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..185]	PSI-BLAST	518.218487	HDAC homologue
2	View Details	[186..370]	PSI-BLAST	518.218487	HDAC homologue
3	View Details	[371..452]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
protein deacetylase activity	12.8220438463909	bayes_pls_golite062009
histone deacetylase activity	12.6231784270509	bayes_pls_golite062009
deacetylase activity	11.5037545953213	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	9.39837596691907	bayes_pls_golite062009
histone deacetylase activity (H3-K16 specific)	6.99181745976945	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	5.91624581343504	bayes_pls_golite062009
agmatinase activity	3.73238467801147	bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific)	3.65015413158247	bayes_pls_golite062009
transcription repressor activity	3.49362347258099	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	3.35999169984456	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	3.35999169984456	bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific)	3.25708078682827	bayes_pls_golite062009
transcription regulator activity	3.05701986980927	bayes_pls_golite062009
histone methyltransferase activity (H3-K27 specific)	2.60243126690148	bayes_pls_golite062009
hydrolase activity	2.48411098726406	bayes_pls_golite062009
transcription factor binding	2.19991964087943	bayes_pls_golite062009
NAD-independent histone deacetylase activity	2.1026758793482	bayes_pls_golite062009
nucleic acid binding	2.09632179671955	bayes_pls_golite062009
transcription corepressor activity	1.98907367314887	bayes_pls_golite062009
DNA binding	1.982290944939	bayes_pls_golite062009
binding	1.948738669065	bayes_pls_golite062009
protein binding	1.77599011146146	bayes_pls_golite062009
catalytic activity	1.68836803454021	bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific)	1.48241147541212	bayes_pls_golite062009
specific transcriptional repressor activity	1.37118634909958	bayes_pls_golite062009
arginase activity	1.34373529002692	bayes_pls_golite062009
transcription activator activity	1.31578100431097	bayes_pls_golite062009
transcription factor activity	1.24596588472933	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1.01223037319069	bayes_pls_golite062009
transcription cofactor activity	0.84972377395539	bayes_pls_golite062009
histone methyltransferase activity	0.396822865624511	bayes_pls_golite062009
transferase activity	0.323230424038105	bayes_pls_golite062009
chromatin binding	0.104097933861351	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2