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View Structure Prediction Details

Protein: HOS2
Organism: Saccharomyces cerevisiae
Length: 452 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOS2.

Description E-value Query
Range		 Subject
Range
HOS2_YEAST - Probable histone deacetylase HOS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOS2 P...
HOS2 - Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 ...
gi|151943623 - gi|151943623|gb|EDN61933.1| conserved protein [Saccharomyces cerevisiae YJM789]
 0.0 [1..452] [1..452]
HDAC1_CHICK - Histone deacetylase 1 OS=Gallus gallus GN=HDAC1 PE=2 SV=1
 0.0 [25..447] [8..429]
HDA1B_XENLA - Probable histone deacetylase 1-B OS=Xenopus laevis GN=hdac1-b PE=1 SV=1
 0.0 [25..447] [8..429]
HDAC1_MOUSE - Histone deacetylase 1 OS=Mus musculus GN=Hdac1 PE=1 SV=1
 0.0 [25..447] [8..429]
gi|3659524 - gi|3659524|gb|AAC61494.1| putative histone deacetylase [Drosophila melanogaster]
 0.0 [25..447] [6..427]
HDAC1_PONPY - Histone deacetylase 1 - Pongo pygmaeus (Orangutan)
HDAC1 - histone deacetylase 1
gi|123995803, gi... - gi|61363144|gb|AAX42342.1| histone deacetylase 1 [synthetic construct], gi|60814459|gb|AAX36302.1| h...
HDAC1_PONAB - Histone deacetylase 1 OS=Pongo abelii GN=HDAC1 PE=2 SV=1
 0.0 [26..434] [9..416]

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Predicted Domain #1
Region A:
Residues: [1-185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF RLMLTDHLVS  60
   61 SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN ANKLPRGTLE NFNIGDDCPI 120
  121 FQNLYDYTTL YTGASLDATR KLINNQSDIA INWSGGLHHA KKNSPSGFCY VNDIVLSILN 180
  181 LLRYH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 518.218487
Match: 1c3pA_
Description: HDAC homologue
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 12.8220438463909 bayes_pls_golite062009
histone deacetylase activity 12.6231784270509 bayes_pls_golite062009
deacetylase activity 11.5037545953213 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9.39837596691907 bayes_pls_golite062009
histone deacetylase activity (H3-K16 specific) 6.99181745976945 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5.91624581343504 bayes_pls_golite062009
agmatinase activity 3.73238467801147 bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific) 3.65015413158247 bayes_pls_golite062009
transcription repressor activity 3.49362347258099 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 3.35999169984456 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 3.35999169984456 bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific) 3.25708078682827 bayes_pls_golite062009
transcription regulator activity 3.05701986980927 bayes_pls_golite062009
histone methyltransferase activity (H3-K27 specific) 2.60243126690148 bayes_pls_golite062009
hydrolase activity 2.48411098726406 bayes_pls_golite062009
transcription factor binding 2.19991964087943 bayes_pls_golite062009
NAD-independent histone deacetylase activity 2.1026758793482 bayes_pls_golite062009
nucleic acid binding 2.09632179671955 bayes_pls_golite062009
transcription corepressor activity 1.98907367314887 bayes_pls_golite062009
DNA binding 1.982290944939 bayes_pls_golite062009
binding 1.948738669065 bayes_pls_golite062009
protein binding 1.77599011146146 bayes_pls_golite062009
catalytic activity 1.68836803454021 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 1.48241147541212 bayes_pls_golite062009
specific transcriptional repressor activity 1.37118634909958 bayes_pls_golite062009
arginase activity 1.34373529002692 bayes_pls_golite062009
transcription activator activity 1.31578100431097 bayes_pls_golite062009
transcription factor activity 1.24596588472933 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1.01223037319069 bayes_pls_golite062009
transcription cofactor activity 0.84972377395539 bayes_pls_golite062009
histone methyltransferase activity 0.396822865624511 bayes_pls_golite062009
transferase activity 0.323230424038105 bayes_pls_golite062009
chromatin binding 0.104097933861351 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-370] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRILYIDIDL HHGDGVQEAF YTTDRVFTLS FHKYNGEFFP GTGDLTEIGC DKGKHFALNV  60
   61 PLEDGIDDDS YINLFKSIVD PLIMTFKPTL IVQQCGADSL GHDRLGCFNL NIKAHGECVK 120
  121 FVKSFGLPML VVGGGGYTPR NVSRLWTYET GILNDVLLPE DIPEDIPFRD SFGPDYSLYP 180
  181 MLDDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 518.218487
Match: 1c3pA_
Description: HDAC homologue
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [371-452] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YENKNSKKLL EDIRIRCLEN IRYLQGAPSV RMDAECIPTQ DISALTEEED KIIQEMNEET  60
   61 EADSSNRLEE MEKENSGLIA FS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle