Protein Overview: RSM23

General Information:
Name(s) found:	RSM23 / YGL129C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321309\|ref\|NP_011386.1\| Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p; Rsm23p [Saccharomyces cerevisi [NCBI NR] pir\|\|S64140 hypothetical protein YGL129c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1723915\|sp\|Q01163.2\|RT23_YEAST RecName: Full=37S ribosomal protein S23, mitochondrial; AltName: Full=DAP-3; Flags: Precursor [NCBI NR] gi\|1322695\|emb\|CAA96838.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1246908\|emb\|CAA60702.1\| G2856 [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YGL129C - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot] 37S ribosomal protein S23, mitochondrial OS=Saccharomyces cerevisiae GN=RSM23 PE=1 SV=2 [Swiss-Prot] RSM23 Mitochondrial ribosomal protein, small subunit [mips] Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p [SGD] RSM23, Chr VII from 267726-269192, reverse complement [yeast_orfs2] Chr VII from 267726-269192, reverse complement [yeastorf3.fasta] Chr VII from 269192-267726, reverse complement [yeastorf5.fasta] (Q01163) Hypothetical 55.6 kDa protein in CEG1-SOH1 intergenic region [4932.FASTACCERV.txt] RSM23 SGDID:S0003097, Chr VII from 269192-267726, reverse complement, Verified ORF [yeastflysequest.fasta] RSM23 SGDID:S0003097, Chr VII from 269194-267728, reverse complement, Verified ORF [10112005cervSGD.fasta] Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p [Saccharomyces cerevisiae]gi\|1322695\|emb\|CAA96838.1\| unnam [nrdb_11152004_Chlamydomonas] RSM23 SGDID:S000003097, Chr VII from 269194-267728, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overprod [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Uncharacterized protein YGL129C [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] G2856 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p; Rsm23p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] RSM23 SGDID:S000003097, Chr VII from 269194-267728, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	488 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial small ribosomal subunit [IDA]
Biological Process:	response to drug [IMP] translation [IDA]
Molecular Function:	structural constituent of ribosome [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYKNIYICIL YIYINFYTSR ENINKRTSTS HVVIRIRIML RMSTSRFIGQ RLFTTARSLQ  60
   61 AAKPAPKGKT QGFSKKSSSV SSYSSAKRVT PGSLYKNWTN TTHTAQLQQT AVPLALPIFN 120
  121 FDDISKTLNK VVSYSNKQYK SLHHLGSFKK SQFNELFQKP VCLVREDATN SFLKKLVSHP 180
  181 VKKFIITGEP GVGKTVLLSQ AHAYAVDSKQ IIINISYPEL FLNGRNDFSY DDDLKLFIQP 240
  241 MYLKKLIRKI LKANDPALLK SIELSKDYKF SNANPKNASV KPFVTLNKTK NTVLDLLSVM 300
  301 THPHNRGKLM KAIIDELSVQ SKVPIMFTVD NFSKVLTTAY SAYRNTENKQ IYSLDLQMGK 360
  361 LMMDIISGET KFANGESSTI LAISGVDRTN KTLPVALGKI PVDPYVTRYH YEPKFVELLQ 420
  421 KGNVTEFEVP KLNKQEVNEL IDYYKQSNVL LDKDITGKKW ENLIDEKYFL SGNGNPRELL 480
  481 KSLVLSHR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		EHD3 MRP1 MRP10 MRP13 MRP17 MRP21 MRP4 MRP51 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS8 MRPS9 NAM9 PET123 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 SWS2
View Details	Hazbun TR, et al. (2003)		RSM23 TTI2
View Details	(MIPS) Mewes HW, et al. (2004)		MRP1 MRP10 MRP13 MRP17 MRP2 MRP21 MRP4 MRP51 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS8 MRPS9 NAM9 PET123 PPE1 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 VAR1 YMR31
View Details	Krogan NJ, et al. (2006)		CBF1 FYV4 MAM33 MRP1 MRP10 MRP17 MRP21 MRP4 MRP51 MRPL8 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS9 NAM9 NCL1 PET123 RIB4 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM28 RSM7 SVL3 SWS2 YDR124W YJR096W YKL151C YSP1
View Details	Gavin AC, et al. (2006)		ADE6 EHD3 MRP1 MRP13 MRP17 MRP21 MRP4 MRP51 MRPS16 MRPS17 MRPS18 MRPS28 MRPS5 MRPS8 MRPS9 NAM9 PET123 RSM10 RSM19 RSM22 RSM23 RSM25 RSM27 RSM7
View Details	Gavin AC, et al. (2002)		BEM2 CCM1 ECM16 EHD3 FYV4 GEP3 HSC82 MRP1 MRP10 MRP13 MRP17 MRP21 MRP4 MRP51 MRPS16 MRPS17 MRPS18 MRPS28 MRPS5 MRPS8 MRPS9 NAM9 PAP2 PET123 PSD2 PUS7 RIX1 RSM10 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 TIF4631 UBP10 UTP20 UTP22
View Details	Qiu et al. (2008)		EHD3 IMG1 MAM33 MNP1 MRP1 MRP10 MRP13 MRP17 MRP2 MRP20 MRP21 MRP4 MRP51 MRP7 MRPL1 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL25 MRPL27 MRPL3 MRPL31 MRPL32 MRPL35 MRPL36 MRPL39 MRPL49 MRPL50 MRPL8 MRPL9 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS8 MRPS9 NAM9 PET123 PPE1 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM28 RSM7 SWS2 VAR1 YML6 YMR31

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TTI2	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC53	RSM23	1	Unpublished Fields Lab Data
View Screen	CTF13	RSM23	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RSM23	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..112]	deduced	N/A	No confident structure predictions are available.
2	View Details	[113..398]	MSA	2.013928	View MSA. No confident structure predictions are available.
3	View Details	[399..488]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
structural constituent of ribosome	5.42139550243577	bayes_pls_golite062009
structural molecule activity	4.52418150951371	bayes_pls_golite062009
binding	2.00435458244286	bayes_pls_golite062009
catalytic activity	0.942640875796745	bayes_pls_golite062009
motor activity	0.934327429601554	bayes_pls_golite062009
nucleic acid binding	0.88509145478589	bayes_pls_golite062009
cytoskeletal protein binding	0.482433345604081	bayes_pls_golite062009
protein binding	0.409258528033042	bayes_pls_golite062009
microtubule motor activity	0.381564091226657	bayes_pls_golite062009
DNA binding	0.368768953337555	bayes_pls_golite062009
purine nucleotide binding	0.354154818458687	bayes_pls_golite062009
purine ribonucleotide binding	0.35085688811866	bayes_pls_golite062009
ribonucleotide binding	0.350844329183388	bayes_pls_golite062009
nucleotide binding	0.350227693353399	bayes_pls_golite062009
transcription regulator activity	0.181434122054025	bayes_pls_golite062009
translation regulator activity	0.165004576559811	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.144513585153713	bayes_pls_golite062009
RNA binding	0.10404338295854	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2