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Protein Overview: NUP157

General Information:
Name(s) found: NUP157 / YER105C [SGD]
Description(s) found:
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  • gi|731497|sp|P40064.1|NU157_YEAST RecName: Full=Nucleoporin NUP157; AltName: Full=Nuclear pore protein NUP157 [NCBI NR]
  • gi|6320952|ref|NP_011031.1| Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p; Nup157p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|603343|gb|AAB64660.1| Nup157p: nucleoporin [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50608 hypothetical protein YER105c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Nucleoporin NUP157 OS=Saccharomyces cerevisiae GN=NUP157 PE=1 SV=1 [Swiss-Prot]
  • (P40064) Nucleoporin NUP157 (Nuclear pore protein NUP157) [Swiss-Prot]
  • NUP157 Nuclear pore protein [mips]
  • Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly [SGD]
  • NUP157, Chr V from 367834-372009, reverse complement [yeast_orfs2]
  • Chr V from 367834-372009, reverse complement [yeastorf3.fasta]
  • Chr V from 372009-367834, reverse complement [yeastorf5.fasta]
  • NUP157 SGDID:S0000907, Chr V from 372009-367834, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p [Saccharomyces cerevisiae]gi|1077690|pir||S50608 hypothetical protein YER105c - yeast (Saccharomyces cerevisiae)gi|603343|gb|AAB64660.1| Nup1 [nrdb_11152004_Chlamydomonas]
  • NUP157 SGDID:S000000907, Chr V from 372009-367834, reverse complement, Verified ORF, "Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Nucleoporin NUP157 (Nuclear pore protein NUP157) [nr-271106-contam.fasta]
  • Nup157p: nucleoporin [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p; Nup157p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NUP157 SGDID:S000000907, Chr V from 372009-367834, reverse complement, Verified ORF, "Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • Nucleoporin NUP157 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUP157 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NUP157 SGDID:S000000907, Chr V from 372013-367838, Genome Release 64-1-1, reverse complement, Verified ORF, "Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly" [yeast-030211-contam.fasta]
  • NUP157 SGDID:S000000907, Chr V from 372013-367838, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YER105C SGDID:S000000907, Chr V from 372013-367838, Genome Release 64-1-1, reverse complement, Verified ORF, "Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1391 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [IMPLink to PubMed article][TASLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [TASLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSTPLKKRI DYDRETFTAS ASLGGNRLRN RPRDDQNNGK PNLSSRSFLS ERKTRKDVLN  60
   61 KYGEAGNTIE SELRDVTTHV KISGLTSSEP LQLASEFVQD LSFRDRNTPI LDNPDYYSKG 120
  121 LDYNFSDEVG GLGAFTPFQR QQVTNIPDEV LSQVSNTEIK SDMGIFLELN YCWITSDNKL 180
  181 ILWNINNSSE YHCIDEIEHT ILKVKLVKPS PNTFVSSVEN LLIVATLFDI YILTISFNDR 240
  241 THELNIFNTG LKVNVTGFNV SNIISYERTG QIFFTGATDG VNVWELQYNC SENLFNSKSN 300
  301 KICLTKSNLA NLLPTKLIPS IPGGKLIQKV LEGDAGTEEE TISQLEVDQS RGVLHTLSTK 360
  361 SIVRSYLITS NGLVGPVLID AAHIRRGMNA LGVKNSPLLS NRAFKIAKIV SISMCENNDL 420
  421 FLAVITTTGV RLYFKGSISR RSIGSLKLDS VKFPPTSISS SLEQNKSFII GHHPLNTHDT 480
  481 GPLSTQKASS TYINTTCAST IISPGIYFTC VRKRANSGEL SKGITNKALL ENKEEHKLYV 540
  541 SAPDYGILKN YGKYVENTAL LDTTDEIKEI VPLTRSFNYT STPQGYANVF ASQYSAEPLK 600
  601 VAVLTSNALE IYCYRTPDEV FESLIENPLP FIHSYGLSEA CSTALYLACK FNKSEHIKSS 660
  661 ALAFFSAGIP GVVEIKPKSS RESGSVPPIS QNLFDKSGEC DGIVLSPRFY GSALLITRLF 720
  721 SQIWEERVFV FKRASKTEKM DAFGISITRP QVEYYLSSIS VLADFFNIHR PSFVSFVPPK 780
  781 GSNAITASDA ESIAMNALIL LINSIKDALS LINVFYEDID AFKSLLNTLM GAGGVYDSKT 840
  841 REYFFDLKFH DLFTPNAKTK QLIKEILIEV VNANIASGTS ADYIVNVLKE RFGSFCHSAD 900
  901 ILCYRAGEHL EAAQKFEMID SKISRNHLDT AIDLYERCAE NIELCELRRV VDIMVKLNYQ 960
  961 PKTVGFLLRF ADKIDKGNQA QEYVSRGCNT ADPRKVFYDK RINVYTLIFE IVKSVDDYTS1020
 1021 IEQSPSIANI SIFSPASSLK KRVYSVIMNS NNRFFHYCFY DWLVANKRQD YLLRLDSQFV1080
 1081 LPYLKERAEK SLEISNLLWF YLFKEEHFLE AADVLYALAS SDFDLKLSER IECLARANGL1140
 1141 CDSSTSFDQK PALVQLSENI HELFDIASIQ DDLLNLVRNE TRIDEDYRKQ LTLKLNGRVL1200
 1201 PLSDLFNDCA DPLDYYEIKL RIFKVSQFKD EKVIQGEWNR LLDSMKNAPS PDVGSVGQES1260
 1261 FLSSISNTLI RIGKTTRDTD VVFPVHFLMN KILESFIDKS SAADGSVCSM FLLAGVSHLK1320
 1321 LYYILSRIIE NSEGNVELAK KEMVWLIKDW YQSDSDLRGS IAPEQIKKLE KYDPNTDPVQ1380
 1381 DYVKDRHHGL K

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Qiu et al. (2008) ASM4 DBP5 GLE2 KAP123 MEX67 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP49 NUP53 NUP57 NUP82 NUP84 NUP85 POM152 SEC13 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CLB5 NUP157 2 Unpublished Fields Lab Data
    View Screen PCF11 NUP157 2 Unpublished Fields Lab Data
    View Screen PRE4 NUP157 2 Unpublished Fields Lab Data
    View Screen YJL147C NUP157 2 Unpublished Fields Lab Data
    View Screen SOG2 NUP157 2 Unpublished Fields Lab Data
    View Screen PBP2 NUP157 1 Unpublished Fields Lab Data
    View Screen PCF11 NUP157 1 Unpublished Fields Lab Data
    View Screen PCF11 NUP157 1 Unpublished Fields Lab Data
    View Screen RRP17 NUP157 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUP157 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..65] deduced N/A No confident structure predictions are available.
    2 View Details [66..1391] Pfam 1000.0 Non-repetitive/WGA-negative nucleoporin No confident structure predictions are available.
    3 View Details [258..331] deduced N/A No confident structure predictions are available.
    4 View Details [332..437] MSA 1.048991 View MSA. No confident structure predictions are available.
    5 View Details [438..672] deduced N/A No confident structure predictions are available.
    6 View Details [673..856] deduced N/A No confident structure predictions are available.
    7 View Details [857..915] MSA 1.039993 View MSA. No confident structure predictions are available.
    8 View Details [916..1059] MSA 1.042967 View MSA. No confident structure predictions are available.
    9 View Details [1060..1247] MSA 1.042993 View MSA. No confident structure predictions are available.
    10 View Details [1248..1391] MSA 2.042984 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle