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Protein Overview: NTF2

General Information:
Name(s) found: NTF2 / YER009W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 125 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    Biological Process: nucleocytoplasmic transport [IMPLink to PubMed article]
    protein import into nucleus [IMPLink to PubMed article]
    Molecular Function: Ran GTPase binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLDFNTLAQ NFTQFYYNQF DTDRSQLGNL YRNESMLTFE TSQLQGAKDI VEKLVSLPFQ  60
   61 KVQHRITTLD AQPASPNGDV LVMITGDLLI DEEQNPQRFS QVFHLIPDGN SYYVFNDIFR 120
  121 LNYSA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 EGD1 ERG13 ERG6 FPR1 FRS2 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 LRO1 LSP1 MET6 NTF2 OLA1 OYE2 PFK1 PIL1 PRM2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 TEF4 THS1 TIF1, TIF2 TMA19 TSA2 UBA1 VMA4 VMA5 WTM1 YNK1
    View Details Qiu et al. (2008) KAP123 NTF2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] PSI-BLAST 630.045757 Nuclear transport factor-2 (NTF2)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  3.2858716221712 bayes_pls_golite062009
  • nucleocytoplasmic transporter activity
    		•  2.57260151088345 bayes_pls_golite062009
  • binding
    		•  2.32562999055027 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.22367856601071 bayes_pls_golite062009
  • transporter activity
    		•  1.80701285041353 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.33804818542017 bayes_pls_golite062009
  • structural constituent of nuclear pore
    		•  1.30758304562723 bayes_pls_golite062009
  • protein binding
    		•  1.24260899146543 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.22102896992563 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.18290069522408 bayes_pls_golite062009
  • RNA binding
    		•  1.05240446104847 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.890150150408175 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.79772386064313 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.79772386064313 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.688410645367506 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.446562877324676 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.439519001457896 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.430285640125175 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle