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Protein Overview: POL3

General Information:
Name(s) found: POL3 / YDL102W [SGD]
Description(s) found:
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  • gi|6320101|ref|NP_010181.1| Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair [NCBI NR]
  • pir||RNBYL3 DNA-directed DNA polymerase (EC 2.7.7.7) III large chain - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1706506|sp|P15436.3|DPOD_YEAST RecName: Full=DNA polymerase delta catalytic subunit; AltName: Full=DNA polymerase III [NCBI NR]
  • gi|1431142|emb|CAA98669.1| CDC2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1199547|emb|CAA64911.1| CDC2 [Saccharomyces cerevisiae] [NCBI NR]
  • DNA polymerase delta catalytic subunit OS=Saccharomyces cerevisiae GN=POL3 PE=1 SV=3 [Swiss-Prot]
  • CDC2 DNA-directed DNA polymerase delta, catalytic 125 KD subunit [mips]
  • Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) [SGD]
  • CDC2, Chr IV from 276871-280164 [yeast_orfs2]
  • Chr IV from 276871-280164 [yeastorf3.fasta]
  • (P15436) DNA polymerase delta catalytic subunit (EC 2.7.7.7) (DNA polymerase III) [4932.FASTACCERV.txt]
  • CDC2 SGDID:S0002260, Chr IV from 276872-280165, Verified ORF [yeastflysequest.fasta]
  • Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) [Saccharomyces cerevi [nrdb_11152004_Chlamydomonas]
  • CDC2 SGDID:S000002260, Chr IV from 276872-280165, Verified ORF, "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replicat [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • POL3 SGDID:S000002260, Chr IV from 276872-280165, Verified ORF, "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replicat [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • CDC2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • DNA polymerase delta catalytic subunit (DNA polymerase III) [nr-271106-contam.fasta]
  • Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER); Cdc2p [Saccharomyces [nr-271106-contam.fasta]
  • POL3 SGDID:S000002260, Chr IV from 276872-280165, Verified ORF, "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)" [yeast-bovrabprots.fasta]
  • CDC2 SGDID:S000002260, Chr IV from 276872-280165, Verified ORF, "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1097 amino acids

    Gene Ontology:
    Cellular Component: replication fork [IDALink to PubMed article]
    delta DNA polymerase complex [TASLink to PubMed article]
    Biological Process: mutagenesis [TASLink to PubMed article]
    lagging strand elongation [TASLink to PubMed article]
    base-excision repair [TASLink to PubMed article]
    leading strand elongation [TASLink to PubMed article]
    maintenance of fidelity involved in DNA-dependent DNA replication [IGILink to PubMed article]
    nucleotide-excision repair [TASLink to PubMed article]
    mismatch repair [NASLink to PubMed articleLink to PubMed article]
    postreplication repair [TASLink to PubMed article]
    Molecular Function: single-stranded DNA specific 3'-5' exodeoxyribonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKRSLPMV DVKIDDEDTP QLEKKIKRQS IDHGVGSEPV STIEIIPSDS FRKYNSQGFK  60
   61 AKDTDLMGTQ LESTFEQDVS QMEHDMADQE EHDLSSFERK KLPTDFDPSL YDISFQQIDA 120
  121 EQSVLNGIKD ENTSTVVRFF GVTSEGHSVL CNVTGFKNYL YVPAPNSSDA NDQEQINKFV 180
  181 HYLNETFDHA IDSIEVVSKQ SIWGYSGDTK LPFWKIYVTY PHMVNKLRTA FERGHLSFNS 240
  241 WFSNGTTTYD NIAYTLRLMV DCGIVGMSWI TLPKGKYSMI EPNNRVSSCQ LEVSINYRNL 300
  301 IAHPAEGDWS HTAPLRIMSF DIECAGRIGV FPEPEYDPVI QIANVVSIAG AKKPFIRNVF 360
  361 TLNTCSPITG SMIFSHATEE EMLSNWRNFI IKVDPDVIIG YNTTNFDIPY LLNRAKALKV 420
  421 NDFPYFGRLK TVKQEIKESV FSSKAYGTRE TKNVNIDGRL QLDLLQFIQR EYKLRSYTLN 480
  481 AVSAHFLGEQ KEDVHYSIIS DLQNGDSETR RRLAVYCLKD AYLPLRLMEK LMALVNYTEM 540
  541 ARVTGVPFSY LLARGQQIKV VSQLFRKCLE IDTVIPNMQS QASDDQYEGA TVIEPIRGYY 600
  601 DVPIATLDFN SLYPSIMMAH NLCYTTLCNK ATVERLNLKI DEDYVITPNG DYFVTTKRRR 660
  661 GILPIILDEL ISARKRAKKD LRDEKDPFKR DVLNGRQLAL KISANSVYGF TGATVGKLPC 720
  721 LAISSSVTAY GRTMILKTKT AVQEKYCIKN GYKHDAVVVY GDTDSVMVKF GTTDLKEAMD 780
  781 LGTEAAKYVS TLFKHPINLE FEKAYFPYLL INKKRYAGLF WTNPDKFDKL DQKGLASVRR 840
  841 DSCSLVSIVM NKVLKKILIE RNVDGALAFV RETINDILHN RVDISKLIIS KTLAPNYTNP 900
  901 QPHAVLAERM KRREGVGPNV GDRVDYVIIG GNDKLYNRAE DPLFVLENNI QVDSRYYLTN 960
  961 QLQNPIISIV APIIGDKQAN GMFVVKSIKI NTGSQKGGLM SFIKKVEACK SCKGPLRKGE1020
 1021 GPLCSNCLAR SGELYIKALY DVRDLEEKYS RLWTQCQRCA GNLHSEVLCS NKNCDIFYMR1080
 1081 VKVKKELQEK VEQLSKW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) POL3 POL31
    View Details (MIPS) Mewes HW, et al. (2004) CDC45 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL31 POL32
    View Details Krogan NJ, et al. (2006) POL3 POL30 POL31 POL32
    View Details Gavin AC, et al. (2006) POL3 POL31
    View Details Qiu et al. (2008) CDC45 CDC9 DPB11 DPB2 DPB3 DPB4 HCS1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC5 POL1 POL12 POL2 POL3 POL30 POL31 POL32 PRI1 PRI2 RAD30 REV3 REV7 RFC1 RFC4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NAF1 POL3 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data POL3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] deduced N/A No confident structure predictions are available.
    2 View Details [76..157]
    [251..578]    		 PSI-BLAST 1532.218487 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    3 View Details [158..250]
    [579..589]
    [611..731]    		 PSI-BLAST 1532.218487 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    4 View Details [590..610]
    [732..833]    		 PSI-BLAST 1532.218487 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    5 View Details [834..1007] PSI-BLAST 1532.218487 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    6 View Details [1008..1097] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle