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Protein Overview: GRX1

General Information:
Name(s) found: GRX1 / YCL035C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 110 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to oxidative stress [IMPLink to PubMed article]
    Molecular Function: glutathione peroxidase activity [IDALink to PubMed article]
    thiol-disulfide exchange intermediate activity [ISSLink to PubMed article]
    glutathione transferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSQETIKHV KDLIAENEIF VASKTYCPYC HAALNTLFEK LKVPRSKVLV LQLNDMKEGA  60
   61 DIQAALYEIN GQRTVPNIYI NGKHIGGNDD LQELRETGEL EELLEPILAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 EGD1 ERG13 ERG6 FPR1 FRS2 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 LRO1 LSP1 MET6 NTF2 OLA1 OYE2 PFK1 PIL1 PRM2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 TEF4 THS1 TIF1, TIF2 TMA19 TSA2 UBA1 VMA4 VMA5 WTM1 YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GRX1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 98.522879 Glutaredoxin (Grx, thioltransferase)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle