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View Structure Prediction Details

Protein: RHO5
Organism: Saccharomyces cerevisiae
Length: 331 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RHO5.

Description E-value Query
Range		 Subject
Range
RHO5_YEAST - GTP-binding protein RHO5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RHO5 PE=1 SV=2
RHO5 - Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein...
 0.0 [1..331] [1..331]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..329] [1..329]
RAC1_CANLF - Ras-related C3 botulinum toxin substrate 1 OS=Canis lupus familiaris GN=RAC1 PE=2 SV=1
RAC1 - ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
gi|90085276 - gi|90085276|dbj|BAE91379.1| unnamed protein product [Macaca fascicularis]
gi|117616674, gi... - gi|208967264|dbj|BAG73646.1| ras-related C3 botulinum toxin substrate 1 [synthetic construct], gi|19...
gi|149636782 - gi|149636782|ref|XP_001506443.1| PREDICTED: similar to Chain B, Activated Rac1 Bound To Its Effector...
RAC1_MOUSE - Ras-related C3 botulinum toxin substrate 1 OS=Mus musculus GN=Rac1 PE=1 SV=1
RAC1_BOVIN - Ras-related C3 botulinum toxin substrate 1 OS=Bos taurus GN=RAC1 PE=1 SV=1
gi|3184510, gi|4... - gi|45384330|ref|NP_990348.1| ras-related C3 botulinum toxin substrate 1 (rho family, small GTP bindi...
RAC1_RAT - Ras-related C3 botulinum toxin substrate 1 OS=Rattus norvegicus GN=Rac1 PE=1 SV=1
gi|89272838, gi|... - gi|89272838|emb|CAJ83626.1| ras-related C3 botulinum toxin substrate 1 (rho family, small GTP bindin...
ENSPTRT00000034946 - null
gi|238566849, gi... - gi|240849265|ref|NP_001155328.1| ras-related C3 botulinum toxin substrate 1 (rho family, small GTP b...
 9.0E-88 [1..229] [1..188]
gi|5738220, gi|8... - gi|80476985|gb|AAI08885.1| RAC1 protein [Xenopus laevis], gi|5738220|gb|AAD50299.1|AF174644_1 rac GT...
 2.0E-87 [1..229] [1..188]
gi|12842616 - gi|12842616|dbj|BAB25667.1| unnamed protein product [Mus musculus]
 4.0E-87 [1..229] [1..188]

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Predicted Domain #1
Region A:
Residues: [1-279] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSIKCVIIG DGAVGKTSLL ISYTTNSFPT DYVPTVFDNY STTIAIPNGT ASSPLELDNG  60
   61 NDKRGSLSSA SSSPSTDRKL YKINLWDTAG QEDYDRLRPL CYPQTDIFLI CFSVSEHASF 120
  121 ANVTEKWLPE LKQTSNIEGT SLYTKLGKYP ILLVGTKSDL RDDPATQKKL QEANSDYVSQ 180
  181 EEIDELVQRC GFMGYTECSA ATQAGVREVF EQAVRYAIYE PESPNQKSAN HTLTDELTTA 240
  241 TTNTNGDKNI REQKQQPHHN NSTDSTLPKG SLQQEKEAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 591.533179
Match: 1i4dD_
Description: Rac
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 4.52394549632777 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 4.26230696590213 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
microtubule motor activity 3.91769993918004 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 3.35170865169069 bayes_pls_golite062009
actin binding 3.33639699088484 bayes_pls_golite062009
microfilament motor activity 3.17800963620802 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
hydrolase activity 2.73675310079844 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
G-protein coupled receptor activity 2.3505608190884 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
actin filament binding 2.24723363507804 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
amine-transporting ATPase activity 2.06822309603506 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 1.95782378818812 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.77111739879769 bayes_pls_golite062009
structural constituent of muscle 1.75982319871463 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 1.75695995185278 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
actin-dependent ATPase activity 1.58897222423517 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
transmembrane receptor activity 1.26314334516725 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
receptor activity 1.20313362488821 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
kinase activity 1.11120928120082 bayes_pls_golite062009
ADP binding 1.10601354993582 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
GBD domain binding 0.914270985726459 bayes_pls_golite062009
peptide-transporting ATPase activity 0.911425383309011 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.908046791062776 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
peptide transporter activity 0.73541731084591 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
potassium channel activity 0.694411056320469 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 0.621822998821133 bayes_pls_golite062009
cell surface binding 0.618263399939881 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
amino acid transmembrane transporter activity 0.585668369219566 bayes_pls_golite062009
nucleotide kinase activity 0.56979593127581 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.567883621045161 bayes_pls_golite062009
beta-catenin binding 0.567325521781475 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
DNA strand annealing activity 0.495691434532349 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.421921195209539 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
peptide binding 0.304703625340488 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
myosin binding 0.274885859454447 bayes_pls_golite062009
voltage-gated calcium channel activity 0.25979628626254 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [280-331] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIKPTKKGQK DKIHEQSKSK GSKIASNNHH NKQAKPKTRN DKKKKKSKCV IL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle