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View Structure Prediction Details

Protein: ATM1
Organism: Saccharomyces cerevisiae
Length: 690 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATM1.

Description E-value Query
Range		 Subject
Range
gi|57526446, gi|... - gi|57526446|ref|NP_001009790.1| ATP-binding cassette, subfamily B, member 1 [Ovis aries], gi|2149087...
 0.0 [74..690] [22..650]
ABCB1 - ATP-binding cassette, sub-family B (MDR/TAP), member 1
gi|117645528 - gi|117645528|emb|CAL38230.1| hypothetical protein [synthetic construct]
 0.0 [73..688] [17..643]
MDR1_CRIGR - Multidrug resistance protein 1 OS=Cricetulus griseus GN=ABCB1 PE=1 SV=2
 0.0 [73..688] [16..640]
gi|149029024, gi... - gi|7739773|gb|AAF69007.1|AF257746_1 multidrug resistance protein 1a [Rattus norvegicus], gi|62646634...
 0.0 [77..685] [20..632]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [73..688] [16..640]
gi|8926217 - gi|8926217|gb|AAF81747.1| his-tagged-multidrug resistance glycoprotein MDR1 [synthetic construct]
 0.0 [75..683] [25..646]
gi|50978984, gi|... - gi|50978984|ref|NP_001003215.1| ATP-binding cassette, subfamily B, member 1 [Canis lupus familiaris]...
 0.0 [73..683] [16..639]
MDR3_MOUSE - Multidrug resistance protein 3 OS=Mus musculus GN=Abcb1a PE=2 SV=2
 0.0 [77..685] [20..636]

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Predicted Domain #1
Region A:
Residues: [1-67] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLPRCPVI GRIVRSKFRS GLIRNHSPVI FTVSKLSTQR PLLFNSAVNL WNQAQKDITH  60
   61 KKSVEQF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.643 0.900 ATPase activity, coupled to transmembrane movement of substances d.58.17 Metal-binding domain
View Download 0.721 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.5 "Winged helix" DNA-binding domain
View Download 0.643 0.900 ATPase activity, coupled to transmembrane movement of substances d.58.17 Metal-binding domain
View Download 0.721 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.5 "Winged helix" DNA-binding domain
View Download 0.707 0.900 ATPase activity, coupled to transmembrane movement of substances d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.707 0.900 ATPase activity, coupled to transmembrane movement of substances d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.666 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.5 "Winged helix" DNA-binding domain
View Download 0.653 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.5 "Winged helix" DNA-binding domain
View Download 0.605 0.900 ATPase activity, coupled to transmembrane movement of substances d.94.1 HPr-like
View Download 0.570 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.5 "Winged helix" DNA-binding domain
View Download 0.530 0.900 ATPase activity, coupled to transmembrane movement of substances a.64.1 Saposin
View Download 0.520 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.1 Homeodomain-like
View Download 0.516 0.900 ATPase activity, coupled to transmembrane movement of substances d.58.11 EF-G/eEF-2 domains III and V
View Download 0.501 0.900 ATPase activity, coupled to transmembrane movement of substances a.144.1 PABC (PABP) domain
View Download 0.492 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.1 Homeodomain-like
View Download 0.482 0.900 ATPase activity, coupled to transmembrane movement of substances a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.459 0.900 ATPase activity, coupled to transmembrane movement of substances a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.457 0.900 ATPase activity, coupled to transmembrane movement of substances d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.454 0.900 ATPase activity, coupled to transmembrane movement of substances a.64.1 Saposin
View Download 0.443 0.900 ATPase activity, coupled to transmembrane movement of substances a.60.9 lambda integrase-like, N-terminal domain
View Download 0.440 0.900 ATPase activity, coupled to transmembrane movement of substances a.17.1 p8-MTCP1
View Download 0.425 0.900 ATPase activity, coupled to transmembrane movement of substances a.21.1 HMG-box
View Download 0.390 0.900 ATPase activity, coupled to transmembrane movement of substances a.64.2 Bacteriocin AS-48
View Download 0.382 0.900 ATPase activity, coupled to transmembrane movement of substances d.68.4 YhbY-like
View Download 0.364 0.900 ATPase activity, coupled to transmembrane movement of substances a.118.11 Cytochrome c oxidase subunit E
View Download 0.357 0.900 ATPase activity, coupled to transmembrane movement of substances d.68.3 SirA-like
View Download 0.349 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.8 Ribosomal protein S18
View Download 0.343 0.900 ATPase activity, coupled to transmembrane movement of substances d.58.8 Viral DNA-binding domain
View Download 0.320 0.900 ATPase activity, coupled to transmembrane movement of substances a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.309 0.900 ATPase activity, coupled to transmembrane movement of substances a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.303 0.900 ATPase activity, coupled to transmembrane movement of substances d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.251 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.1 Homeodomain-like
View Download 0.242 0.900 ATPase activity, coupled to transmembrane movement of substances d.56.1 GroEL-intermediate domain like
View Download 0.231 0.900 ATPase activity, coupled to transmembrane movement of substances a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.231 0.900 ATPase activity, coupled to transmembrane movement of substances a.60.1 SAM/Pointed domain
View Download 0.219 0.900 ATPase activity, coupled to transmembrane movement of substances d.68.6 DNA-binding protein Sso10b (AlbA)
View Download 0.217 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.208 0.900 ATPase activity, coupled to transmembrane movement of substances d.58.3 Protease propeptides/inhibitors
View Download 0.207 0.900 ATPase activity, coupled to transmembrane movement of substances a.4.1 Homeodomain-like
View Download 0.203 0.900 ATPase activity, coupled to transmembrane movement of substances d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain

Predicted Domain #2
Region A:
Residues: [68-197] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSAPKVKTQV KKTSKAPTLS ELKILKDLFR YIWPKGNNKV RIRVLIALGL LISAKILNVQ  60
   61 VPFFFKQTID SMNIAWDDPT VALPAAIGLT ILCYGVARFG SVLFGELRNA VFAKVAQNAI 120
  121 RTVSLQTFQH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [216-414] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAMDRGTKGI SQVLTAMVFH IIPISFEISV VCGILTYQFG ASFAAITFST MLLYSIFTIK  60
   61 TTAWRTHFRR DANKADNKAA SVALDSLINF EAVKYFNNEK YLADKYNGSL MNYRDSQIKV 120
  121 SQSLAFLNSG QNLIFTTALT AMMYMGCTGV IGGNLTVGDL VLINQLVFQL SVPLNFLGSV 180
  181 YRDLKQSLID METLFKLRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 745.9897
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lipid transporter activity 7.47642599298853 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.57844095962502 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.57813579764186 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.57813579764186 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.5689620139321 bayes_pls_golite062009
primary active transmembrane transporter activity 5.55992639965745 bayes_pls_golite062009
active transmembrane transporter activity 5.50005167063544 bayes_pls_golite062009
ATPase activity, coupled 4.98276715440477 bayes_pls_golite062009
heme transporter activity 4.82479229680991 bayes_pls_golite062009
peptide transporter activity 4.7442815698413 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.71935767060308 bayes_pls_golite062009
ATPase activity 4.69795387297193 bayes_pls_golite062009
peptide-transporting ATPase activity 4.63590351019108 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.45923622153365 bayes_pls_golite062009
pyrophosphatase activity 4.39781350157199 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.38133275795019 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.38085303582726 bayes_pls_golite062009
cofactor transporter activity 4.34709589308604 bayes_pls_golite062009
oligopeptide-transporting ATPase activity 4.09365342567844 bayes_pls_golite062009
transporter activity 3.71239480053329 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 3.20894563245332 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 3.16975154423199 bayes_pls_golite062009
hydrolase activity 3.14498892233323 bayes_pls_golite062009
transmembrane transporter activity 3.13960906549884 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
substrate-specific transporter activity 3.1318898376276 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
ATP binding 3.01346604299372 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.00745742755195 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
adenyl ribonucleotide binding 2.96271391116269 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
adenyl nucleotide binding 2.91131545957759 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
purine ribonucleotide binding 2.70262534541085 bayes_pls_golite062009
ribonucleotide binding 2.70178191749524 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
purine nucleotide binding 2.6583477492092 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
nucleotide binding 2.62374702628143 bayes_pls_golite062009
sterol transporter activity 2.48473697371886 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
vitamin transporter activity 2.1653565229854 bayes_pls_golite062009
phosphate transmembrane transporter activity 2.15147988861177 bayes_pls_golite062009
oligopeptide transporter activity 2.05580564974083 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
binding 1.64266915208623 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 1.28313088935613 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 1.28313088935613 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
potassium channel activity 1.20877745413881 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 1.1220946941463 bayes_pls_golite062009
dipeptide transporter activity 1.01130176523309 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
signal transducer activity 0.952448314982579 bayes_pls_golite062009
molecular transducer activity 0.952448314982579 bayes_pls_golite062009
RNA helicase activity 0.94708387424268 bayes_pls_golite062009
thiamin transmembrane transporter activity 0.933872128802939 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.93133090558732 bayes_pls_golite062009
RNA-dependent ATPase activity 0.91827876091109 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.798934081014025 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
helicase activity 0.73689027003638 bayes_pls_golite062009
ATP-dependent helicase activity 0.72833102894594 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.72833102894594 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
cholesterol transporter activity 0.644421039250979 bayes_pls_golite062009
DNA-dependent ATPase activity 0.62832939629645 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
catalytic activity 0.368034275052766 bayes_pls_golite062009
receptor activity 0.277332279568238 bayes_pls_golite062009
transmembrane receptor activity 0.243026482777117 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
nucleic acid binding 0.144904409289829 bayes_pls_golite062009
sulfate transmembrane transporter activity 0.104477131120205 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structure-specific DNA binding 0.050232896280066 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [198-215] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMKLDLGWHL SRQTGGLT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [415-690] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEVKIKNAER PLMLPENVPY DITFENVTFG YHPDRKILKN ASFTIPAGWK TAIVGSSGSG  60
   61 KSTILKLVFR FYDPESGRIL INGRDIKEYD IDALRKVIGV VPQDTPLFND TIWENVKFGR 120
  121 IDATDEEVIT VVEKAQLAPL IKKLPQGFDT IVGERGLMIS GGEKQRLAIA RVLLKNARIM 180
  181 FFDEATSALD THTEQALLRT IRDNFTSGSR TSVYIAHRLR TIADADKIIV LDNGRVREEG 240
  241 KHLELLAMPG SLYRELWTIQ EDLDHLENEL KDQQEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 745.9897
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle