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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Apm1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APL2
  • AP-1 adaptor complex
  • vesicle-mediated transport
  • Golgi to vacuole transport
  • clathrin binding
  • APL4
  • AP-1 adaptor complex
  • vesicle-mediated transport
  • Golgi to vacuole transport
  • clathrin binding
  • APM1
  • AP-1 adaptor complex
  • vesicle-mediated transport
  • Golgi to vacuole transport
  • clathrin binding
  • BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • KRI1
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • KRR1
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • NMA1
  • nucleus
  • cytoplasm
  • NAD metabolic process
  • nicotinamide-nucleotide adenylyltransferase activity
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • PAB1
  • nucleus
  • cytoplasm
  • ribosome
  • regulation of translational initiation
  • poly(A) RNA binding
  • PWP1
  • nucleus
  • cytoplasm
  • nucleolus
  • rRNA processing
  • molecular_function
  • RCL1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • RNA-3'-phosphate cyclase activity
  • molecular_function
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • TUF1
  • mitochondrial matrix
  • mitochondrion
  • translational elongation
  • translation elongation factor activity
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.9043E-10 15 211 9 6292
    nuclear lumen 1.6291E-7 15 453 9 6292
    clathrin coat of trans-Golgi network vesicle 2.1836E-7 15 6 3 6292
    AP-1 adaptor complex 2.1836E-7 15 6 3 6292
    organelle lumen 2.7815E-7 15 660 10 6292
    intracellular organelle lumen 2.7815E-7 15 660 10 6292
    trans-Golgi network transport vesicle membrane 3.8158E-7 15 7 3 6292
    membrane-enclosed lumen 4.8715E-7 15 700 10 6292
    clathrin adaptor complex 1.3027E-6 15 10 3 6292
    trans-Golgi network transport vesicle 1.7886E-6 15 11 3 6292
    clathrin vesicle coat 3.9288E-6 15 14 3 6292
    clathrin coat 3.9288E-6 15 14 3 6292
    AP-type membrane coat adaptor complex 3.9288E-6 15 14 3 6292
    clathrin coated vesicle membrane 4.904E-6 15 15 3 6292
    transport vesicle membrane 4.904E-6 15 15 3 6292
    Golgi-associated vesicle membrane 6.027E-6 15 16 3 6292
    non-membrane-bounded organelle 9.3448E-6 15 959 10 6292
    intracellular non-membrane-bounded organelle 9.3448E-6 15 959 10 6292
    endomembrane system 1.5875E-5 15 398 7 6292
    nuclear outer membrane 3.9595E-5 15 86 4 6292
    clathrin-coated vesicle 4.7349E-5 15 31 3 6292
    vesicle coat 6.2763E-5 15 34 3 6292
    nuclear membrane 6.3611E-5 15 97 4 6292
    coated vesicle membrane 6.8549E-5 15 35 3 6292
    cytoplasmic vesicle membrane 6.8549E-5 15 35 3 6292
    vesicle membrane 6.8549E-5 15 35 3 6292
    intracellular organelle part 8.5313E-5 15 2282 13 6292
    organelle part 8.5313E-5 15 2282 13 6292
    membrane coat 8.7975E-5 15 38 3 6292
    coated membrane 8.7975E-5 15 38 3 6292
    cytoplasmic vesicle part 9.517E-5 15 39 3 6292
    Golgi-associated vesicle 1.0274E-4 15 40 3 6292
    transport vesicle 1.465E-4 15 45 3 6292
    Golgi membrane 1.8913E-4 15 49 3 6292
    nuclear part 2.753E-4 15 1103 9 6292
    membrane part 4.1715E-4 15 662 7 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    organelle membrane 5.4933E-4 15 692 7 6292
    outer membrane 6.6197E-4 15 178 4 6292
    organelle outer membrane 6.6197E-4 15 178 4 6292
    coated vesicle 8.9828E-4 15 83 3 6292
    nuclear envelope 1.0074E-3 15 199 4 6292
    nucleus 1.3856E-3 15 2041 11 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292
    nuclear membrane-endoplasmic reticulum network 1.7834E-3 15 232 4 6292
    membrane-bounded vesicle 1.8748E-3 15 107 3 6292
    cytoplasmic vesicle 1.8748E-3 15 107 3 6292
    cytoplasmic membrane-bounded vesicle 1.8748E-3 15 107 3 6292
    vesicle 2.0297E-3 15 110 3 6292
    Golgi apparatus part 2.5421E-3 15 119 3 6292
    Golgi apparatus 7.0542E-3 15 171 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.5492E-8 15 346 9 6292
    ribonucleoprotein complex biogenesis 3.0671E-8 15 374 9 6292
    cellular component biogenesis 6.2228E-6 15 694 9 6292
    ribosomal large subunit biogenesis 1.3003E-5 15 65 4 6292
    Golgi to vacuole transport 2.1535E-5 15 24 3 6292
    post-Golgi vesicle-mediated transport 5.0063E-4 15 68 3 6292
    establishment of ribosome localization 1.6681E-3 15 26 2 6292
    ribosome localization 1.6681E-3 15 26 2 6292
    ribosomal subunit export from nucleus 1.6681E-3 15 26 2 6292
    vacuolar transport 2.3055E-3 15 115 3 6292
    rRNA processing 3.1286E-3 15 128 3 6292
    rRNA metabolic process 3.7927E-3 15 137 3 6292
    cellular process 5.0732E-3 15 4426 15 6292
    Golgi vesicle transport 6.7162E-3 15 168 3 6292
    establishment of organelle localization 7.324E-3 15 55 2 6292
    intracellular transport 7.3438E-3 15 553 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    clathrin binding 1.7886E-6 15 11 3 6292
    binding 1.4204E-4 15 1294 10 6292
    ribosomal large subunit binding 2.384E-3 15 1 1 6292
    RNA-3'-phosphate cyclase activity 2.384E-3 15 1 1 6292
    nicotinamide-nucleotide adenylyltransferase activity 2.384E-3 15 1 1 6292
    cyclase activity 4.7627E-3 15 2 1 6292
    5S rRNA binding 4.7627E-3 15 2 1 6292
    ligase activity, forming phosphoric ester bonds 9.5041E-3 15 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle