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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Glc7. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADH4
  • mitochondrion
  • fermentation
  • NADH oxidation
  • alcohol dehydrogenase activity, zinc-dependent
  • FPR3
  • nucleolus
  • meiotic recombination checkpoint
  • peptidyl-prolyl cis-trans isomerase activity
  • FPR4
  • nucleus
  • chromatin
  • chromatin silencing at rDNA
  • negative regulation of histone H3-K36 methylation
  • ribosome biogenesis
  • histone peptidyl-prolyl isomerization
  • positive regulation of transcription from RNA polymerase II promoter
  • nucleosome assembly
  • peptidyl-prolyl cis-trans isomerase activity
  • histone binding
  • GLC7
  • protein phosphatase type 1 complex
  • mRNA cleavage and polyadenylation specificity factor complex
  • cellular bud neck
  • spindle pole body
  • nuclear outer membrane
  • nucleolus
  • mating projection base
  • mitotic cell cycle spindle assembly checkpoint
  • cell morphogenesis during vegetative growth
  • protein amino acid dephosphorylation
  • chromosome segregation
  • cell budding
  • cellular ion homeostasis
  • meiosis
  • regulation of carbohydrate metabolic process
  • ascospore formation
  • response to heat
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • glycogen metabolic process
  • termination of RNA polymerase II transcription, poly(A)-independent
  • histone dephosphorylation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • RNA binding
  • metal ion binding
  • hydrolase activity
  • GLC8
  • nucleus
  • cytoplasm
  • glycogen biosynthetic process
  • chromosome segregation
  • enzyme activator activity
  • GSY1
  • cytoplasm
  • mitochondrion
  • glycogen biosynthetic process
  • glycogen (starch) synthase activity
  • GSY2
  • cytoplasm
  • glycogen biosynthetic process
  • glycogen (starch) synthase activity
  • MDH1
  • mitochondrial matrix
  • mitochondrion
  • malate metabolic process
  • tricarboxylic acid cycle
  • L-malate dehydrogenase activity
  • PDC5
  • nucleus
  • cytoplasm
  • cytosol
  • pyruvate metabolic process
  • glucose catabolic process to ethanol
  • pyruvate decarboxylase activity
  • SDS22
  • nucleus
  • cytoplasm
  • protein targeting
  • chromosome segregation
  • protein phosphatase type 1 regulator activity
  • enzyme regulator activity
  • YPI1
  • nucleus
  • glycogen metabolic process
  • protein amino acid dephosphorylation
  • phosphoprotein phosphatase inhibitor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    energy derivation by oxidation of organic compounds 1.2745E-11 11 149 8 6292
    generation of precursor metabolites and energy 1.1254E-10 11 195 8 6292
    glycogen metabolic process 1.1098E-9 11 32 5 6292
    energy reserve metabolic process 1.1098E-9 11 32 5 6292
    cellular glucan metabolic process 5.2584E-9 11 43 5 6292
    glucan metabolic process 5.2584E-9 11 43 5 6292
    glucose metabolic process 1.0139E-8 11 109 6 6292
    cellular polysaccharide metabolic process 1.8822E-8 11 55 5 6292
    hexose metabolic process 2.2128E-8 11 124 6 6292
    polysaccharide metabolic process 2.9432E-8 11 60 5 6292
    monosaccharide metabolic process 3.6941E-8 11 135 6 6292
    small molecule metabolic process 2.2994E-7 11 760 9 6292
    alcohol metabolic process 6.8136E-7 11 220 6 6292
    glycogen biosynthetic process 1.7886E-6 11 15 3 6292
    cellular carbohydrate metabolic process 1.9083E-6 11 262 6 6292
    carbohydrate metabolic process 2.8772E-6 11 281 6 6292
    glucan biosynthetic process 6.9087E-6 11 23 3 6292
    cellular polysaccharide biosynthetic process 1.9183E-5 11 32 3 6292
    polysaccharide biosynthetic process 2.5241E-5 11 35 3 6292
    cellular carbohydrate biosynthetic process 2.8155E-4 11 78 3 6292
    carbohydrate biosynthetic process 4.4404E-4 11 91 3 6292
    fermentation 5.1901E-4 11 20 2 6292
    protein amino acid dephosphorylation 1.0247E-3 11 28 2 6292
    negative regulation of organelle organization 1.0996E-3 11 29 2 6292
    negative regulation of cellular component organization 1.0996E-3 11 29 2 6292
    chromosome segregation 1.2042E-3 11 128 3 6292
    negative regulation of cell cycle process 1.3395E-3 11 32 2 6292
    negative regulation of histone H3-K36 methylation 1.7483E-3 11 1 1 6292
    regulation of histone H3-K36 methylation 1.7483E-3 11 1 1 6292
    protein peptidyl-prolyl isomerization 1.7483E-3 11 1 1 6292
    histone peptidyl-prolyl isomerization 1.7483E-3 11 1 1 6292
    histone H3-K36 methylation 1.7483E-3 11 1 1 6292
    regulation of histone methylation 1.7483E-3 11 1 1 6292
    negative regulation of histone methylation 1.7483E-3 11 1 1 6292
    negative regulation of histone modification 1.7483E-3 11 1 1 6292
    regulation of histone modification 1.7483E-3 11 1 1 6292
    dephosphorylation 2.0904E-3 11 40 2 6292
    histone lysine methylation 3.4937E-3 11 2 1 6292
    meiotic prophase I 3.4937E-3 11 2 1 6292
    histone dephosphorylation 3.4937E-3 11 2 1 6292
    meiotic cell cycle checkpoint 3.4937E-3 11 2 1 6292
    prophase 3.4937E-3 11 2 1 6292
    regulation of chromosome organization 3.4937E-3 11 2 1 6292
    meiotic recombination checkpoint 3.4937E-3 11 2 1 6292
    regulation of organelle organization 3.5132E-3 11 52 2 6292
    cell cycle checkpoint 4.3546E-3 11 58 2 6292
    malate metabolic process 6.9763E-3 11 4 1 6292
    negative regulation of protein modification process 6.9763E-3 11 4 1 6292
    regulation of cellular component organization 7.1927E-3 11 75 2 6292
    negative regulation of cellular process 8.0677E-3 11 250 3 6292
    negative regulation of biological process 8.3385E-3 11 253 3 6292
    regulation of cell cycle process 8.35E-3 11 81 2 6292
    covalent chromatin modification 9.7997E-3 11 88 2 6292
    histone modification 9.7997E-3 11 88 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    glycogen (starch) synthase activity 2.779E-6 11 2 2 6292
    cis-trans isomerase activity 2.5001E-4 11 14 2 6292
    UDP-glucosyltransferase activity 2.5001E-4 11 14 2 6292
    peptidyl-prolyl cis-trans isomerase activity 2.5001E-4 11 14 2 6292
    glucosyltransferase activity 3.2905E-4 11 16 2 6292
    protein phosphatase regulator activity 6.8913E-4 11 23 2 6292
    phosphatase regulator activity 6.8913E-4 11 23 2 6292
    UDP-glycosyltransferase activity 9.5242E-4 11 27 2 6292
    alcohol dehydrogenase activity, zinc-dependent 3.4937E-3 11 2 1 6292
    enzyme regulator activity 4.7623E-3 11 207 3 6292
    isomerase activity 4.8071E-3 11 61 2 6292
    phosphoprotein phosphatase inhibitor activity 5.2364E-3 11 3 1 6292
    phosphatase inhibitor activity 5.2364E-3 11 3 1 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6.8247E-3 11 73 2 6292
    pyruvate decarboxylase activity 6.9763E-3 11 4 1 6292
    L-malate dehydrogenase activity 6.9763E-3 11 4 1 6292
    transferase activity, transferring hexosyl groups 8.1516E-3 11 80 2 6292
    oxidoreductase activity, acting on CH-OH group of donors 8.35E-3 11 81 2 6292
    malate dehydrogenase activity 8.7135E-3 11 5 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle