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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ccr4. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CCR4
  • cytoplasm
  • Cdc73/Paf1 complex
  • CCR4-NOT core complex
  • response to drug
  • traversing start control point of mitotic cell cycle
  • nuclear-transcribed mRNA poly(A) tail shortening
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • 3'-5'-exoribonuclease activity
  • CDC36
  • nucleus
  • cytoplasm
  • CCR4-NOT core complex
  • negative regulation of transcription from RNA polymerase II promoter
  • response to pheromone involved in conjugation with cellular fusion
  • nuclear-transcribed mRNA poly(A) tail shortening
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • 3'-5'-exoribonuclease activity
  • CDC39
  • nucleus
  • cytoplasm
  • CCR4-NOT core complex
  • negative regulation of transcription from RNA polymerase II promoter
  • response to pheromone involved in conjugation with cellular fusion
  • pseudohyphal growth
  • nuclear-transcribed mRNA poly(A) tail shortening
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • 3'-5'-exoribonuclease activity
  • CYS4
  • cytoplasm
  • mitochondrion
  • response to drug
  • cysteine biosynthetic process
  • cystathionine beta-synthase activity
  • PIL1
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • eisosome
  • response to heat
  • protein localization
  • endocytosis
  • protein kinase inhibitor activity
  • POP2
  • cytoplasm
  • CCR4-NOT core complex
  • nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • 3'-5'-exoribonuclease activity
  • RNQ1
  • cytosol
  • biological_process
  • molecular_function
  • RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • UBR1
  • proteasome complex
  • protein polyubiquitination
  • protein monoubiquitination
  • ubiquitin-protein ligase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    CCR4-NOT core complex 2.2463E-10 10 8 4 6292
    CCR4-NOT complex 3.1975E-9 10 14 4 6292
    transcription factor complex 2.971E-6 10 71 4 6292
    nucleoplasm part 3.9134E-4 10 245 4 6292
    protein complex 4.4574E-4 10 1137 7 6292
    nucleoplasm 5.2074E-4 10 264 4 6292
    eisosome 3.1764E-3 10 2 1 6292
    nuclear lumen 3.9246E-3 10 453 4 6292
    macromolecular complex 4.416E-3 10 1635 7 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear-transcribed mRNA poly(A) tail shortening 2.2463E-10 10 8 4 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 5.5505E-8 10 27 4 6292
    mRNA 3'-end processing 9.9209E-8 10 31 4 6292
    nuclear-transcribed mRNA catabolic process 2.3149E-7 10 38 4 6292
    RNA elongation from RNA polymerase II promoter 2.5775E-7 10 39 4 6292
    RNA 3'-end processing 3.4995E-7 10 42 4 6292
    RNA elongation 4.6477E-7 10 45 4 6292
    mRNA catabolic process 2.6475E-6 10 69 4 6292
    RNA catabolic process 4.8026E-6 10 80 4 6292
    regulation of transcription from RNA polymerase II promoter 1.2989E-5 10 228 5 6292
    mRNA processing 6.7975E-5 10 156 4 6292
    transcription from RNA polymerase II promoter 8.3842E-5 10 335 5 6292
    regulation of transcription, DNA-dependent 1.1524E-4 10 358 5 6292
    regulation of RNA metabolic process 1.2314E-4 10 363 5 6292
    regulation of transcription 1.6101E-4 10 384 5 6292
    mRNA metabolic process 2.2838E-4 10 213 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.3277E-4 10 415 5 6292
    regulation of nitrogen compound metabolic process 2.3544E-4 10 416 5 6292
    regulation of gene expression 3.2368E-4 10 445 5 6292
    regulation of macromolecule biosynthetic process 3.6311E-4 10 456 5 6292
    regulation of cellular biosynthetic process 4.2695E-4 10 472 5 6292
    regulation of biosynthetic process 4.3121E-4 10 473 5 6292
    regulation of macromolecule metabolic process 4.9911E-4 10 488 5 6292
    cellular macromolecule catabolic process 5.283E-4 10 265 4 6292
    transcription, DNA-dependent 5.7495E-4 10 503 5 6292
    RNA biosynthetic process 6.0209E-4 10 508 5 6292
    regulation of primary metabolic process 6.3595E-4 10 514 5 6292
    regulation of cellular metabolic process 7.7276E-4 10 536 5 6292
    macromolecule catabolic process 7.8411E-4 10 294 4 6292
    regulation of metabolic process 8.4907E-4 10 547 5 6292
    transcription 8.856E-4 10 552 5 6292
    RNA processing 2.0543E-3 10 380 4 6292
    response to chemical stimulus 2.0947E-3 10 382 4 6292
    cellular catabolic process 2.8459E-3 10 415 4 6292
    cysteine biosynthetic process 3.1764E-3 10 2 1 6292
    negative regulation of transcription from RNA polymerase II promoter 3.8312E-3 10 60 2 6292
    response to stimulus 3.9288E-3 10 766 5 6292
    protein ubiquitination 4.4831E-3 10 65 2 6292
    regulation of cellular process 4.6602E-3 10 796 5 6292
    regulation of biological process 5.4298E-3 10 824 5 6292
    catabolic process 5.4561E-3 10 496 4 6292
    response to pheromone involved in conjugation with cellular fusion 6.0856E-3 10 76 2 6292
    cysteine metabolic process 6.3436E-3 10 4 1 6292
    protein modification by small protein conjugation 7.7386E-3 10 86 2 6292
    traversing start control point of mitotic cell cycle 9.5019E-3 10 6 1 6292
    response to pheromone 9.7663E-3 10 97 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    3'-5'-exoribonuclease activity 2.8091E-8 10 23 4 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 4.7318E-8 10 26 4 6292
    exoribonuclease activity 4.7318E-8 10 26 4 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.4589E-7 10 34 4 6292
    3'-5' exonuclease activity 1.6459E-7 10 35 4 6292
    exonuclease activity 5.0864E-7 10 46 4 6292
    ribonuclease activity 5.6775E-5 10 149 4 6292
    nuclease activity 1.7555E-4 10 199 4 6292
    hydrolase activity, acting on ester bonds 1.3714E-3 10 341 4 6292
    chaperone inhibitor activity 1.5893E-3 10 1 1 6292
    cystathionine beta-synthase activity 1.5893E-3 10 1 1 6292
    Hsp70 protein binding 3.1764E-3 10 2 1 6292
    Hsp90 protein binding 3.1764E-3 10 2 1 6292
    ubiquitin-protein ligase activity 3.4634E-3 10 57 2 6292
    small conjugating protein ligase activity 4.0861E-3 10 62 2 6292
    chaperone activator activity 4.7611E-3 10 3 1 6292
    heat shock protein binding 4.7611E-3 10 3 1 6292
    acid-amino acid ligase activity 5.3288E-3 10 71 2 6292
    hydrolase activity 8.4227E-3 10 911 5 6292
    ligase activity, forming carbon-nitrogen bonds 9.1919E-3 10 94 2 6292

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