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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Kre31. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • BUD3
  • cellular bud neck contractile ring
  • cellular bud neck
  • axial cellular bud site selection
  • cellular bud site selection
  • cytokinesis
  • molecular_function
  • CCT2
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT3
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CCT6
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CIN8
  • spindle microtubule
  • mitochondrion
  • condensed nuclear chromosome kinetochore
  • kinesin complex
  • mitotic sister chromatid segregation
  • mitotic anaphase B
  • mitotic spindle organization in nucleus
  • microtubule motor activity
  • CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • mitochondrion organization
  • molecular_function
  • HIR1
  • nucleus
  • HIR complex
  • chromosome, centromeric region
  • DNA replication-independent nucleosome assembly
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription corepressor activity
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • MNP1
  • mitochondrion
  • mitochondrial ribosome
  • aerobic respiration
  • translation
  • structural constituent of ribosome
  • NAN1
  • RENT complex
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • NOP56
  • box C/D snoRNP complex
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • POL5
  • nucleolus
  • DNA replication
  • rRNA transcription
  • DNA-directed DNA polymerase activity
  • RRP12
  • nucleus
  • ribosome
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • SSD1
  • cytoplasm
  • response to drug
  • cellular cell wall organization
  • replicative cell aging
  • RNA binding
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TMA19
  • cytoplasm
  • mitochondrion
  • cytosol
  • ribosome
  • response to oxidative stress
  • translation
  • molecular_function
  • UTP10
  • mitochondrion
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • UTP7
  • nuclear outer membrane
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    non-membrane-bounded organelle 6.8157E-12 22 959 18 6292
    intracellular non-membrane-bounded organelle 6.8157E-12 22 959 18 6292
    macromolecular complex 6.9066E-7 22 1635 17 6292
    small nucleolar ribonucleoprotein complex 3.8594E-6 22 72 5 6292
    chaperonin-containing T-complex 7.9996E-6 22 12 3 6292
    ribonucleoprotein complex 2.858E-5 22 514 9 6292
    nucleolus 6.3005E-5 22 211 6 6292
    nuclear part 4.8827E-4 22 1103 11 6292
    cytoskeleton 7.4314E-4 22 216 5 6292
    nuclear outer membrane 3.1469E-3 22 86 3 6292
    nuclear lumen 3.721E-3 22 453 6 6292
    nuclear membrane 4.4223E-3 22 97 3 6292
    intracellular part 4.7906E-3 22 4938 22 6292
    intracellular organelle 5.571E-3 22 4070 20 6292
    organelle 5.5941E-3 22 4071 20 6292
    organelle lumen 5.6362E-3 22 660 7 6292
    intracellular organelle lumen 5.6362E-3 22 660 7 6292
    intracellular 5.6476E-3 22 4975 22 6292
    box C/D snoRNP complex 6.9813E-3 22 2 1 6292
    membrane-enclosed lumen 7.7934E-3 22 700 7 6292
    cytosolic part 8.3687E-3 22 122 3 6292
    chromosomal part 8.4061E-3 22 237 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.0903E-6 22 346 9 6292
    maturation of SSU-rRNA 1.4222E-6 22 59 5 6292
    ribonucleoprotein complex biogenesis 2.0963E-6 22 374 9 6292
    rRNA processing 3.6005E-6 22 128 6 6292
    rRNA metabolic process 5.3485E-6 22 137 6 6292
    cellular component biogenesis 4.6835E-5 22 694 10 6292
    ncRNA processing 6.9989E-5 22 215 6 6292
    gene expression 7.7491E-5 22 1283 13 6292
    cellular macromolecule metabolic process 1.0529E-4 22 2285 17 6292
    macromolecule metabolic process 1.5681E-4 22 2349 17 6292
    ncRNA metabolic process 1.8808E-4 22 257 6 6292
    cellular process 4.2871E-4 22 4426 22 6292
    RNA processing 1.5198E-3 22 380 6 6292
    protein folding 2.382E-3 22 78 3 6292
    primary metabolic process 2.8529E-3 22 2896 17 6292
    RNA metabolic process 3.1393E-3 22 954 9 6292
    cellular metabolic process 5.2302E-3 22 3033 17 6292
    chromatin assembly or disassembly 6.4761E-3 22 35 2 6292
    cytoskeleton organization 7.6873E-3 22 231 4 6292
    metabolic process 8.7346E-3 22 3157 17 6292
    translational initiation 9.2338E-3 22 42 2 6292
    organelle organization 9.7965E-3 22 1127 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    snoRNA binding 3.316E-6 22 31 4 6292
    binding 4.4678E-4 22 1294 12 6292
    unfolded protein binding 1.1711E-3 22 61 3 6292
    nucleic acid binding 1.25E-3 22 666 8 6292
    RNA binding 1.2682E-3 22 367 6 6292
    5S rRNA binding 6.9813E-3 22 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle