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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rad50. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DUN1
  • nucleus
  • DNA damage checkpoint
  • cell cycle checkpoint
  • telomere maintenance
  • protein amino acid phosphorylation
  • protein kinase activity
  • MRE11
  • nucleus
  • mitochondrion
  • Mre11 complex
  • DNA repair
  • meiotic DNA double-strand break processing
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • meiotic DNA double-strand break formation
  • adenylate kinase activity
  • 3'-5' exonuclease activity
  • protein binding
  • telomeric DNA binding
  • endonuclease activity
  • endodeoxyribonuclease activity
  • RAD50
  • nucleus
  • mitochondrion
  • Mre11 complex
  • meiotic DNA double-strand break processing
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • telomere maintenance via recombination
  • double-strand break repair via nonhomologous end joining
  • meiosis
  • meiotic DNA double-strand break formation
  • ATPase activity
  • adenylate kinase activity
  • protein binding
  • telomeric DNA binding
  • double-stranded DNA binding
  • REX2
  • mitochondrion
  • RNA processing
  • 3'-5' exonuclease activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • XRS2
  • nucleus
  • Mre11 complex
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • sporulation resulting in formation of a cellular spore
  • meiotic DNA double-strand break formation
  • DNA binding
  • protein binding
  • telomeric DNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Mre11 complex 1.3495E-9 8 3 3 6292
    protein complex 6.9038E-4 8 1137 6 6292
    macromolecular complex 5.1894E-3 8 1635 6 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    double-strand break repair via break-induced replication 1.1295E-7 8 9 3 6292
    meiotic DNA double-strand break formation 2.2161E-7 8 11 3 6292
    double-strand break repair via homologous recombination 2.0548E-6 8 22 3 6292
    double-strand break repair via nonhomologous end joining 3.0634E-6 8 25 3 6292
    recombinational repair 3.4609E-6 8 26 3 6292
    meiotic DNA double-strand break processing 4.2416E-6 8 3 2 6292
    DNA recombination 6.7673E-6 8 114 4 6292
    non-recombinational repair 7.9274E-6 8 34 3 6292
    DNA catabolic process, exonucleolytic 1.4121E-5 8 5 2 6292
    DNA double-strand break processing 1.4121E-5 8 5 2 6292
    nucleic acid phosphodiester bond hydrolysis 1.9966E-5 8 46 3 6292
    double-strand break repair 3.8233E-5 8 57 3 6292
    homeostatic process 5.3228E-5 8 408 5 6292
    meiosis I 1.0197E-4 8 79 3 6292
    response to DNA damage stimulus 1.1994E-4 8 236 4 6292
    DNA catabolic process 1.4733E-4 8 15 2 6292
    regulation of biological quality 2.2653E-4 8 551 5 6292
    anatomical structure homeostasis 2.5313E-4 8 286 4 6292
    telomere organization 2.5313E-4 8 286 4 6292
    telomere maintenance 2.5313E-4 8 286 4 6292
    cellular response to stress 2.671E-4 8 290 4 6292
    DNA metabolic process 3.015E-4 8 585 5 6292
    cellular response to stimulus 7.4705E-4 8 379 4 6292
    meiosis 8.2273E-4 8 160 3 6292
    M phase of meiotic cell cycle 8.2273E-4 8 160 3 6292
    meiotic cell cycle 8.8426E-4 8 164 3 6292
    DNA repair 1.3988E-3 8 192 3 6292
    response to stress 2.0819E-3 8 497 4 6292
    nucleic acid metabolic process 2.3473E-3 8 1415 6 6292
    cell cycle 2.5551E-3 8 525 4 6292
    chromosome organization 3.1417E-3 8 555 4 6292
    cellular macromolecule catabolic process 3.5334E-3 8 265 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.1016E-3 8 1566 6 6292
    cellular macromolecule metabolic process 4.5244E-3 8 2285 7 6292
    M phase 4.7456E-3 8 294 3 6292
    macromolecule catabolic process 4.7456E-3 8 294 3 6292
    macromolecule metabolic process 5.4192E-3 8 2349 7 6292
    intron homing 7.6075E-3 8 6 1 6292
    cellular nitrogen compound metabolic process 7.9712E-3 8 1770 6 6292
    nitrogen compound metabolic process 8.4927E-3 8 1791 6 6292
    biological regulation 8.8033E-3 8 1213 5 6292
    cell cycle phase 9.4607E-3 8 376 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    telomeric DNA binding 2.953E-7 8 12 3 6292
    adenylate kinase activity 8.4777E-6 8 4 2 6292
    nucleotide kinase activity 2.1167E-5 8 6 2 6292
    sequence-specific DNA binding 2.5718E-5 8 50 3 6292
    phosphotransferase activity, phosphate group as acceptor 7.7367E-5 8 11 2 6292
    nucleobase, nucleoside, nucleotide kinase activity 9.2781E-5 8 12 2 6292
    endodeoxyribonuclease activity 3.2267E-4 8 22 2 6292
    deoxyribonuclease activity 5.646E-4 8 29 2 6292
    3'-5' exonuclease activity 8.2428E-4 8 35 2 6292
    exonuclease activity 1.4238E-3 8 46 2 6292
    nuclease activity 1.5517E-3 8 199 3 6292
    ATPase activity 1.8378E-3 8 211 3 6292
    kinase activity 2.1278E-3 8 222 3 6292
    hydrolase activity 2.4085E-3 8 911 5 6292
    endonuclease activity 2.4935E-3 8 61 2 6292
    DNA binding 3.2017E-3 8 256 3 6292
    nucleoside-triphosphatase activity 6.5162E-3 8 329 3 6292
    hydrolase activity, acting on ester bonds 7.2047E-3 8 341 3 6292
    hydrolase activity, acting on acid anhydrides 7.936E-3 8 353 3 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 7.936E-3 8 353 3 6292
    pyrophosphatase activity 7.936E-3 8 353 3 6292

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