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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Fyv14. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 25 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CBF5
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • rRNA pseudouridine synthesis
  • ribosome biogenesis
  • pseudouridylate synthase activity
  • CBP2
  • mitochondrion
  • Group I intron splicing
  • RNA binding
  • DBP7
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ENP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • KAP95
  • cytoplasm
  • nuclear pore
  • protein import into nucleus
  • nuclear pore complex assembly
  • protein transmembrane transporter activity
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • KRI1
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • KRR1
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • MNP1
  • mitochondrion
  • mitochondrial ribosome
  • aerobic respiration
  • translation
  • structural constituent of ribosome
  • MSS116
  • mitochondrial matrix
  • mitochondrion
  • RNA splicing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP58
  • box C/D snoRNP complex
  • nuclear outer membrane
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • NOP6
  • nucleolus
  • rRNA processing
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • PWP1
  • nucleus
  • cytoplasm
  • nucleolus
  • rRNA processing
  • molecular_function
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • TSR1
  • cytoplasm
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • ribonucleoprotein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 5.4626E-22 25 211 18 6292
    nuclear lumen 5.8734E-16 25 453 18 6292
    organelle lumen 6.3877E-16 25 660 20 6292
    intracellular organelle lumen 6.3877E-16 25 660 20 6292
    non-membrane-bounded organelle 1.2532E-15 25 959 22 6292
    intracellular non-membrane-bounded organelle 1.2532E-15 25 959 22 6292
    membrane-enclosed lumen 2.0373E-15 25 700 20 6292
    nuclear part 1.4095E-11 25 1103 20 6292
    intracellular organelle part 1.2386E-7 25 2282 22 6292
    organelle part 1.2386E-7 25 2282 22 6292
    nuclear outer membrane 7.8644E-7 25 86 6 6292
    nucleus 1.3328E-6 25 2041 20 6292
    nuclear membrane 1.6061E-6 25 97 6 6292
    nuclear envelope 8.4372E-6 25 199 7 6292
    intracellular organelle 1.8147E-5 25 4070 25 6292
    organelle 1.8259E-5 25 4071 25 6292
    membrane-bounded organelle 4.7722E-5 25 3771 24 6292
    intracellular membrane-bounded organelle 4.7722E-5 25 3771 24 6292
    outer membrane 5.3321E-5 25 178 6 6292
    organelle outer membrane 5.3321E-5 25 178 6 6292
    eukaryotic translation initiation factor 4F complex 9.0505E-5 25 4 2 6292
    nuclear membrane-endoplasmic reticulum network 2.3129E-4 25 232 6 6292
    endomembrane system 6.8163E-4 25 398 7 6292
    intracellular part 2.3087E-3 25 4938 25 6292
    envelope 2.7581E-3 25 505 7 6292
    organelle envelope 2.7581E-3 25 505 7 6292
    small nucleolar ribonucleoprotein complex 2.7585E-3 25 72 3 6292
    intracellular 2.7836E-3 25 4975 25 6292
    plasma membrane enriched fraction 3.9733E-3 25 1 1 6292
    box C/D snoRNP complex 7.9314E-3 25 2 1 6292
    box H/ACA snoRNP complex 7.9314E-3 25 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 9.4313E-20 25 346 19 6292
    ribonucleoprotein complex biogenesis 4.1849E-19 25 374 19 6292
    cellular component biogenesis 1.7197E-15 25 694 20 6292
    rRNA processing 5.6085E-13 25 128 11 6292
    rRNA metabolic process 1.1975E-12 25 137 11 6292
    ncRNA processing 1.6842E-10 25 215 11 6292
    RNA processing 3.1164E-10 25 380 13 6292
    ncRNA metabolic process 1.1458E-9 25 257 11 6292
    gene expression 3.3494E-7 25 1283 17 6292
    RNA metabolic process 2.6771E-6 25 954 14 6292
    ribosomal large subunit biogenesis 4.5599E-6 25 65 5 6292
    nucleic acid metabolic process 5.6893E-5 25 1415 15 6292
    cellular process 1.4853E-4 25 4426 25 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.9715E-4 25 1566 15 6292
    cellular macromolecule metabolic process 3.0053E-4 25 2285 18 6292
    macromolecule metabolic process 4.4697E-4 25 2349 18 6292
    ribosomal large subunit assembly 5.3476E-4 25 41 3 6292
    cellular nitrogen compound metabolic process 8.3774E-4 25 1770 15 6292
    nitrogen compound metabolic process 9.5963E-4 25 1791 15 6292
    ribosomal subunit assembly 1.2687E-3 25 55 3 6292
    processing of 27S pre-rRNA 1.7579E-3 25 16 2 6292
    ribosome assembly 1.9679E-3 25 64 3 6292
    rRNA modification 2.2305E-3 25 18 2 6292
    organelle assembly 2.4425E-3 25 69 3 6292
    pore complex assembly 3.9733E-3 25 1 1 6292
    nuclear pore complex assembly 3.9733E-3 25 1 1 6292
    cellular macromolecular complex assembly 5.3229E-3 25 182 4 6292
    ribonucleoprotein complex assembly 5.5124E-3 25 92 3 6292
    primary metabolic process 7.6905E-3 25 2896 18 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 3.723E-6 25 28 4 6292
    RNA-dependent ATPase activity 4.3071E-6 25 29 4 6292
    RNA helicase activity 1.9604E-5 25 42 4 6292
    ATP-dependent helicase activity 3.3536E-5 25 48 4 6292
    purine NTP-dependent helicase activity 3.3536E-5 25 48 4 6292
    helicase activity 2.8838E-4 25 83 4 6292
    ribonucleoprotein binding 3.1446E-4 25 7 2 6292
    ATPase activity, coupled 2.593E-3 25 149 4 6292
    ribosomal large subunit binding 3.9733E-3 25 1 1 6292
    7S RNA binding 3.9733E-3 25 1 1 6292
    translation initiation factor activity 5.0062E-3 25 27 2 6292
    5S rRNA binding 7.9314E-3 25 2 1 6292
    nucleoside-triphosphatase activity 8.4735E-3 25 329 5 6292
    ATPase activity 8.9376E-3 25 211 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle