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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 18 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CSL4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • response to exogenous dsRNA
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    DDI1
  • plasma membrane
    		•
  • vesicle-mediated transport
  • ubiquitin-dependent protein catabolic process
    		•
  • SNARE binding
    		•
    DIS3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • mitochondrion
  • nuclear outer membrane
    		•
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    ENT3
  • clathrin vesicle coat
  • actin cortical patch
    		•
  • protein targeting
  • actin filament organization
  • endocytosis
  • actin cortical patch assembly
  • Golgi to endosome transport
    		•
  • protein binding
    		•
    LRP1
  • nuclear exosome (RNase complex)
    		•
  • DNA repair
  • snRNA processing
  • double-strand break repair via homologous recombination
  • telomere maintenance
  • snoRNA processing
  • double-strand break repair via nonhomologous end joining
  • mRNA catabolic process
  • processing of 27S pre-rRNA
    		•
  • molecular_function
    		•
    MPP6
  • nucleus
  • ribosome
    		•
  • biological_process
    		•
  • molecular_function
    		•
    MTR3
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    OSM1
  • mitochondrion
    		•
  • metabolic process
    		•
  • fumarate reductase (NADH) activity
    		•
    RRP4
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
  • RNA binding
    		•
    RRP40
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • ribosome assembly
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
  • RNA binding
    		•
    RRP42
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP43
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP45
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP46
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    RRP6
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • ribosome biogenesis
  • mRNA catabolic process
  • polyadenylation-dependent ncRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    SKI6
  • cytoplasmic exosome (RNase complex)
  • nuclear exosome (RNase complex)
  • nuclear outer membrane
    		•
  • response to exogenous dsRNA
  • mRNA catabolic process
    		•
  • 3'-5'-exoribonuclease activity
    		•
    SKI7
  • cytoplasm
  • exosome (RNase complex)
    		•
  • response to exogenous dsRNA
  • mRNA catabolic process
    		•
  • protein binding
    		•
    YBL055C
  • cytoplasm
    		•
  • response to oxidative stress
  • DNA fragmentation involved in apoptosis
    		•
  • endonuclease activity
  • 3'-5'-exodeoxyribonuclease activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    exosome (RNase complex) 1.246E-33 18 16 13 6292
    nuclear exosome (RNase complex) 1.0592E-30 18 15 12 6292
    cytoplasmic exosome (RNase complex) 1.0829E-25 18 12 10 6292
    nuclear outer membrane 4.7435E-17 18 86 11 6292
    nuclear membrane 1.9068E-16 18 97 11 6292
    outer membrane 1.8305E-13 18 178 11 6292
    organelle outer membrane 1.8305E-13 18 178 11 6292
    nuclear envelope 6.3168E-13 18 199 11 6292
    nuclear membrane-endoplasmic reticulum network 3.436E-12 18 232 11 6292
    endomembrane system 4.5869E-11 18 398 12 6292
    envelope 1.518E-8 18 505 11 6292
    organelle envelope 1.518E-8 18 505 11 6292
    membrane part 1.7107E-8 18 662 12 6292
    organelle membrane 2.8403E-8 18 692 12 6292
    protein complex 5.4675E-8 18 1137 14 6292
    macromolecular complex 5.6423E-7 18 1635 15 6292
    membrane 1.3431E-6 18 1198 13 6292
    nuclear part 5.2291E-6 18 1103 12 6292
    nucleus 6.2391E-4 18 2041 13 6292
    intracellular organelle part 2.0665E-3 18 2282 13 6292
    organelle part 2.0665E-3 18 2282 13 6292
    cytoplasmic part 4.9394E-3 18 2482 13 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mRNA catabolic process 8.2678E-23 18 69 13 6292
    RNA catabolic process 6.686E-22 18 80 13 6292
    cellular macromolecule catabolic process 1.1506E-18 18 265 15 6292
    macromolecule catabolic process 5.6124E-18 18 294 15 6292
    mRNA metabolic process 3.9401E-16 18 213 13 6292
    cellular catabolic process 1.0385E-15 18 415 15 6292
    catabolic process 1.5114E-14 18 496 15 6292
    RNA metabolic process 8.4641E-8 18 954 13 6292
    response to exogenous dsRNA 6.8335E-7 18 7 3 6292
    response to dsRNA 6.8335E-7 18 7 3 6292
    nucleic acid metabolic process 9.6947E-7 18 1415 14 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.5975E-6 18 1566 14 6292
    cellular nitrogen compound metabolic process 1.7139E-5 18 1770 14 6292
    nitrogen compound metabolic process 1.9891E-5 18 1791 14 6292
    cellular macromolecule metabolic process 5.7838E-5 18 2285 15 6292
    macromolecule metabolic process 8.3917E-5 18 2349 15 6292
    polyadenylation-dependent RNA catabolic process 2.1426E-4 18 8 2 6292
    polyadenylation-dependent ncRNA catabolic process 2.1426E-4 18 8 2 6292
    metabolic process 6.7953E-4 18 3157 16 6292
    primary metabolic process 1.3126E-3 18 2896 15 6292
    cellular metabolic process 2.3595E-3 18 3033 15 6292
    apoptotic nuclear change 2.8608E-3 18 1 1 6292
    DNA fragmentation involved in apoptosis 2.8608E-3 18 1 1 6292
    cellular component disassembly involved in apoptosis 2.8608E-3 18 1 1 6292
    response to organic substance 6.4849E-3 18 137 3 6292
    snRNA processing 8.5592E-3 18 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.2552E-24 18 34 12 6292
    3'-5' exonuclease activity 1.9084E-24 18 35 12 6292
    3'-5'-exoribonuclease activity 2.7971E-24 18 23 11 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 1.5934E-23 18 26 11 6292
    exoribonuclease activity 1.5934E-23 18 26 11 6292
    exonuclease activity 8.8127E-23 18 46 12 6292
    nuclease activity 1.1337E-14 18 199 12 6292
    ribonuclease activity 2.5053E-14 18 149 11 6292
    hydrolase activity, acting on ester bonds 7.3568E-12 18 341 12 6292
    hydrolase activity 6.3367E-7 18 911 12 6292
    catalytic activity 1.096E-3 18 2150 13 6292
    fumarate reductase (NADH) activity 5.7138E-3 18 2 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle