YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	24 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ALG3	endoplasmic reticulum	protein amino acid glycosylation dolichol-linked oligosaccharide biosynthetic process	alpha-1,3-mannosyltransferase activity
BUD27	cytoplasm	cellular bud site selection	molecular_function
CBF2	spindle midzone CBF3 complex spindle condensed nuclear chromosome kinetochore	mitotic spindle elongation chromosome segregation	DNA bending activity centromeric DNA binding
DST1	nucleoplasm	reciprocal meiotic recombination RNA elongation from RNA polymerase II promoter mRNA cleavage	positive transcription elongation factor activity
ESS1	nucleus	negative regulation of transcription from RNA polymerase II promoter mRNA processing termination of RNA polymerase II transcription negative regulation of phosphorylation	transcription elongation regulator activity peptidyl-prolyl cis-trans isomerase activity
IWR1	nucleus cytoplasm DNA-directed RNA polymerase II, holoenzyme	transcription from RNA polymerase II promoter meiosis	molecular_function
RPB10	DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase III promoter transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPB11	DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPB2	mitochondrion DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPB3	DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPB4	nucleus cytoplasm cytoplasmic mRNA processing body DNA-directed RNA polymerase II, core complex	mRNA export from nucleus telomere maintenance transcription from RNA polymerase II promoter nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	DNA-directed RNA polymerase activity
RPB5	DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase III promoter transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPB7	DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPB8	DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase III promoter transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPB9	DNA-directed RNA polymerase II, core complex	response to drug transcription-coupled nucleotide-excision repair telomere maintenance transcription from RNA polymerase II promoter response to DNA damage stimulus	DNA-directed RNA polymerase activity
RPO21	mitochondrion DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
RPO26	DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase III promoter transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter	DNA-directed RNA polymerase activity
SPT4	nucleus transcription elongation factor complex DSIF complex kinetochore nuclear chromosome, telomeric region	regulation of transcription, DNA-dependent chromosome segregation chromatin silencing chromatin organization RNA elongation from RNA polymerase II promoter	RNA polymerase II transcription elongation factor activity
TAF14	SWI/SNF complex transcription factor TFIID complex Ino80 complex transcription factor TFIIF complex histone acetyltransferase complex	chromatin remodeling regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TFG1	transcription factor TFIIF complex	transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TFG2	transcription factor TFIIF complex	transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
YBL059W	mitochondrion	biological_process	molecular_function
YBR259W	cellular_component	biological_process	molecular_function
YPL225W	cytoplasm ribosome	biological_process	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
DNA-directed RNA polymerase II, core complex	1.9675E-27	24	12	11	6292
DNA-directed RNA polymerase II, holoenzyme	2.7879E-26	24	56	15	6292
DNA-directed RNA polymerase complex	1.339E-20	24	31	11	6292
RNA polymerase complex	1.339E-20	24	31	11	6292
nuclear DNA-directed RNA polymerase complex	1.339E-20	24	31	11	6292
nucleoplasm	6.205E-19	24	264	17	6292
nucleoplasm part	9.5967E-18	24	245	16	6292
nuclear lumen	6.0893E-15	24	453	17	6292
organelle lumen	3.1764E-12	24	660	17	6292
intracellular organelle lumen	3.1764E-12	24	660	17	6292
membrane-enclosed lumen	8.3419E-12	24	700	17	6292
nuclear part	1.0034E-9	24	1103	18	6292
protein complex	2.0166E-8	24	1137	17	6292
transcription factor TFIIF complex	4.8776E-8	24	3	3	6292
DNA-directed RNA polymerase I complex	1.5893E-7	24	14	4	6292
DNA-directed RNA polymerase III complex	3.75E-7	24	17	4	6292
macromolecular complex	6.8573E-7	24	1635	18	6292
nucleus	3.3252E-6	24	2041	19	6292
nucleolar part	2.1859E-5	24	45	4	6292
intracellular organelle part	1.2488E-4	24	2282	18	6292
organelle part	1.2488E-4	24	2282	18	6292
transcription factor complex	2.3513E-3	24	71	3	6292
intracellular organelle	2.7359E-3	24	4070	22	6292
organelle	2.7486E-3	24	4071	22	6292
membrane-bounded organelle	3.3895E-3	24	3771	21	6292
intracellular membrane-bounded organelle	3.3895E-3	24	3771	21	6292
DSIF complex	7.6148E-3	24	2	1	6292
nucleolus	7.7063E-3	24	211	4	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
transcription from RNA polymerase II promoter	7.6296E-19	24	335	18	6292
transcription, DNA-dependent	1.1424E-15	24	503	18	6292
RNA biosynthetic process	1.3626E-15	24	508	18	6292
transcription	5.9652E-15	24	552	18	6292
RNA metabolic process	8.4426E-11	24	954	18	6292
cellular macromolecule biosynthetic process	2.4695E-10	24	1187	19	6292
macromolecule biosynthetic process	2.5457E-10	24	1189	19	6292
gene expression	1.2762E-8	24	1283	18	6292
cellular biosynthetic process	3.4894E-8	24	1567	19	6292
biosynthetic process	5.141E-8	24	1602	19	6292
nucleic acid metabolic process	6.4802E-8	24	1415	18	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.41E-7	24	1566	18	6292
cellular nitrogen compound metabolic process	2.4472E-6	24	1770	18	6292
nitrogen compound metabolic process	2.9521E-6	24	1791	18	6292
transcription from RNA polymerase I promoter	4.1773E-6	24	30	4	6292
transcription from RNA polymerase III promoter	1.1024E-5	24	38	4	6292
cellular macromolecule metabolic process	2.1855E-5	24	2285	19	6292
macromolecule metabolic process	3.4384E-5	24	2349	19	6292
transcription initiation from RNA polymerase II promoter	7.0835E-4	24	47	3	6292
primary metabolic process	9.4559E-4	24	2896	19	6292
transcription initiation	1.3113E-3	24	58	3	6292
cellular metabolic process	1.8975E-3	24	3033	19	6292
metabolic process	3.426E-3	24	3157	19	6292
transcription-coupled nucleotide-excision repair	7.6148E-3	24	2	1	6292
RNA elongation from RNA polymerase II promoter	9.481E-3	24	39	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA polymerase activity	4.4985E-20	24	34	11	6292
DNA-directed RNA polymerase activity	4.4985E-20	24	34	11	6292
nucleotidyltransferase activity	6.557E-12	24	168	11	6292
transferase activity, transferring phosphorus-containing groups	1.1641E-7	24	420	11	6292
transferase activity	9.9098E-6	24	797	12	6292
transcription elongation regulator activity	4.5405E-5	24	19	3	6292
transcription regulator activity	1.3766E-3	24	339	6	6292
general RNA polymerase II transcription factor activity	1.7443E-3	24	64	3	6292
positive transcription elongation factor activity	3.8144E-3	24	1	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis