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Protein Overview: FUN19

General Information:
Name(s) found: FUN19 / YAL034C [SGD]
Description(s) found:
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  • gi|97537625|sp|P28003.3|YAD4_YEAST RecName: Full=SWIRM domain-containing protein FUN19 [NCBI NR]
  • gi|37362610|ref|NP_009368.2| Non-essential protein of unknown function; Fun19p [Saccharomyces cerevisiae] [NCBI NR]
  • SWIRM domain-containing protein FUN19 OS=Saccharomyces cerevisiae GN=YAL034C PE=1 SV=3 [Swiss-Prot]
  • SWIRM domain-containing protein FUN19 OS=Saccharomyces cerevisiae GN=FUN19 PE=1 SV=3 [Swiss-Prot]
  • FUN19 Protein of unknown function [mips]
  • Non-essential protein of unknown function; expression induced in response to heat stress [SGD]
  • Chr I from 81953-80712, reverse complement [yeastorf5.fasta]
  • FUN19 SGDID:S0002134, Chr I from 81954-80713, reverse complement, Verified ORF [yeastflysequest.fasta]
  • FUN19 SGDID:S0002134, Chr I from 81952-80711, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Fun19p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • FUN19 SGDID:S000002134, Chr I from 81952-80711, reverse complement, Verified ORF, "Non-essential protein of unknown function" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • FUN19 SGDID:S000002134, Chr I from 81952-80711, reverse complement, Verified ORF, "Non-essential protein of unknown function; expression induced in response to heat stress" [yeast-200209-contam.fasta]
  • Uncharacterized protein FUN19 [nr-271106-contam.fasta]
  • Non-essential protein of unknown function; Fun19p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • SWIRM domain-containing protein FUN19 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUN19 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • FUN19 SGDID:S000002134, Chr I from 81951-80710, Genome Release 64-1-1, reverse complement, Verified ORF, "Non-essential protein of unknown function; expression induced in response to heat stress" [yeast-030211-contam.fasta]
  • FUN19 SGDID:S000002134, Chr I from 81951-80710, Genome Release 64-2-1, reverse complement, Verified ORF, "Non-essential protein of unknown function; expression induced in response to heat stress; FUN19 has a paralog, YOR338W, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YAL034C SGDID:S000002134, Chr I from 81951-80710, Genome Release 64-1-1, reverse complement, Verified ORF, "Non-essential protein of unknown function; expression induced in response to heat stress" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 413 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM SDYSNNSPYG  60
   61 RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK LESKISHNGS PRMASSVLVG 120
  121 STPKGAVENV LFVKPVWPNG LSRKRYRYAT YGFLSQYKIF SNLAQPYSKN IINRYNNLAY 180
  181 NARHKYSKYN DDMTPPPLPS SSSRLPSPLA SPNLNRQARY NMRKQALYNN NLGKFESDTE 240
  241 WIPRKRKVYS PQRRTMTTSP HRAKKFSPSA STPHTNIASI EAIHDAPQYI PNVSWKKLPD 300
  301 YSPPLSTLPT DSNKSLKIEW KGSPMDLSTD PLRNELHPAE LVLAQTLRLP CDLYLDSKRR 360
  361 LFLEKVYRLK KGLPFRRTDA QKACRIDVNK ASRLFQAFEK VGWLQDSNFT KYL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FUN19 SAP30 SIN3
    View Details Krogan NJ, et al. (2006) FUN19 KAP123 YMR290W-A YNL122C
    View Details Gavin AC, et al. (2006) FUN19 KAP123 RPS1B RPS5 YPR174C
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 VAS1 VPS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen FUN19 YKL061W 2 Unpublished Fields Lab Data
    View Screen FUN19 DAD1 2 Unpublished Fields Lab Data
    View Screen FUN19 RNP1 2 Unpublished Fields Lab Data
    View Screen FUN19 IES3 2 Unpublished Fields Lab Data
    View Screen FUN19 SRB7 2 Unpublished Fields Lab Data
    View Screen FUN19 NKP1 2 Unpublished Fields Lab Data
    View Screen FUN19 HAC1 2 Unpublished Fields Lab Data
    View Screen FUN19 VPS45 2 Unpublished Fields Lab Data
    View Screen FUN19 MED11 2 Unpublished Fields Lab Data
    View Screen FUN19 SIP2 2 Unpublished Fields Lab Data
    View Screen FUN19 PET494 2 Unpublished Fields Lab Data
    View Screen FUN19 KAR3 2 Unpublished Fields Lab Data
    View Screen FUN19 YBR284W 1 Unpublished Fields Lab Data
    View Screen ROM1 FUN19 1 Unpublished Fields Lab Data
    View Screen FUN19 APM3 1 Unpublished Fields Lab Data
    View Screen FUN19 YNK1 1 Unpublished Fields Lab Data
    View Screen YHR122W FUN19 1 Hazbun TR, et al. (2003)
    View Screen FUN19 OAF3 1 Unpublished Fields Lab Data
    View Screen GYP6 FUN19 1 Unpublished Fields Lab Data
    View Screen FUN19 PDS1 1 Unpublished Fields Lab Data
    View Screen LSM8 FUN19 1 Unpublished Fields Lab Data
    View Screen FUN19 NGG1 1 Unpublished Fields Lab Data
    View Screen PRR1 FUN19 1 Unpublished Fields Lab Data
    View Screen FUN19 BUD20 1 Unpublished Fields Lab Data
    View Screen RAD1 FUN19 1 Unpublished Fields Lab Data
    View Screen FUN19 MAS1 1 Unpublished Fields Lab Data
    View Screen FUN19 PPZ2 1 Unpublished Fields Lab Data
    View Screen FUN19 POB3 1 Unpublished Fields Lab Data
    View Screen FUN19 SPG4 1 Unpublished Fields Lab Data
    View Screen FUN19 YMR304C-A 1 Unpublished Fields Lab Data
    View Screen FUN19 VID30 1 Unpublished Fields Lab Data
    View Screen FUN19 URE2 1 Unpublished Fields Lab Data
    View Screen FUN19 ROM1 1 Unpublished Fields Lab Data
    View Screen FUN19 KIN3 1 Unpublished Fields Lab Data
    View Screen FUN19 BTN2 1 Unpublished Fields Lab Data
    View Screen FUN19 MED1 1 Unpublished Fields Lab Data
    View Screen FUN19 ROX3 1 Unpublished Fields Lab Data
    View Screen FUN19 UBA4 1 Unpublished Fields Lab Data
    View Screen FUN19 YPR089W 1 Unpublished Fields Lab Data
    View Screen FUN19 AKL1 1 Unpublished Fields Lab Data
    View Screen FUN19 PAN1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209] MSA 1.070993 View MSA. No confident structure predictions are available.
    2 View Details [210..312] MSA 3.080997 View MSA. No confident structure predictions are available.
    3 View Details [313..413] PSI-BLAST 23.69897 Structural and functional analysis of ada2 alpha swirm domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.61657063316558 bayes_pls_golite062009
  • DNA binding
    		•  3.20600447901865 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.13775670276163 bayes_pls_golite062009
  • transcription factor activity
    		•  2.61318050866004 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.14408928200987 bayes_pls_golite062009
  • binding
    		•  2.12643314274039 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.77209608685482 bayes_pls_golite062009
  • transcription activator activity
    		•  1.75864690109096 bayes_pls_golite062009
  • protein binding
    		•  1.62529996900514 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.605733396003465 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.380372494934551 bayes_pls_golite062009
  • chromatin binding
    		•  0.346262410069781 bayes_pls_golite062009
  • transcription factor binding
    		•  0.109547968922689 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle